A directory of core research facilities, services, and instrumentation in Rhode Island

Core Facilities Categories

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Behavioral Phenotyping

VA Providence Healthcare System
FacilityInstrument/Service/Resource Unit
IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Behavioral Phenotyping - Hypoxia Chamber

BioSpherix Rodent Hypoxia Chamber
The A-Chamber works with a large range of BioSpherix Ltd. gas controllers. These controllers continuously monitor atmospheric condition, ensuring humane conditions as well as experimental integrity for Hypoxia studies.

Biomechanics

Brown University
FacilityInstrument/Service/Resource Unit
X-ray Reconstruction of Moving Morphology Facility (XROMM)

Contact: Beth Brainerd, PhD

Imaging System - Computed Tomography (CT) Scanner

Animage Fidex Veterinary
Veterinary CT Scanner designed for animals in the size range from rats to dogs. In vivo scanning of anesthetized animals is possible.

X-ray Reconstruction of Moving Morphology Facility (XROMM)

Contact: Beth Brainerd, PhD

Imaging System - Videoradiography Room

Imaging Systems and Services
Custom designed biplanar videoradiography system for XROMM studies of human and animal subjects.

X-ray Reconstruction of Moving Morphology Facility (XROMM)

Contact: Beth Brainerd, PhD

Imaging system X-Ray Fluoroscopes

Radiological Imaging Mobile C-Arm X-ray
Two retrofitted with 30-cm image intensifiers and high-speed video cameras for measuring accurate 3D skeletal kinematics of small to medium-sized animals.

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Bioengineering Core

Contact: Braden Fleming, PhD

Analysis System - Gait

Noldus
Catwlak small animal system

Bioengineering Core

Contact: Braden Fleming, PhD

Analysis System - Force Plate

Kistler
5 KN portable (6 channel)

Bioengineering Core

Contact: Braden Fleming, PhD

Electromyography (EMG) monitor

Noraxon
Wireless EMG system (8 channel)

Bioengineering Core

Contact: Braden Fleming, PhD

Analysis System - Force Plate

Tekscan Force Plate Walkway
Low profile floor walkway system that captures multiple sequential foot strikes of animals.

Bioengineering Core

Contact: Braden Fleming, PhD

Analysis System - Gait

Tekscan High Resolution Walkway (HRV6)
Modular pressure measurement platform for gait analysis.

Bioengineering Core

Contact: Braden Fleming, PhD

Analyzer - Motion

Northern Digital Optotrak System
Track and analyze kinetics and dynamic motion in real-time

Bioengineering Core

Contact: Braden Fleming, PhD

Analyzer - Pressure

Tekscan I-scan
Pressure Mapping System

Bioengineering Core

Contact: Braden Fleming, PhD

Loading Device

Custom Biaxial Loading Device
Tissue Engineering

Bioengineering Core

Contact: Braden Fleming, PhD

Analysis System - Mapping System

Fuji Film Prescale Pressuregraph (FPD-901E)
Pressure Distribution Mapping System

Bioengineering Core

Contact: Braden Fleming, PhD

Pendulum

Custom Active pendulum (small animal joint)
System to induce frictional wear in arthrodial joints

Bioengineering Core

Contact: Braden Fleming, PhD

Pendulum

Custom Passive pendulums (small and large animal joints)
System to measure the whole joint coefficient of friction

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Equipment

KUKA KR6 700 SIXX
6 DOF joint motion testing

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

Bose Corp Biaxial ELF 3200 material test system
Force Testers (Tension, Compression, Pull Testers). The ELF 3200 Series perform basic materials tests including axial, axial/torsion, fretting, biaxial, and planar biaxial fatigue tests.

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

Instron 8521S
Axial-Torsional Fatigue Testing System

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

Instron Electropuls E1000
All-Electric Dynamic Test Instrument designed for dynamic and static testing on a wide range of materials and components.

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

Instron E10000LT
Biaxial material test system

Bioengineering Core

Contact: Braden Fleming, PhD

Testing Systems

MTS Bionix Electromechanical Torsion System
Torsion Test System

Bioengineering Core

Contact: Braden Fleming, PhD

Tissue Engineering System

ICCT Technologies Bio-Stretch Uniaxial System
Mechanical Stretching for Tissue Engineering

Botany

Brown University
FacilityInstrument/Service/Resource Unit
Plant Environmental Center

Contact: Nicholas Vasques

Greenhouse

Plant environmental center with seven separate, computer controlled rooms where conditions like lighting, temperature, and humidity can be fine tuned; an additional 17 controlled plant growth environments provided by growth chambers (15) and walk-in growth rooms (2)
A plant environmental center with a suite of supporting facilities, including a classroom, a headhouse for potting and other prep work, and growth chambers for plants.

Brown University Herbarium

Contact: Rebecca Kartzinel

Herbarium

Dried and pressed plant specimens mounted on sheets of archival paper. Plant data.
The collection includes around 100,000 plant specimens and is an important depository of Rhode Island and New England collections. It is also rich in western and southern North American plants and includes special sets of historically valuable specimens from 19th and early 20th century western US expeditions. Among other important collections, the herbarium also includes a full set of Charles Wright's Cuban plants (1856-1867) and a unique and classic collection of Carex

Providence College
FacilityInstrument/Service/Resource Unit
PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Environmental Chamber

Percival Scientific
1 unit

PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Environmental Chamber

Percival Scientific, AR-22L Growth Chamber
For Arabidopsis

Chemistry

Brown University
FacilityInstrument/Service/Resource Unit
Environmental Chemistry Facility

Contact: Marcelo Alexandre

Mass Spectrometer - Isotope Ratio Mass Spectrometer

Thermo Scientific GC-C-IRMS Delta V Plus
Used primarily for compound specific ð13C in organic extracts

Mass Spectrometry Facility (Brown Chemistry)

Contact: Lisa Chen

High Performance Liquid Chromatography (HPLC) - Analytical and preparative HPLC

Agilent 1260 Infinity LC
The 1260 HPLC is used primarily for analytical and semi-prep scale HPLC separation and purification of components in chemical mixtures.  This system consisted a quaternary pump, autosampler, thermostatted column compartment, diode array detector (190 – 950 nm), and fraction collector.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Accelerated Solvent Extractor (ASE)

ASE 200 Dionex
Used to extract organic compounds from solid samples.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Liquid Chromatography - Mass Spectrometer

Agilent 1200 LC/MS System
Used to separate and then quantify the chemical components in a given sample.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Gas Chromatography - Flame Ionization Detector

Agilent 7090B GC-FID
Used to measure the trace levels of semivolatile organic compounds in a given organic extracted sample.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Gas Chromatography - Mass Spectrometer

Agilent 5977B GC-MSD
Used to determine molecular composition and the concentration of organic compounds in organic extracted samples

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Mass Spectrometer - Isotope Ratio Mass Spectrometer

Thermo Scientific GC/EA-C-IRMS Delta V Plus
GC: Used primarily for compound specific ð D in organic extracts; EA: Used for bulk organic ð13C and ð15N in solid samples.

Bryant University
FacilityInstrument/Service/Resource Unit
Bryant Unistructure Science Spaces

Contact: Christopher Reid

Chromatography - Flash

Interchim-Advion
Separation of organic molecules

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Mass Spectrometer (ESI and APCI) Compact with plate express

Interchim-Advion
Analyze organics, biomolecules

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Sample Preparation - Chromatography - Solvent Extractor

Dionex ASE 350 Accelerated Solvent Extractor (ASE)
Accelerated extractions

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Nuclear Magnetic Resonance (NMR) Benchtop

Nanalysis Benchtop nuclear magnetic resonance (100 MHz)
Analysis of organic molecules

Bryant Unistructure Science Spaces

Contact: Christopher Reid

High Performance Liquid Chromatography (HPLC)

Shumatzu
Analyze for non-volatile organics

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Gas Chromatograph - Mass Spectrometer (GC - MS)

Agilent Technologies 7890A GC and 5975C MSD
Analyze for volatile organics; pyrolysis; MSD and FID

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Worstation - Concentrator

Caliper LifeSciences Turbo Vap LV Concentration Workstation
Concentrator

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Chemical Hood

Thermo Scientific Hamilton SafeAire II
Chemical hood and ultra-high vacuum system for organic synthesis

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Evaporator

Buchi R-124 Rotavapor
Rotary evaporator comes complete with a 45 degree water condenser and a 1L condensing and evaporating flask.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Sample Preparation - Circulator

VWR Recirculating Chiller, Model 1160A
Stable cooling for many common heat removal applications such as rotary evaporators and vacuum systems (-10 to 40C).

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

High Performance Liquid Chromatography (HPLC)

Agilent Technologies, 1260 Infinity HPLC system
A maximum pressure of 600 bar to utilize smaller particle size columns for higher resolution and faster separations.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Sample Preparation - Freeze Dry System

Labconco FreeZone Plus 2.5L Cascade Benchtop Lyophilizer
This system is for light sample loads with low eutectic points. It can remove up to 1.8L of water in 24hrs and holds 2.5L of ice before defrosting is required.

Roger Williams University
FacilityInstrument/Service/Resource Unit
RWU Lab Spaces

Contact: Nancy Breen

Gas Chromatograph - Mass Spectrometer (GC - MS)

Agilent 5890 Gas Chromatograph - Mass Spectrometer (GC - MS) wth Mass Selective Detetor (MSD)
GC MS for teaching and research

RWU Lab Spaces

Contact: Nancy Breen

High Performance Liquid Chromatography (HPLC)

Waters 2695 High Performance Liquid Chromatograph-MS / ZQ Micromass Mass Spectrometer
LC - MS for teaching and research

RWU Lab Spaces

Contact: Nancy Breen

Gas Chromatograph

Agilent 7890 Gas Chromatography with DB-23 column
GC for fatty acid analysis

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
URI Sources, Transport, Exposure & Effects of PFAS (STEEP)

Contact: Simon Vojta

Mass Spectrometer

SCIEX X500R QTOF PLATFORM coupled to an EXION LC AC SYSTEM
A tandem (MS/MS) mass spectrometer combining a quadrupole and a time-of-flight analyzer allows collecting high-resolution MS and MRM spectra. The instrument is suitable for both quantitative analysis as well as non-targeted approach and operates under SCIEX OS software. The collected data are evaluated using an independent processing station (SCIEX Alpha Workstation 2020) equipped with SCIEX OS-Q software

Clinical Translational Research Resources

Brown University
FacilityInstrument/Service/Resource Unit
Advance-CTR

Contact: Heather Fournier

Research - Biostatistical Consulting, Epidemiology & Clinical Research Design Services

Clinical Research Service, Advance-CTR
A team of experienced statisticians and methodological experts are on-hand to help investigators prepare their proposals pre-award, and plan their projects upon receipt of funding. Pre-award services include, positioning of specific aims and hypotheses, measure selection, power analysis and data analysis planning. Post-award services include decision support services, data acquisition and management and consultations to assess the impact of potential design changes on final statistical influence. Data analysis and results interpretation services include implementing data analysis plans, statistical analysis consultations, selecting and accessing statistical analysis software, and coaching to best utilize statistical analysis software. Manuscript and grant proposal writing services include assistance with write-ups, data visualizations, integration of interpretations in the broader context of the project, and addressing comments from peer reviewers.

Advance-CTR

Contact: Heather Fournier

Research - Biomedical Informatics Services

Clinical Research Service, Advance-CTR
Researchers may request, access, and use data available through the Unified Research data Sharing Access (URSA) infrastructure. The data include information originating from electronic health data systems at Lifespan, Care New England, and the Rhode Island Quality Institute, as well as from publicly accessible biological and health data sets.

IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE)

Contact: Jennifer Tidey, Ph.D.

Clinical Laboratory Core

Service
The CADRE Clinical Laboratory Core (CLC) is a 'one-stop shopping' resource for clinical laboratory investigators. We provide laboratory space, supplies, equipment, research nursing capability, biomarker processing capability, scientific expertise and data management/analysis expertise. Provision of these resources via the CLC improves efficiency, consistency and economy of scale across projects.

Advance-CTR

Contact: Heather Fournier

Research - Community Engagement & Outreach Core

Clinical Research Service, Advance-CTR
The CEO Core helps facilitate research endeavors that are relevant, accessible, and impactful to the entire state of Rhode Island.

Advance-CTR

Contact: Heather Fournier

Administration Advance-CTR

Clinical Research Service, Advance-CTR Service Coordination
Advance-CTR works to support researchers at the state level by developing the infrastructure and resources investigators need to conduct clinical and translational research in Rhode Island. Through its interdisciplinary and inter-institutional model, Advance-CTR funds and supports research across the translational science spectrum, including basic science, clinical, and public health efforts. Ultimately, Advance-CTR seeks to connect researchers and support institutions in Rhode Island in order to advance clinical and translational research that improves public health in the state.

Advance-CTR

Contact: Heather Fournier

Research - Qualitative Methods Services

Clinical Research Service, Advance-CTR
This service provides qualitative and mixed methods and data analysis design research support. Qualitative and mixed methods support includes; study design and preparation, original measure development, coaching on qualitative methods design decisions (focus groups, interviews, cognitive interviews), NVivo qualitative software training, help with grant writing of qualitative methods and analysis sections, manuscript and grant proposal review, post interview/focus group debriefing. Data analysis design support includes applied thematic analysis and framework matrix analysis.

Brown University Oncology Group (BRUOG)

Contact: Howard Safran, MD

Research - Oncology

Clinical Trials Support, Oncology Research
The Brown University Oncology Research Group (BrUOG) mission is to improve cancer care through the implementation of innovative, multidisciplinary cancer clinical trials. BrUOG provides the infrastructure for the efficient development and implementation of these trials, which are created by Brown University faculty. BrUOG’s administrators and physicians provide support for the initial study concept and validation of trial design, and are responsible for trial administration, safety monitoring, data analysis, and the presentation and publication of findings. The trials sponsored by BrUOG investigate novel, cutting-edge applications of chemotherapy, biologic agents and other cancer treatments. Clinical trials are available for a broad range of disorders in hematology/oncology and these include treatment for cancers of the breast, brain, lung, gastrointestinal tract, skin, and prostate as well as trials in leukemia and lymphoma.

Brown-Lifespan Center for Digital Health

Contact: Megan Ranney MD, MPH

Research - Emergency Digital Health Resources

Clinical Research Resources, Emergency Digital Health
EDHI’s mission is to use digital health to transform the care of patients with acute care needs before, during, and after their visit by developing and deploying effective, evidence-based digital health tools. The goal is to use technology to improve access to patients and increase the efficiency of health care delivery. As this field rapidly expands, it is critical for us to develop theoretically based interventions and to provide evidence that digital health tools are acceptable and effective, for both clinicians and patients. EDHI’s vision is for digital health to be an evidence-based, effective and well-integrated tool for creating and restoring health.

IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE)

Contact: Jennifer Tidey, Ph.D.

IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE)

Clinical Research Resources, Addiction & Disease
Established in 2019, the Center for Addiction and Disease Risk Exacerbation (CADRE), is a federally funded NIH Center of Biomedical Research Excellence (COBRE). Through its affiliation with the Center for Alcohol and Addiction Studies at the Brown University School of Public Health, CADRE is investigating mechanisms whereby substance use impacts disease, using multi-disciplinary methods, including behavioral and physiological laboratory-based approaches across several substances of abuse.

IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE)

Contact: Jennifer Tidey, Ph.D.

Analyzer - Automated Immunoassay System

ProteinSimple - Ella Next Generation ELISA system
The Ella mutiplex analyzer allows for multi-plexing of multiple biomarkers on the same cartridge. Rather than performing a separate ELISA for each biomarker with more sample volume to run in triplicate, the ELLA can multi-plex biomarkers in triplicate within a single well, increasing the amount of data that can be generated from clinical samples.

Lentivirus Construct Core (Legorreta Cancer Center at Brown University)

Contact: Olin Liang, Ph.D.

Design and production - COVID-19 Pseudovirus

Service

Lentivirus Construct Core (Legorreta Cancer Center at Brown University)

Contact: Olin Liang, Ph.D.

Cell entry assays - COVID-19 Pseudovirus

Service

Lentivirus Construct Core (Legorreta Cancer Center at Brown University)

Contact: Olin Liang, Ph.D.

SARS-CoV-2 spike and human ACE2 constructs

Service

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Biological Safety Cabinet

Labconco Purifier Logic Series Biological Safety Cabinet
Provide personnel, product and environmental protection from hazardous particulates and agents that require biosafety level 1 or 2 containment.

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Workstation - Laboratory and office space

Mansfield Bio-Incubator
Mansfield Bio-Incubator is a non-profit organization whose mission is to facilitate and assist the creation, growth, and success of the next generation of biotech companies. Our incubator assists these companies and nurtures entrepreneurial and economic development in the community by maintaining affordable lab and office space, services, training, mentoring, and a network of professional advisors. Shared and private office and lab space are available, with additional space coming online in 2021. More information on the membership rates can be found here. https://www.bioinc.org/membership-rates-2

Lifespan - Bradley Hospital
FacilityInstrument/Service/Resource Unit
Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Research - Child Development and Mental Health Research

Clinical Research Resources, Child Development
The Bradley Hasbro Children's Research Center (BHCRC) encompasses a broad spectrum of research programs that share a commitment to studying the impact of psychological factors on the growth and development of children and their families. BHCRC investigators are exploring new insights into the genetic roots of autism; finding pediatric bio-behavioral markers of bipolar disorder; creating effective therapies for OCD; devising effective prevention strategies for adolescent sexual risk behaviors and obesity; and much more. Areas of interest include child and adolescent psychiatric disorders, forensic issues and juvenile justice, pediatric behavioral health, biological basis of psychiatric disorders, prevention and early intervention, and health services research.

Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Research - Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program

Clinical Research Service, Pediatric Imaging
The goal of the Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program is to identify biological and behavioral markers of psychiatric illness in children and adolescents in order to improve diagnosis, treatment, and prevention of these conditions.

Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Research - Rhode Island Consortium for Autism Research & Treatment (RI-CART)

Clinical Research Resources, Autism
The Rhode Island Consortium for Autism Research & Treatment (RI-CART) is working to improve the lives of Rhode Islanders with autism spectrum disorder and related neurodevelopmental disorders by promoting collaborative, cutting-edge research, improving health care and support services, and providing data-driven education and advocacy. We’re a community of families and individuals, researchers, clinicians, educators, and local agencies focused on both today’s and future generations.

Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Research - Bradley Hospital Sleep and Chronobiology Research Laboratory (Sleep Lab)

Clinical Research Resources, Sleep
Sleep for Science is a program of research focusing on understanding how sleep patterns are shaped and how they affect other activities, functions, and biological processes. Our research is chiefly about sleep patterns and processes in young humans – children, teens, and young adults.

Bradley Hasbro Children's Research Center Resources

Contact: Gregory K. Fritz, MD

Research - Developmental Disorders Genetics Research

Clinical Research Resources, Developmental Genetics
The Developmental Disorders Genetics Research Program was established in the fall of 2009 by Brown University to facilitate advances in translational research concerned with the genetics of developmental disorders. 

(Lifespan - Hasbro Children's Hospital)
FacilityInstrument/Service/Resource Unit
Program for Environmental influences on Child Health Outcomes (ECHO)

Contact: Phyllis Dennery, MD

Program for Environmental influences on Child Health Outcomes (ECHO)

Clinical Research Resources, Environmental Influences on Child Health
The ECHO program investigates how exposure to a range of environmental factors in early development — from conception through early childhood — influences the health of children and adolescents.

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
IDeA COBRE on Opioids and Overdose

Contact: Heather Wunschel

Special Populations Core

Service
The Special Populations Core (SPC) provides infrastructure to recruit and retain vulnerable and underserved individuals, builds capacity in the ethical conduct of research with vulnerable populations, and serves as a centralized resource for training and outreach regarding the conduct of research among individuals most impacted by overdose and opioid-related harms.

Emergency Medicine Research Laboratory

Contact: Gregory Jay

Research - Emergency Medicine Research Laboratory Resources

Clinical Trials Support, Emergency Medicine
The research program in the Department of Emergency was established to support investigator-initiated research and pharmaceutical, biologic and biomedical device trials. The program is supported by a Research Program Administrator, two pre-award Research Administrators, a Clinical Research Supervisor, and a staff of Clinical Research Assistants. The department maintains clinical research space within emergency departments as well as fully-equipped basic science laboratories, and has ongoing collaborations with Brown University and other hospital departments.The main focus areas of the Department of Emergency Medicine research program are (1) injury prevention and control, (2) cardiovascular, neurologic, and resuscitation science, (3) pediatric, age, and gender specific care, and (4) healthcare systems science.

Diagnostic Imaging Research

Contact: Glenn A. Tung, MD

Research - Diagnostic Imaging Research Resources

Clinical Trials Support, Diagnostic Imaging
The Division of Imaging Research has successfully completed both federally-funded and industry-sponsored research trials. The Division has participated in cancer imaging trials that include screening studies and studies looking at the efficacy of various imaging modalities.The Division has participated in studies with pharmaceutical companies on phase I, II, and III trials. These studies include both diagnostic and cancer treatment drugs. We have also worked with various device manufacturers that are seeking pre-market and post-market Food and Drug Administration approval for medical devices. In addition, the Division has participated in several blood biomarker studies.

BioBank, BrainTissue

Contact: Ivana Delalle, MD, PhD

BioBank - Brain Tissue Resource Center

Clinical Research Resources, Brain Tissues
A brain tissue resource center (BTRC) (often referred to as a brain bank) is a collection of human tissue specimens from the nervous system: the brain, spinal cord, muscle and peripheral nerves. The facility is engaged in a variety of functions; rapid specimen transport, tissue processing, state-of-the-art preservation methods and database management. A variety of experts, research doctors, neuropathologists and laboratory specialists, plan and manage the BTRC. Strict protocol is imposed on outside vendors whenever their services are required, particularly with respect to rapid specimen transport.

IDeA COBRE on Opioids and Overdose

Contact: Heather Wunschel

IDeA COBRE on Opioids and Overdose

Clinical Research Resources, Opioids and Overdose
The COBRE aims to develop and sustain a vibrant interdisciplinary center of research excellence on opioids and overdose. The COBRE will support the selection, mentorship, and career development of junior investigators performing research in the area of opioids and overdose. The Center will bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work closely together to establish a center of excellence in an area of clinical research that is of critical public health importance.

Lifespan-The Miriam Hospital
FacilityInstrument/Service/Resource Unit
Center for AIDS Research (CFAR) - Providence/Boston

Contact: Vicki C. Godleski

Research - Basic Sciences, HIV research

Clinical Research Service, HIV Research
The Basic Sciences Core builds and supports collaborative research and synergy between basic, translational clinical and behavioral investigators as well as other multidisciplinary scientists, by providing laboratory, consultation and mentoring services. Services include; Viral load measurement, STI testing, Genital tract specific assays, Biologic specimens collection techniques, HIV-1 and 2 drug resistance assays, Identification of HIV dependency factors (HDF), Cell culture, Viral stocks, Immune activation, Laboratory Consulting, Training and Mentoring. Additional assays may be developed as necessary, please contact the Core Director.

Infectious Diseases Clinical Research Program - The Miriam Hospital

Contact: Pamela Poethke, RN

Research - Infectious Diseases Clinical Research Resources

Clinical Trials Support, HIV and HCV
The Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel. The unit conducts trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C. Other studies offered through our clinical trials unit include pharmaceutical studies to treat hepatitis C, prevent C. difficile infection, and test new methods of diagnosing HIV infection.

Center for AIDS Research (CFAR) - Providence/Boston

Contact: Vicki C. Godleski

Research - BioBehavioral Research Support, HIV

Clinical Research Service, HIV Research
The BioBehavioral Sciences Core (BBSC) provides help with participant recruitment, enrollment, and retention to advance biobehavioral research; services to support innovative medical and behavioral data collection approaches, including methods, tools, and assessments; expertise and services related to regulatory and human subjects’ compliance, and the ethical conduct of research for vulnerable populations; provide expertise and services to support the development, implementation, and evaluation of interventions to improve HIV prevention and continuum of care outcomes; specialized services for the conduct of implementation science research and for performing cost-effectiveness research; PrEP related services and information; and guidance and support for accessing EMR data.

Center for AIDS Research (CFAR) - Providence/Boston

Contact: Vicki C. Godleski

Administration - CFAr

Clinical Research Service, CFAR Coordinating Center
The CFAR Administrative Core has built an HIV infrastructure across the partner institutions and provides oversight of the entire CFAR community with responsibility for sound management, organizational structure, appropriate resource allocation, evaluation and the promotion of inter/multi-disciplinary translational HIV research. Through efficient communication to CFAR membership, the Core manages a highly interactive and collaborative scientific environment across geographically dispersed settings in domestic, national and international sites.

Center for AIDS Research (CFAR) - Providence/Boston

Contact: Vicki C. Godleski

Research - Substance Use Research Core, HIV

Clinical Research Service, HIV Research
The Substance Use Research Core (SURC) offers services and expertise on the methods needed to conduct effective Substance Use (SU)/HIV research. The SURC offers expertise in innovative methods for assessing and analyzing SU, and developing and implementing interventions to address alcohol, tobacco, and other drug use. Services include: expertise in developing research projects that address gaps in SU/HIV priority issues both domestically and globally; advice on training on the most appropriate methods for assessing SU; advice and training on incorporating effective and up-to-date SU interventions; and guidance on addressing ethical issues with SU research including input on IRB protocols and human subject sections of grant applications and access to group trainings.

Center for AIDS Research (CFAR) - Providence/Boston

Contact: Vicki C. Godleski

Research - Biostatistics, HIV

Clinical Research Service, HIV Research
The Biostatistics Core ensures that all research undertaken by Center for AIDS Research (CFAR) investigators uses optimal methods for study design and analysis. The Core provides guidance and collaboration in developing grant applications; collaboration on study design, conduct, and statistical analyses; statistical training and mentoring; facilitation of linkages to potential collaborators; provides guidance and support for accessing EMR data; facilitates access to HIV databases from other centers/programs, and develops novel statistical and epidemiological methods for HIV research.

IDeA COBRE for Stress, Trauma, and Resilience (STAR)

Contact: Gayle Fraser

STAR COBRE for Stress, Trauma, and Resilience

Clinical Research Resources, Stress, Trauma, and Resilience
The STAR COBRE aims to foster transdisciplinary collaborations within Brown University, to provide training opportunities for researchers and clinicians who want to address stress and trauma, to enhance partnerships with local and community stakeholders, and to affect policy at the local, national, and international levels.

Sexually Transmitted Disease Clinic

Contact:

Research - Infectious Diseases Clinical Research


The Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel. We conduct trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C.

IDeA COBRE for Stress, Trauma, and Resilience (STAR)

Contact: Gayle Fraser

Community Collaborative Core

Clinical Research Resources
The Community Collaborative Core will support the overall goals of the STAR COBRE by building critical infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories.

IDeA COBRE for Stress, Trauma, and Resilience (STAR)

Contact: Gayle Fraser

Technology, Assessment, Data, and Analysis Core (TADA)

Clinical Research Resources
The TADA Core will offer unique expertise in leveraging technology for observational, laboratory, and intervention studies critical for (1) obtaining ecologically-valid data on stress exposures, behavioral and physiological responses with high temporal resolution, (2) novel approaches to digital phenotyping, and (3) electronically-delivered adaptive interventions.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Clinical Pharmacokinetics Research Laboratory

Contact: Fatemeh Akhlaghi

Pharmacokinetics, Bioanalytical support

Clinical Research Resources, Pharmakokinetics
The Clinical Pharmacokinetics Research Laboratory is equipped with two UPLC-MS/MS and one quadrupole-time-of-flight mass spectrometer (ESI-QTOFMS) systems capable of measuring the concentration of small molecule xenobiotics and their metabolites as well as endogenous or therapeutic peptides and proteins. To date, this laboratory has developed various assays for the quantification of up to 60 different compounds and validated these assays according to guidelines by the Food and Drug Administration of the United States. The laboratory is proficient in providing analytical support for on-going pre-clinical and clinical studies and during different stages of a drug development project.

Clinical Pharmacokinetics Research Laboratory

Contact: Fatemeh Akhlaghi

Pharmacokinetics Consultation

Clinical Research Resources, Pharmakokinetics
The laboratory is capable of providing support for the design and implementation of pre-clinical and clinical pharmacokinetics studies as well as design and conduct of ancillary in vitro studies (protein binding and microsomal incubations to characterize phase 1 or 2 metabolism). With extensive background in pharmacokinetics modeling and simulation using NONMEM, WinNonlin and Simcyp softwares, the laboratory can provide a valuable resource for on-going or completed clinical studies. Additional data analysis capabilities includes in-vitro in-vivo correlation (IVIVC) and bioequivalence analysis.

Institute for Immunology and Informatics (iCubed)

Contact: Barbara Muhitch

Research - Immunology and Informatics Resources

Clinical Research Resources, Immunology and Informatics
iCubed’s research focuses on creating new and safer vaccines. We also explore new methods of predicting and treating adverse immune responses. iCubed supports a wide variety of training efforts that provide opportunities to advance women and students in science which include unique technology toolkits and hands-on laboratory experiences.

VA Providence Healthcare System
FacilityInstrument/Service/Resource Unit
Clinical Research and Development Service

Contact: Gaurav Choudhary

Research - Clinical Research and Development Service Resources

Clinical Research Resources, Veteran Population
The VA Research's fundamental mission is to advance the healthcare of Veterans. The Providence VA Medical Center has a large funded research and development program, including studies in Rehabilitation Medicine, Cardiology, Mental Health, Neuroscience, Substance Abuse, Health Services & Economics, and Pulmonary Disease. These studies enhance our ability to provide state-of-the-art techniques and treatments to our patients. At the same time, the research program helps Providence VAMC recruit and retain the highest quality health care professionals who treat our Veterans in the VA Clinics on a daily basis.

DNA Sequencing

Brown University
FacilityInstrument/Service/Resource Unit
Genomics Facility - Brown

Contact: Christoph Schorl, PhD

DNA Sequencer

Illumina - NextSeq550
The NextSeq550 Next Generation Sequencing system is a high throughput bench top sequencer that provides accurate fast sequencing data, and by employing flexible run configurations it can be easily adopted to a researcher’s needs depending on their required read length and sequencing depth. Reagents are available in a mid-output and a high output mode resulting in maximum cluster numbers of 400 million (high output) and 130 million (mid output) clusters (reads).

Lifespan-The Miriam Hospital
FacilityInstrument/Service/Resource Unit
Biorepository Core

Contact: Evgeny Yakirevich

DNA Sequencer

Illumina iseq 100 Illumina assay instrument FS10001514
Genotypic profiling by whole genome sequencing 16S metagenomic sequencing. Antimicrobial resistance detection by gene sequencing

Providence College
FacilityInstrument/Service/Resource Unit
PC - Hickey Hall Labs

Contact: Charles Toth

DNA Sequencer

ABI Prism 3100 Genetic Analyzer
Used for DNA sequencing and fragment analysis. The ABI PRISM 3100 Genetic Analyzer is an automated capillary electrophoresis system that can separate, detect, and analyze up to 16 capillaries of fluorescently labeled DNA fragments in one run.

VA Providence Healthcare System
FacilityInstrument/Service/Resource Unit
Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

DNA Sequencer

Ion Gene Studio/S5 with Ion Chef/ThermoFisher
Next Generation Sequencer

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

DNA Sequencer

Qiagen Pyromark Q96 ID
Quantitative analysis of genetic/epigenetic DNA modifications using Pyrosequencing technology

Engineering

Brown University
FacilityInstrument/Service/Resource Unit
Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Chemical Hood

Wet chemistry workbenches equipped with fume hoods for lithography
The Microelectronics Facility has a number of wet chemistry workbenches equipped with fume hoods for chemical processing (cleaning, wet etching, electroplating, anodization, etc) employed in the fabrication of semiconductor and nanomaterials devices. These hoods also house spinners for applying photoresist for lithography and other polymers.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Lithography - Mask Aligner

Karl Suss MJB3 UV300 Mask Aligner for Lithography
The Karl Suss MJB3 UV300 3-inch mask aligner is designed for high-resolution photolithography, with a 350 W mercury lamp and Suss diffraction-reducing exposure optics. The primary exposure wavelengths of 365 or 403 nm lead to roughly 1 µm minimum feature size. For smaller feature sizes, electron-beam lithography is available in the Electron Microscope Facility.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Lithography - Maskless Aligner

Heidleberg MLA 150 Maskless Aligner
MLA150 Maskless Aligner is a high-speed, direct-write, optical lithography system to fabricate nano- and micro-patterned materials and surfaces at low-cost and over large areas. The instrument comprises two laser illumination modules, optical systems to steer the laser beams and control exposure, integrated cameras for high-accuracy alignment to pre-existing structures, automated translation stage, real-time pneumatic autofocus, and a class 10 climate controlled chamber to achieve photo-lithographically defined structures with feature size ≤1μm.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Lithography - Flexible Mylar-Mask

Newport-Oriel flexible Mylar-Mask Lithography System
Newport-Oriel flexible Mylar-Mask Lithography System is designed for printing from flexible Mylar masks onto substrates as large as 4” x 4” square or 5” diameter. It is capable of printing 5-micron features with placement and alignment to approximately 2 microns with appropriate alignment marks.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Evaporator - Thin Film Deposition

Electron Beam Evaporator
This system deposits thin films of inorganic materials, usually metals, from a four-pocket electron-beam source inside a high vacuum (cryopumped) chamber. Deposition rates of up to 0.1 micron/minute are possible for some materials. This system can easily accomodate relatively large, 3-D objects and has substrate heating to 300 C for flat substrates. Restrictions on what materials may be evaporated are somewhat less stringent than for our other evaporators.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Lithography - Imprinter

NIL Technology Nano Imprinter
The Nano Imprinter system offers thermal and UV nanoimprint and imprinting in vacuum if needed. The system transfers the patterns, usually nanohole or nanopillar arrays, from a silicon stamp to a nanoimprint-polymer-coated substrate by applying heat and pressure.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Evaporator - Thin Film Deposition

Angstrom Organic Evaporator
The Angstrom Resitive-heated Evaporator is a thermal evaporator coupled with a nitrogen glove box. It is for depositing thin organic and inorganic films when either the deposition material or the substrate is adversely affected by moisture or oxygen. Samples and/or evaporants are loaded from a nitrogen glove box maintained at under 10 ppm of oxygen and under 1 ppm of water vapor.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Deposition System - Thin Film Deposition

Cambridge NanoTech Atomic Layer Deposition System
The Cambridge NanoTech Fiji F200 series Atomic Layer Deposition System is a modular medium to high-vacuum ALD system that accommodates a wide range of deposition modes. This tool is currently configured with precursors for metallic and oxide layers of Hafnium, Aluminum, and Tungsten.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Deposition System - Thin Film Deposition

Plasmatherm Model 790, Fluorine Chemistry Reactive Ion Etching Plasma Enhanced Chemical Vapor Deposition System (RIE PECVD)
The PlasmaTherm Model 790 RIE-PECVD system has a computer-controlled single-wafer turbopumped chamber that provides reactive ion etching (RIE) and plasma-enhanced chemical vapor deposition (PECVD) capabilities. RIE is accomplished using fluorine-chemistry gases (CF4, CBrF3, CHF3, SF6, etc.) with up to 500 W RF power. PECVD capability provides low-temperature (up to 350 C) SiO2 and Si3N4 deposition from silane chemistry.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Profilometer - Characterization

DekTak3 Profilometer
The DekTak3 is a computer-controlled surface profile measuring system, which accurately measures step heights from below 50 A to over 50 µm by moving a diamond-tipped stylus over the surface. Equipped with video camera and surface profile analysis software.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Analytical Prober

Karl Suss 200mm Precision Manual Analytical Prober
200mm Precision Manual Analytical Prober. The PM8 provides the stability and resolution required for precise probe positioning. Manual submicron semiconductor failure analysis and in-process testing probe station. Submicron precision and stability with a fine-glide chuck stage and 8 in. x 8 in. X-Y movement. As fast as a motorized stage but with the simplicity and resolution of a manual system. Vacuum Chuck: 8 in. dia. Mitutoyo high magnification microscope with two long working distance objectives. Microscope lifts for easier access to the probes and device under test. The station is fitted with six Wentworth micromanipulators having tungsten needle probes with 3 micron tips.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Deposition System - Thin Film Deposition

Lesker Lab 18 thin film deposition system
The Lab-18 thin film deposition system is a combined electron-beam evaporator and RF sputtering Physical Vapor Deposition (PVD) system that makes high quality, research-grade metallic, semiconducting, and dielectric thin films. The Lab 18 includes a four-pocket electron beam evaporator as well as two 2” magnetron sputter sources. Two mass flow regulated gas lines provide for control of chamber pressure and gas composition for reactive sputtering.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Plasma Etching System

Inductively Coupled Plasma RIE System
The SPTS LPX is an inductively-coupled plasma (ICP) reactive-ion etcher (RIE). It can etch high-aspect ratio structures in a wide range of materials, including silicon, silicon dioxide, and silicon nitride. This system is configured with a range of gases for reactive- and physical-ion etching, including SF6, C4F8, CF4, O2, and Ar. The LPX-ICP system is equipped with a single-wafer load-lock transfer arm for 100mm wafers; smaller wafers and small pieces may be processed on the system using a carrier wafer.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Characterization - Thin Film Deposition

JA Woollam, M-2000 Ellipsometer Variable Angle Research Grade
The JA Woollam, M-2000 Variable Angle Research Grade ellipsometer measures angle- and wavelength-dependent reflectivity and transmissivity data over a wide spectral range (from ultraviolet to near-infrared) that is analyzed to directly to determine optical properties of single- and multi-layer films (e.g., their thickness and complex wavelength-dependent refractive index), which provide insight into their underlying chemical, electronic, and mechanical properties.

Nanofabrication Central Facility (NCF)

Contact: Michael Jibitsky

Furnace

Wet and Dry Oxididation
Quartz tube furnace for thermal oxide growth on silicon by a chemical reaction between the silicon and either dry oxygen or water vapor at atmospheric pressure. The typical temperature range for the oxidation of silicon for wafer fabrication 750˚C to 1100˚C. The tubes accommodate multiple 2 inch wafers.

NanoTools Facility

Contact: Hector Garces

X-Ray Diffraction System, 2 Dimensional

Bruker, D8, XPS
This Bruker D8 Discover X-ray Diffraction System can be configured with a point and line source x-rays. A Vantec 500 2D area detector or a LinxEye (0D, 1D)detector can be used for the analysis. The system is suitable for texture, stress, and micro-x-ray diffraction as well as for orientation and epitaxy studies. The instrument has in-situ capabilities for studies at low/high temperature and under vacuum to study properties as a function of time, temperature, gas environment or vacuum. A capillary spinner stage is also available for investigations of air sensible materials with the sample prepared in a capillary glass.

NanoTools Facility

Contact: Hector Garces

X-Ray Diffration System, High-Resolution

Bruker, D8, XPS
This Bruker D8 Discover X-ray Diffraction System includes a line source configuration system with a LinxEye (0D, 1D) detector and a Scintillator detector. The system is suitable to determine thickness, crystallographic structure and strain in epitaxially thin films as well as high resolution analysis of bulk materials. X-ray reflectometry (XRR), high resolution XRD, grazing incidence diffraction (GI-XRD), in-plane GID (IGID) and reciprocal space mapping (RSM) are some techniques that can be performed with this configuration. High resolution is obtained using parallel beam optics: Goebel mirror, monochromators, soller slits and analyzer crystals. 

NanoTools Facility

Contact: Hector Garces

Microscope - Atomic Force

Asylum, MFP-3D, AFM
The Asylum MFP-3D Origin atomic force microscope (AFM) is a multi-mode instrument. It is equipped with a closed loop operation in all three axes with high precision, resolution and low noise operation. The closed loop Z scanner eliminates hysteresis. The AFM provides a 90 µm X and Y range (< 0.5nm noise) and 15 µm Z range (Z sensor, 0.25 nm noise) and detector noise <15 pm. It also includes Inverted optical lever design that eliminates interference artifacts and a low-coherence infrared (860 nm) super-luminescent diode (SLD) light source (class 1M). Applications include dual AC resonance tracking (DART), electric force microscopy (EFM), force mapping mode, lateral force microscopy (LFM), magnetic force microscopy (MFM), kelvin probe force microscopy (KPFM), piezo-response force microscopy (PFM), and conductive AFM (C-AFM) with ORCA.

NanoTools Facility

Contact: Hector Garces

Microscope - Confocal Raman

Witec, Alpha 300 M+, CRM
The Witec Alpha 300 Confocal Raman Microscope is equipt with different scan modes for local Raman spectra, mapping distribution of phases within a sample and with 3D image generation and depth profile of samples. The depth profiling and 3D imaging capabilities of the Alpha 300 provide the ability to analyze the interior of transparent samples without microtome sectioning or freeze etching. Multi-wavelength coupler for selection of 532 nm or 633 nm wavelength laser sources and a Ray Shield coupler for measurements of Raman spectra at low wave numbers. Fast Raman imaging with integration time in the milliseconds order per spectrum. A heating stage for in-situ measurements in the temperature range 25°C to 1400°C with a thermal stability of ± 0.3°C.

NanoTools Facility

Contact: Hector Garces

Spectrometer - Electron Paramagnetic Resonance (EPR)

Bruker, EMX+, EPR
The Bruker EMX Electron Paramagnetic Resonance (EPR) Spectrometer is equipt for the Technique for the direct detection of paramagnetic species. The EMX EPR has a digital resolution of 24 bit center field, a field sweep up to 256,000 points, high-sensitivity resonator with irradiation window, dual channel, simultaneous detection of 1st and 2nd harmonic, and sensitivity S/N up to 2000:1. The system has a helium temperature control system for low temperature measurements in the temperature range 3.8 K (~-269 °C) to 300 K (~27°C). Applications span a wide range of areas an include kinetics of radical reactions, oxidation and reduction process, polymerization reactions, degradation of compounds by light, organometallic compounds and catalysis, free radicals, and antioxidants and radical scavengers.

Joint Engineering Physics Instrument Shop (JEPIS)

Contact: Michael Packer

Fabrication - Machine Shop

Service that provides machine shop capabilities
The Joint Engineering Physics Instrument Shop (JEPIS) is a specialized service center providing assistance in the development of experimental instruments, research projects and instructional classes. The JEPIS services are offered to faculty, students and staff on the Brown University campus, and is also available to outside academic/hospital users. JEPIS offers all of the basic machine shop capabilities, including Wire EDM and Rapid Prototype printing. JEPIS also offers CNC design consultation, hands on training and instruction through non-credit basic machine shop course and an advanced course geared toward Graduate Students. The Student Shop provides students with a strong base for their experimental studies. The JEPIS staff is available to give general advice and assistance to the Brown Students and Staff in the finding of sources for the materials and devices they require for their projects or instructional classes. Access to the facility is on a user fee basis of an hourly fee for labor plus materials.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - Atomic Force

Shimadzu SPM-9700
Scanning probe microscope for atomic force microscopy, magnetic force microscopy, liquid cell analysis, Kelvin force microscopy, I/V curves, nanomechanical measurements

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Spectrometer - Energy Dispersive X-Ray Fluorescence

Shimadzu EDX-8100
Energy dispersive X-ray fluorescence of powders, solids and liquids. Ambient pressure, vacuum and He atmosphere

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - Scanning Transmission Electron

JEOL F200
Scanning transmission electron microscope with cryogenic capabilities, direct electron camera (Gatan K3), Energy dispersive X-ray spectroscopy (JEOL), electron energy loss spectroscopy (Gatan). Sub nanometer resolution, 80 and 200 kV operation, TEM, STEM and diffraction

MakerspaceURI

Contact: makerspace@etal.uri.edu

Tools - Router - computer numerical control (CNC)

Inventables X-Carve

MakerspaceURI

Contact: makerspace@etal.uri.edu

Computers

DELL high-performance PCs (4), Alienware PC (3)

MakerspaceURI

Contact: makerspace@etal.uri.edu

Cutter - Laser

GCC Laserpro Spirit LS

MakerspaceURI

Contact: makerspace@etal.uri.edu

Sewing Machines/ Embroidery

Brother XM2701 Sewing Machine (2), Brother PE-770 Embroidery System

Flow Cytometry

Brown University
FacilityInstrument/Service/Resource Unit
Flow Cytometry and Sorting Facility

Contact: Kevin Carlson

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACS Aria III
Cell counting, sorting, biomarker detection. The FACSAria has five air-cooled lasers at 351nm, 488nm, 561nm, 633nm, and 407nm allowing multicolor analysis of up to 20 parameters. It can sort 1 to 4 populations simultaneously and is equipped with an Automated Cell Deposition Unit, an Aerosol Management System and a refrigeration system. It can accept various sample input tubes including 1 mL microtubes, 12 x 75-mm test tubes, and 15 mL tubes into the sample and collection chambers.

Flow Cytometry and Sorting Facility

Contact: Kevin Carlson

Flow Cytometer - Benchtop Analyzer

Cytek Aurora
The Cytek Aurora can analyze similar and very similar spectral emitting fluorochromes. Instead of analyzing small chunks of fluorescence and calculating fluorescence spill over, the Cytek Aurora looks at the full spectrum emitence of each fluorochrome. This allows colors that would normally be unusable with each other to be run in tandem. The Cytek Aurora can analyze up to 38 fluorochromes, 41 parameters (FSC, 488 SSC, 405 SSC).

Flow Cytometry and Sorting Facility

Contact: Kevin Carlson

Fluorescence Acticated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACS Celesta
Cell counting, biomarker detection. The FACSCelesta has three air-cooled lasers at 488nm, 561nm and 407nm allowing multicolor analysis of up to 15 parameters that has an attached high throughput system (HTS) that allows users to analyze samples directly from a 96 well plate.

Care New England - Women and Infants Hospital
FacilityInstrument/Service/Resource Unit
Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACSCanto
Analytical Flow Cytometer: 2 lasers, 6 colors

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Fluorescence Activated Cell Sorter (FACS)

Thermo Scientific Attune NXT
Analytical flow cytometer: 4 lasers, 14 colors, with 96 well plate handler capability

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Flow Cytometry Core

Flow Cytometry and Cell Sorting
The Flow Cytometry Core facility is dedicated to advancing research projects requiring cell sorting and/or analysis of cell populations by flow cytometry. The core offers training on and access to shared use instrumentation for analytical flow cytometry, services for fluorescence activated cell sorting (FACS) as well as technical consultation and support on experimental design, execution, and data analysis.

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson - Accuri Flow Cytometer
This system is equipped with a blue and red laser, two light scatter detectors, and fluorescence detectors with optical filters optimized for FITC, PE, PerCP, and APC. The user does not need to adjust detector voltages and there is a wide dynamic range of digitally collected data (7.2 decades).

Flow Cytometry Core - Rhode Island Hospital

Contact: Mark Dooner

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences LSRII Analyzer/Flow Cytometer
Digital, 4 laser (355nm, 405nm, 488nm and 635nm) flow cytometric analysis system with 10 fluorescent channels plus 2 scatter channels. BD FACSDiva software with digital compensation and ModFit software for cell cycle analysis.

Flow Cytometry Core - Rhode Island Hospital

Contact: Mark Dooner

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences Influx Cell Sorter
5 laser system (355nm, 405nm, 488nm, 561nm and 638nm) for simultaneous detection of up to 14 parameters. Sorts up to 4 different cell populations. Capable of single cell deposition into many different sized culture plates (96 or 384 well plates, etc). Equipped with a small particle objective for FSC size determination down to 0.5 micrometers. Enclosed in a biosafety hood. The sorter separates particles on the detection of fluorescent markers on particles such as cells, chromosomes, bacteria or nuclei. Then the collected cells are suitable for downstream analysis either in molecular applications like protein assays and PCR, or used in viable assays such as tissue culture or injected into in vivo models. Generated data may also be used to determine percentages of interrogated populations. The sorter can separate populations into tubes (1.5ml, 4ml, 15ml, 50ml), multi-well plates (6, 24, 48, 96, 384), or directly onto microscope slides.

Flow Cytometry Core - Rhode Island Hospital

Contact: Mark Dooner

Mass Cytometry

Fluidigm Helios (CyTOF) Mass Cytometry
Mass cytometry combines the technologies of flow cytometry with that of mass spectrometry. It applies nebulization, aerosolization and ionization to cells labeled with heavy metal isotope-conjugates, allowing for ion separation based on their mass:charge ratio and quantification of each isotope on a per cell basis ultimately determining properties of a cell population at a single-cell resolution. The technique of mass cytometry is powerful, as it can analyze more cellular targets without the problem of compensation as seen in flow cytometry. The Helios is capable of simultaneously analyzing up to more than 50 parameters both on cell surface and intracellularly.

Flow Cytometry Core - Rhode Island Hospital

Contact: Mark Dooner

Training and Technical Assistance

Service

Lifespan-The Miriam Hospital
FacilityInstrument/Service/Resource Unit
Animal Models Core

Contact: Gerard Nau, MD

Flow Cytometer

Amnis CellStream Luminex Flow Cytometer
The CellStream flow cytometer has single tube and 96 well plate capabilities with automatic compensation. Equipped with 405nm, 488nm, 532nm, and 642nm lasers and 16 fluorescent channels. Handles BSL-1 and fixed samples from BSL-2 experiments.

Providence College
FacilityInstrument/Service/Resource Unit
PC - Hickey Hall Labs

Contact: Charles Toth

Fluorescence Activated Cell Sorter (FACS)

Flow Cytometer- Accuri C6
The BD Accuri C6 is a personal flow cytometer that is easy to use, simple to maintain, and affordable.

Roger Williams University
FacilityInstrument/Service/Resource Unit
RWU Lab Spaces

Contact: Nancy Breen

Fluorescence Activated Cell Sorter (FACS)

Millipore Guava easyCyte Flow Cytometer
Cell sorting and analysis

Salve Regina University
FacilityInstrument/Service/Resource Unit
Salve Regina Biology and Biomedical Sciences

Contact: Anne Reid

Fluorescence Activated Cell Sorter (FACS)

Millipore Guava EasyCyte 8 Flow Cytometer
Single blue (488 nm), dual blue and red (642 nm), or triple blue, red, and violet (405 nm) excitation lasers provide up to 12 simultaneous detection parameters, including 10 fluorescent colors plus forward and side scatter for size and granularity determination. The guava easyCyte family also meets your sample throughput needs by offering both single sample and multi-sample processing.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Marine Science Research Facility

Contact: Dawn Outram

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences Influx Flow Cytometer and Cell Sorter
Measures light scatter and fluorescence of cells. Sorts cells based on measured properties.

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Fluorescence Activated Cell Sorter (FACS)

Becton Dickinson (BD) Biosciences FACS Verse Flow cytometer
Fluorescence-activated cell sorting

Cell Analysis and Sorting Core

Contact: Alan Rothman, M.D., Research Professor

Flow Cytometer

Miltenyi MACSQuant-10 Analytical Flow Cytometer
Analytical flow cytometry- 3 lasers, 10 parameters (8 colors, FSC, SSC)

Cell Analysis and Sorting Core

Contact: Alan Rothman, M.D., Research Professor

Cell Sorter - Magnetic-Activated Cell Sorter (MACS)

Miltenyi AutoMACS
Automated cell sorter for cell suspensions labeled with magnetic beads.

Cell Analysis and Sorting Core

Contact: Alan Rothman, M.D., Research Professor

Flow Cytometer

BD LSRII Flow Cytometer
Analytical flow cytometric analysis; 4 lasers (blue (2), violet (4), red (3) and yellow green (5)) which allows for analysis of up to 14 different fluors (# listed in parentheses for each laser)

VA Providence Healthcare System
FacilityInstrument/Service/Resource Unit
IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Flow Cytometer - Magnetic-Activated Cell Sorter (MACS)

Miltenyi MACSQuant Analyzer 7 Flow Cytometer
The MACSQuant Analyzer is a powerful benchtop flow cytometer for highly sensitive, multiparameter cell analysis. MACSQuant Analyzers offer fully automated instrument setup via pre-set calibration and compensation programs. Automated startup, shutdown, and cleaning cycles make for hassle-free instrument housekeeping. The MACSQuantify Software provides a powerful and easy-to-use user interface for instrument control, data acquisition, and fully automated analysis.

GeoChemistry

Brown University
FacilityInstrument/Service/Resource Unit
Mass Spectrometry Facility (Brown Chemistry)

Contact: Lisa Chen

Gas Chromatograph - Mass Spectrometer (GC - MS)

Hewlett-Packard (Agilent) 6890 GC/5973 MSD
This system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 450 Da).

Mass Spectrometry Facility (Brown Chemistry)

Contact: Lisa Chen

Liquid Chromatography - Mass Spectrometer (LC - MS)

Agilent 6530 Mass QTOF
This system consist of Agilent 1260 infinite HPLC and Agilent 1260 infinite nanoglow LC/chipcube nanoelectrospray MS interface, and 6530 Accurate Mass Q-TOF mass spectrometer. This instrument can detect and identify compounds in amounts smaller than two trillionths of a gram (2 picograms), making the Agilent 6530 a powerful tool for food safety, toxicology and other measurements where minute amounts of compounds must be identified.

Mass Spectrometry Facility (Brown Chemistry)

Contact: Lisa Chen

Mass Spectrometer

Thermo LXQ linear ion trap with Surveyor HPLC system
The LXQ has capabilities similar to the conventional 3D ion trap such as LCQ Deca. It is based on linear ion trap technology that has faster cycle time. It is capable of data-dependent LC/MSn analysis.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Analyzer - Discrete Analyzer

Westco Smartchem 200
Used to determine Nitrate/Nitrite, Phosphate, Ammonia, Silicate, and other nutrient concentrations in water samples and soil extracts.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Analyzer - Elemental Analyzer

Thermo Scientific, FlashSmart EA
Analysis of carbon, nitrogen, and sulfur concentration of solid samples

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Analyzer - Inorganic Carbon Analyzer

UIC, INC Inorganic Carbon Analyzer
Measures total inorganic carbon by automated acidification and coulometric detection in a wide variety of sample matrices. Solid samples ranging from low ppm to 100% inorganic carbon can be analyzed with this system.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Analyzer - Mercury Analyzer

Milestone DMA-80 Direct Mercury Analyzer
Determines mercury content of solid and liquid samples.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Analyzer - Water Isotope

Picarro L1102-I
Measures delta deuterium/hydrogen (D/H) ratio and delta 18O/16O in liquid water

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Sample Preparation - Freeze Dry System

Labconco FreeZone 6 Liter
For removing water and other solvents from frozen samples by sublimation.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Liquid Chromatography System

Dionex DX500
Ion chromatography analysis of anions and cations in marine and freshwater samples

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Sample Preparation - Microwave Digestion System

Milestone Ultrawave
Used to digest solid samples (soils, sediments, rocks, plants, tissues), for elemental analysis.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Spectrometer - Atomic Absorption Spectrometer-Graphite Furnace (GFAAS)

Perkin Elmer AAnalyst 600 Graphite Furnace
This spectrometer is useful for measuring trace levels of metals in water and soil.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

Spectrometer - Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES)

Thermo Scientific iCAP 7400 DUO ICP-OES
Analysis of most elements with atomic weights above 10.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

X-Ray Fluorescence - Handheld

Innov-X Systems Alpha 4000 Handheld
Non-destructive elemental analysis on a variety sample types for concentrations of some metals ranging from about 20 ppm to 10%.

Environmental Chemistry Facility

Contact: Marcelo Alexandre

X-Ray Fluorescence - Handheld

Olympus Delta Professional Handheld
Non-destructive elemental analysis on a variety sample types for concentrations of elements greater than 10 ppm.

Mass Spectrometer Analytical Facility

Contact: Soumen Mallick

Analyzer - Laser Ablation

Photon-machines Analyte G2, 193 nm excimer laser ablation
This 193 nm wave-length excimer laser allows us to perform in-situ analysis on a solid sample with a beam diameter as small as 3µm. To determine the elemental abundances the laser is coupled with the single collector inductively coupled plasma mass spectrometer ICPMS and to determine the isotope ratios the laser is coupled with multi collector ICPMS.

Mass Spectrometer Analytical Facility

Contact: Soumen Mallick

Mass Spectrometer

Thermo Scientific Quadrupole inductively coupled plasma mass spectrometer, ICP-MS, X-series-2
This is a single collector ICP-MS that allows us to measure precise elemental composition at sub-ppb level concentration.

Mass Spectrometer Analytical Facility

Contact: Soumen Mallick

Mass Spectrometer

Thermo Scientific Multi-collector inductively coupled plasma mass spectrometer, ICP-MS, Neptune Plus
This is a multi-collector ICP-MS equipped with nine Faraday cups and eight ion counters, which allows us to monitor multiple masses simultaneously providing precise isotope ratio measurement.

Benedum Stable Isotope Facility

Contact: Steven Clemens

Mass Spectrometer, Isotope Ratio

ThermoFisher (Finnigan) 253+ dual inlet Isotope Ratio Mass Spectrometer with automated sample reaction device for up to 48 samples and with Kiel IV Carbonate interface and PoraPak purification trap.
Instrument primarily dedicated to the measurement of the stable isotopes of carbon and oxygen on inorganic carbonates as well as clumped oxygen isotopes. The facility accommodates projects both internal and external to Brown including analysis of terrestrial and marine material. The vast majority of samples analyzed are funded through external grants but we also facilitate a significant number of small unfunded, exploratory, analyses to help construct proof-of-concept data sets in preparation for proposals.

Mass Spectrometer Analytical Facility

Contact: Soumen Mallick

Workstation - Clean lab, metal free

Pico Trace Clean Lab
This Clean Lab is equipped with Millipore water filtration system that provides greater than 18MΩ Milli-Q water. The working stations in this Clean Lab meet ISO class 4 standard (equivalent to FS class 10) allowing us to perform ultra-low blank chemical analysis.

Electron Microprobe Facility

Contact: Joseph S Boesenberg

Analyzer - Electron Microprobe

Cameca SX100 Electron Microprobe Analyzer
The Cameca SX-100 electron microprobe is equipped with 5 wavelength dispersive spectrometers (WDS) and a Rontec energy dispersive spectrometer (EDS).The WDS spectrometers each contain two or four diffracting crystals and presently include LTAP, TAP (2), LPET (2), PET, LLIF (2), LIF, LPCO, PC1 and PC2. The last three crystals are used to measure the light elements (boron to sodium). The absolute detection limits for the instrument are approximately 50-200 ppm, depending on the element. The EDS spectrometer is capable of detecting all elements above sodium (Na). X-ray element maps can easily be acquired on the microprobe. Using 512x512 pixel maps, up to nine element maps (5 elements on WDS, 4 with EDS), plus a backscattered electron (BSE) image, can be obtained simultaneously. Maximum resolution on any one map is one micron per pixel. Utilizing the coordinate system, maps of entire thin sections can be generated.

Mass Spectrometry Facility (Brown Chemistry)

Contact: Lisa Chen

Gas Chromatograph - Mass Spectrometer (GC - MS)

Agilent 5977A GC/MSD System
This system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 1050 Da).

Mass Spectrometry Facility (Brown Chemistry)

Contact: Lisa Chen

Mass Spectrometer

Bruker Autoflex Speed Linear (L) Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometer (MALDI-TOF MS).
The Bruker autoflex Speed is a linear time-of-flight (TOF) mass spectrometer equipped with a matrix-assisted laser desorption ionization (MALDI) ion source. This instrument is routinely used for analysis of organic molecules, natural products, and macromolecules, including recombinant proteins, oligonucleotides, polysaccharides and synthetic polymers.

Good Manufacturing Practice (GMP)

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Cell Immunotherapy and Gene Therapy (CITGT) Good Manufacturing Practice (GMP) Facility

Services and Equipment
The Cell Immunotherapy and Gene Therapy GMP facility supports the manufacture of investigational new drug (IND) products for principal investigators under FDA rules and regulations. 

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Pharmaceutical Development Institute

Contact: Catherine Curtin-Miller

Training Center

Clinical Research Service, GMP education
Providing GMP industrial experience in drug manufacturing and analytical testing for students in various related undergraduate, graduate and adult education programs, as well as industry-specific training in collaboration with pharmaceutical and biotechnology firms.

Pharmaceutical Development Institute

Contact: Catherine Curtin-Miller

GMP analytical testing

Clinical Research Service, GMP analytical
Providing pharmaceutical testing services including turn-key stability studies

Pharmaceutical Development Institute

Contact: Catherine Curtin-Miller

GMP manufacturing

Clinical Research Service, GMP manufacturing
Assisting academic, government and industry partners with the manufacture of solid dose forms for veterinary and human use

Pharmaceutical Development Institute

Contact: Catherine Curtin-Miller

current Good Manufacturing Practice (cGMP) Facility

Service
Rapid expansion in the markets for biologics and small molecule pharmaceutical products has created a critical demand for skilled professionals (from equipment operators to advanced technical and quality assurance personnel) and additional infrastructure to support drug development and manufacturing.  The current Good Manufacturing Practice (cGMP) Facility at the University of Rhode Island (URI) offers a state-of-the-art training, development and manufacturing facility for GMP production of solid oral dosage forms.  

Histology & Pathology

Brown University
FacilityInstrument/Service/Resource Unit
Molecular Pathology Core - Brown

Contact: David Silverberg

Histology/Tissue Processing - Immunolabelling

Service
Immunohistochemistry, Immunocytochemistry, Immunofluoresence, Immunogold, TUNEL Assay

Molecular Pathology Core - Brown

Contact: David Silverberg

Paraffin Embedding Workstation

Leica EG1150C Paraffin Embedding Center
Paraffin embedding

Molecular Pathology Core - Brown

Contact: David Silverberg

Microtome

Leica RM2265 Automated Microtome
Paraffin and plastic sectioning

Molecular Pathology Core - Brown

Contact: David Silverberg

Cryostat

Leica CM3050S Cryostat
Sectioning of fixed and unfixed frozen samples

Molecular Pathology Core - Brown

Contact: David Silverberg

Vibratome

Leica VT 1000S Vibratome
Sectioning of fixed samples

Molecular Pathology Core - Brown

Contact: David Silverberg

Histology/Tissue Processing - Tissue Sample Processing and Embedding

Service
Paraffin Processing and Embedding- automated and manual, Plastic Processing and Embedding, TEM and SEM Processing and Embedding, Frozen Tissue-Embedding in OCT Block, Sample Preparation for Serial Blockface Imaging

Molecular Pathology Core - Brown

Contact: David Silverberg

Histology/Tissue Processing - Sectioning

Service
Paraffin sectioning, plastic sectioning, Frozen/Cryostat prep and sectioning, TEM ultrathin sectioning, Vibratome, Serial and Step sectioning

Molecular Pathology Core - Brown

Contact: David Silverberg

Histology/Tissue Processing - Staining

Service
Hematoxylin and Eosin (H&E), Periodic Acid Schiff (PAS), Masson's Trichrome, Special Stains

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Microtome

Thermo Scientific Shandon Finesse 325 manual microtome
With a lightly balanced flywheel it is ideal for routine paraffin sectioning.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Sample Preparation - Cutter

Buehler-Isomet Cutter
The IsoMet Low Speed Cutter is a precision sectioning saw designed for cutting various types of materials with minimal deformation. Its low kerf loss capability and great versatility in holding all types of sample shapes and configurations, gives today's laboratory a precision sectioning tool capable of cutting viturally any material including brittle or ductile metals, composites, cements, laminates, plastics, electronic devices and biomaterials. The Cutter is equipped with a diamond studded carborundum wheel and Buehler Ecomet 4 grinder/polisher with Automet 2 powerhead.

Rhode Island College
FacilityInstrument/Service/Resource Unit
RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Sample Preparation - Knifemaker

LKB 7800 Knifemaker
Slide/Sample Preparation

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microtome

Leica RM2165 Motorized Rotary Microtome
Slide/Sample Preparation

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microtome

TBS Microtome plus Cryostat
Slide/Sample Preparation

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Analyzer - Live Cell

Roche xCELLigence Real-Time Cell Analysis System
Label free live cell analyzer

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Biological Safety Cabinet

NuAire, Laminar Flow Hood
Cell culture facility

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Cell Counter

Nexcellom Cellometer Vision Cell Counter
Automated cell counter

VA Providence Healthcare System
FacilityInstrument/Service/Resource Unit
IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Respiratory Core

Service
The mission of the Respiratory Core is to develop centralized systems for cardiopulmonary structural/functional assessments and mitochondrial function analysis, with the goal to enhance the productivity and the research impact of CPVB COBRE investigators and others in the state of Rhode Island. We are committed to providing reproducible, economical, and high-quality services. We offer consultation on experimental design, provide cutting edge technological approaches and high-end instrumentation, generate and analyze data.

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Organ Function Core

Service
To provide measurement of heart, lung, and vessel function, in vivo angiogenesis, and transient gene manipulation in vivo. The COBRE Core will provide expertise and state of the art equipment for assessing heart, lung, and vessel function, in vivo angiogenesis, and transient gene manipulation in vivo. The Cell/Organ Core has been measuring heart and lung function using echocardiogram and Flexivent™ methodological approach.

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Cell Isolation and Tissue Culture Core

Service
The function of the Cell Isolation and Tissue Culture Core is to provide efficient, economical, and reproducible isolation of pulmonary and cardiac endothelial cells, fibroblasts, vascular smooth muscle cells, epithelial cells, macrophages; propagation, and phenotypic characterization and function.

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Analyzer - Cell Metabolism

Seahorse Biosciences - XF Extracellular Flux Analyzer
XF instruments analyze mitochondrial respiration and glycolysis in live cells, generating data in just minutes. XF Technology uses solid-state sensors to simultaneously measure both oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in every well. All platforms support injection of up to 4 unique compounds per well.

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Sensing equipment - Electrical Cell Impedance Sensing (ECIS)

Applied BioPhysics, Model 100 and Model ECIS Z Theta
Measures cell impedance using altering currents across cell monolayers and measuring the change in electrical potential. Impedance is calculated using Ohm's law.

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Evaporator

Buchi RotaVapor R215 Evaporator
Rotary evaporator for removing solvents.

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Ventilator - Mechanical

SCIREQ FlexiVent
Contains a computer-controlled precision piston pump that can intersperse mechanical ventilation with a variety of volume and pressure controlled maneuvers to obtain accurate, reproducible measurement of respiratory mechanics for pulmonary research.

Imaging

Brown University
FacilityInstrument/Service/Resource Unit
Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Software - Analysis

Software: Amira 2019
Software for image analysis and 3D visualization

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Sample Preparation - Critical Point Dryer

Ladd Research Industries
Removes liquid from biological specimens for SEM

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Sample Preparation - Glow Discharge Unit

Emitech K100X
Adds a charge to make TEM samples hydrophilic

Magnetic Resonance Imaging (MRI) Facility

Contact: Michael Worden, PhD

Imaging System - Magnetic Resonance Imaging (MRI) Scanner

Siemens 3 Tesla Prisma fit
Brain structure and function in normal and clinical populations as well as studies of other body systems, non-invasive animal imaging and materials science.

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Multiphoton

Olympus FV-1000-MPE Multiphoton Laser Scanning Microscope
Deep optical sectioning of fluorescently labeled samples with SIM photoactivation

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Fluorescence

Zeiss Axiovert 200M Fluorescence
Imaging of samples labeled with fluorescent indicators

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Fluorescence

Zeiss Axiovert 200M Fluorescence
Imaging of samples labeled with fluorescent indicators

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Confocal

Olympus FV3000 Confocal Microscope
Optical sectioning of samples labeled with fluorescent indicators. Equipped with a resonant scanner for fast optical sectioning

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Confocal

Zeiss LSM 710 Confocal
Optical sectioning of samples labeled with fluorescent indicators

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Fluorescence

Zeiss Lumar Stereo Fluorescence
Imaging of samples labeled with fluorescent indicators

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Microscope

Nikon Eclipse TE200 Inverted Microscope
Transgenics and gene targeting microinjection microscope

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Microscope

Nikon Eclipse TS100 (cell culture scope)
Transgenics and gene targeting cell culture scope

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Microscope

Nikon SMZ1500 Zoom Stereomicroscopes
Transgenics and gene targeting dissecting microscopes (2 units)

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Microscope

Nikon SMZ800 Zoom Stereomicroscopes
Transgenics and gene targeting surgical microscope

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Electron

Thermo Apreo VS Scanning Electron Microscope (SEM) for serial block-face imaging
Equipped for standard scanning electron microscopy as well as serial-block face imaging. The automated system is capable of imaging large z-stacks at isotropic 10x10x10 nm resolution. The series of images can be processed for 3D reconstruction of cells and tissues, with sufficient resolution to identify small vesicles, organelles and neural connections.

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Electron

Philips 410 Transmission Electron Microscope (TEM)
Transmission electron microscopy with Advanced Microscopy Techniques (AMT) Camera Accessory

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microtome

Reichert Ultramicrotome
Ultrathin sectioning for light microscopy and transmission electron microscopy

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microtome Diamond Knife Set

Diatome DKS
Used on Reichert microtome to cut ultrathin sections for TEM

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Sample Preparation - Sputter Coater System

Emitech K550
Covers an EM specimen with a thin layer of conducting material

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Training and Technical Assistance - Bioimaging

Service
Service to provide Bioimaging technical assistance and training

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Imaging System - Gel Imager

LI-COR Odyssey Clx IR (Infrared) Imaging System
Western blot analysis, EMSA, protein arrays, In-Cell Western Assays, On-Cell Westerns, in vivo imaging, Coomassie gel documentation, DNA gel documentation, and tissue section analysis.

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Fluorescence

Nikon Ti2-E Fluorescence Microscope
Motorized fluorescence microscope with Perfect Focus System and software for high-content screening and 2D/3D deconvolution.

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microtome

Leica EM UC7 Ultramicrotome
Biological TEM and SBF prep

Molecular Pathology Core - Brown

Contact: David Silverberg

Microscope

Nikon Eclipse 50i light microscope
Collaborative analyses of histological slides and digital imaging capability

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Confocal

Zeiss LSM 800 Confocal
Optical sectioning of samples labeled with fluorescent indicators

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Imager and Microplate Reader

BioTek Cytation 5 Cell Imaging Multi-Mode Reader
UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence. Cell migration and invasion assays, Live cell imaging, Fluorescence cell imaging (DAPI & GFP), Multi-mode reader applications, Immunofluorescence, Phenotypic assays, Histology

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Fluorescence

Nikon Ti2-E Fluorescence Microscope for high-content imaging
The Nikon Ti2-E fluorecence microscope is a high-content imaging system, based on an inverted microscope and equipped for imaging standard slides, culture dishes, and microplates (e.g. 96-well plates). The microscope includes 'Perfect Focus' for autofocus applications, a Photometrics Prime 95B sCMOS camera for imaging fluorescence, a 16 megapixel Nikon DS-Ri2 color camera for imaging histology slides, a motorized stage and NIS-Elements High Content (HC) software for multiwell plate acquisition.

Electron Microscopy Facility

Contact: Anthony McCormick

Microscope - Focused Ion Beam Electron (FIB)

Thermo/FEI Helios Dual Beam Focused Ion Beam Electron Microscope (FIB) with an Omniprobe nanomanipulator and autoTEM sample preparation
The FIB is fully equipped for (near) simultaneous ion/electron beam imaging and patterning of specimens. A Pt metal deposition source is available for ion (or electron) beam assisted deposition of conducting lines. A second source is available to enhance the carbon removal rate. An Omniprobe AutoProbe 200.2 allows the physical manipulation of samples with nanometer precision and is used along with Pt metal deposition and standard FIB trenching to allow the selection and removal of electron transparent TEM samples from specific microstructural features. A NPGS pattern generation system (plus beam blanker and external scan interface) controls the electron beam for high resolution, interlaced pattern generation used in the FIB fabrication of nanostructures. Three dimensional crystallographic data can be generated from specimens using the fully automated EBSD system (Oxford HKL&EBS-3). The microscope is also equipped with an EDS detector for elemental analysis. An electron flood gun can be used with the ion beam to image/etch nonconductive samples. A low temperature holder is available for beam sensitive samples.

Electron Microscopy Facility

Contact: Anthony McCormick

Microscope - Scanning Electron (SEM)

LEO 1530 High Resolution Scanning Electron Microscope (HRSEM)
The LEO 1530 VP ultra-high resolution field emitter SEM that allows for a resolution of 1 nm at a voltage of 20 kV in high vacuum and 2 nm at 30 kV in the variable pressure mode. It is fully equipped with EDS for chemical mapping and includes a Debbem tensile test stage 5kn. The instrument is equipped with Nabity pattern generating software a high speed beam blanker and is set-up for high resolution electron-beam lithography. The LEO 1530 VP is capable of a resolution of 2.1 nm at very low electron energies (1 kV) which is of great use for beam-sensitive materials like polymers and insulating surfaces. Also very useful for insulating samples is the variable operating pressure mode which allows insulating materials to be imaged without coating the surface.

Electron Microscopy Facility

Contact: Anthony McCormick

Microscope - Transmission Electron (TEM)

FEI CM20 TEM
The FEI CM20 is available for applications that require high tilt, moderate resolution (0.23 nm). This 200 kV analytical TEM allows the large specimen tilts needed for dislocation characterization and weak-beam imaging applications. It is equipped with a low background double tilt holder and a liquid nitrogen temperature holder. Compositional analysis is performed on this instrument using energy dispersive x-ray spectroscopy. Images are recorded using a large field of view, side mounted, digital image acquisition system.

Electron Microscopy Facility

Contact: Anthony McCormick

Microscope - Scanning Transmission Electron Microscope -S(TEM)

JEOL 2100F - S (TEM)
The 2100F is a 200 kV, field emission source, high-resolution/analytical S(TEM) capable of 0.10 nm lattice resolution. It is primarily used for obtaining lattice images or when chemical or crystallographic information is required from laterally small areas (1-10 nm). The instrument is equipped with an x-ray spectrometer capable of light element detection, a Gatan image filter (GIF) for element and phase analyses and enegy filtered imaging, a high tilt holder for electron tomography and a high-resolution CCD camera system for digital image acquisition and processing. A low background double-tilt holder for chemical analysis by EDS, a standard double tilt holder, a heating holder capable of 1000C, and a heating straining holder are available. Probes as small as 1 nm in diameter are accessible for micro-diffraction experiments. STEM mode for EDS line and area scans, bright and dark field STEM detectors, and high angle annular dark field is capable in STEM mode.

Electron Microscopy Facility

Contact: Anthony McCormick

Spectrometer - ThermoElectron K-Alpha XPS

Thermo/FEI K-Alpha X-Ray Photoelectron Spectrometer
This equipment is used to study the surface composition of materials using photoelectrons generated by 30 kV monochromated Aluminum K-Alpha x-rays hitting the sample. It is equipped with an Argon sputter gun for surface cleaning and depth profiling. There is a tilt and rotate holder. There is a transfer holder so samples can be transferred to the XPS with exposure to atmosphere.

Electron Microscopy Facility

Contact: Anthony McCormick

Microscope - Quattro S-E(SEM)

Thermo/FEI Quattro S-E(SEM)
The Quattro is an environmental SEM which means that the sample chamber can be set to a (relatively) high pressure for water containing samples.  This SEM has EDS (X-ray detection) and EBSD (electron backscatter). The Quattro S is a field emission scanning electron microscope capable of generating and collecting all available information from any type of sample material. It provides the most versatile high-resolution low-vacuum FEG SEM with extended low-vacuum capabilities and the most versatile high resolution SEM for characterization, prototyping and in situ analysis. The features include three vacuum modes enabling investigation of conductive, non-conductive and high-vacuum incompatible materials such as High-vacuum mode (<6*10-4 Pa) for imaging and microanalysis of conductive and/or conventionally prepared specimens; Low-vacuum mode (10 to 130 Pa) for imaging and microanalysis of non-conductive specimens without preparation; and ESEM™ mode (10 to 4000 Pa) for high-vacuum incompatible specimens which are impossible to investigate with traditional EM methods. The system is equipped with a 5-axes motorized x-y-z-tilt-rotate stage,for Sample navigation.

Electron Microscopy Facility

Contact: Anthony McCormick

Sample Preparation

Electron Microscope Facility Sample Preperation Area
Tools available in the EMF sample preparation area include a jet polisher, polishing benches, dimpler and high and low speed diamond saws.The sample prep area has a carbon thread evaporator and Gold/Palladium sputter coater for making conductive coatings on SEM samples. There is an ion mill (PIPS) for making TEM samples. There is also a plasma cleaner for TEM sample holders and SEM samples.

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Confocal

Zeiss LSM 880 Confocal
Optical sectioning of samples labeled with fluorescent indicators

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Microplate Reader

BioTek Synergy H1 Hybrid Multimode (H1MM) Microplate Reader
UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence. Cell based assays, Biomarker assays, Micro-volume analysis of nucleic acid and protein, Kinetic assays.

Behavior and Neuroimaging Core

Contact: Michael Worden

Training and Technical Assistance - Support

Clinical Research Resources, Behavior and Neuroimaging
The mission of the Behavior and Neuroimaging Core (BNC) is to provide a coherent set of resources that will facilitate the implementation of each of the COBRE Project Leader’s research aims. The BNC provides ongoing support, training, assistance and advice to COBRE project leaders in the practical aspects of data collection, data management and data processing across a wide variety of neuroscience related methodologies. The BNC also serves as a resource to the broader neuroscience community at Brown and its affiliated hospitals and the broader Rhode Island academic community by providing formal and informal training, accessible data processing pipelines, and documentation of these and related resources. The support provided by the BNC is distinct from but complementary to services provided by the Design and Analysis Core (DAC). Whereas the DAC is focused primarily on study design, analytical modeling, and techniques for inference, the focus of the BNC is on practical aspects of research conduct such as efficient and high-quality data acquisition, implementation and deployment of standard and newly developed tools for analysis of large neuroimaging datasets, and lowering barriers to the use of such tools through direct assistance, training and documentation. Because the missions of the BNC and DAC are highly complementary, the effectiveness of each core is strengthened by collaborative relationships between them. The analytical techniques developed by the DAC in partnership with the Project Leaders are predicated upon robust high-quality data. Similarly, realization of study design principles requires practical expertise with the tools necessary to implement those principles. The BNC and DAC will share a full-time staff member with expertise in research design, statistical modeling, data management and high-performance computing.

Behavior and Neuroimaging Core

Contact: Michael Worden

Training and Technical Assistance - Facilitate Experimental Implementations

Clinical Research Resources, Behavior and Neuroimaging
Control experiments, Eye tracking, EEG guidance

Behavior and Neuroimaging Core

Contact: Michael Worden

Training and Technical Assistance - MRI Assistance

Clinical Research Resources, Behavior and Neuroimaging
Design of experiments, Analysis pipelines, EEG in the MRI scanner, Timing verification

Behavior and Neuroimaging Core

Contact: Michael Worden

Data Storage - Generalized Solutions

Clinical Research Resources, Behavior and Neuroimaging
xNAT database, Containers for data presentation, Beyond the desktop with VMs

Behavior and Neuroimaging Core

Contact: Michael Worden

Training and Technical Assistance - High Performance Computing (HPC)

Clinical Research Resources, Behavior and Neuroimaging
Assistance with High Performance Computing (HPC)

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Design - Experimental Design

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Multilevel and Hierarchical Modeling

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Machine Learning

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Feature Extraction

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Effective and Functional Connectivity

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Spatial-Temporal Modeling

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Time Series Modeling

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

General Linear Model (GLM) and Linear Model (LM)

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Analysis of Variance (ANOVA)

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Regression for High Dimensional Data

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Analysis - Network Analysis

Clinical Research Resources, Behavior and Neuroimaging

Design and Analysis Core

Contact: COBRE_CNSF@brown.edu

Causal Interference

Clinical Research Resources, Behavior and Neuroimaging

In Vivo Optical Imaging Core (Legorreta Cancer Center at Brown University)

Contact: Arunasalam Navaraj, PhD

Training and Technical Assistance

Service
Advise investigators with experimental design for in vivo imaging applications, provide access to instrumentation and training. Assist investigators with in vivo mouse, organ or cellular imaging, probe selection, antibody labeling, image analysis and presentation. Provide support for grant submissions.

X-ray Reconstruction of Moving Morphology Facility (XROMM)

Contact: Beth Brainerd, PhD

Imaging System - MicroComputed Tomography (uCT) Scanner

Bruker BioSpin
SkyScan 1276 in vivo microCT scanner for small animals (mouse to rat size)

Leduc Bioimaging Facility

Contact: Robbert Creton, PhD

Microscope - Slide Scanner

Olympus VS200
Automated slide scanner for imaging fluorescence and brightfield (e.g. H&E slides).

Bryant University
FacilityInstrument/Service/Resource Unit
Bryant Unistructure Science Spaces

Contact: Christopher Reid

Sample Preparation - Sputter Coater System

Denton Vacuum Desk V gold sputter coater and carbon coater
Coat non-conducting samples with gold or carbon for use on the SEM

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Microscope

Zeiss Primo Star with AxioCam
Recordable imaging

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Microscope

Zeiss Axiovert 40CFL Inverted Microscope
Recordable inverted microscopy

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Microscope

Zeiss A1 AXIO Polarized Light Microscope and Q imaging RETIGA 400R Imager
Recordable polarized light imaging

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Microscope - Electron

JEOL JSM 6010LA Scanning Electron Microscope (SEM)
Scanning electron microscope with EDS

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Sample Preparation - Critical Point Dryer

Tousimis Sandri-PVT-3D Critical Point Dryer (CPD)
Maintain structural integrity for soft tissue use of the SEM

Care New England - Women and Infants Hospital
FacilityInstrument/Service/Resource Unit
Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope

Leica MZ FLIII Stereo Fluorescent dissection microscope
Dissection microscope with Leica color camera DC300F.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope

Nikon 80i Upright Fluorescence Microscope
Upright microscope with color CCD camera Spot Insight 2

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope

Nikon TE2000E Inverted fluorescence,
A live cell imaging microscope, with cooled CCD camera Roper CoolSnap HQ

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope

Zeiss AxioImager M2 Upright Microscope,
Upright microscope with color CCD camera AxioCam MRC.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Centrifuge - Ultra

Beckman Coulter Optima XPN-80 Ultracentrifuge
SW-32.1Ti. SW-41Ti. TY-70.1Ti, TY70Ti rotors

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microscope - Spinning disk

Andor CSU-W1 spinning disk confocal system
The Spinning disk confocal microscope is a Nikon Ti-E (inverted) with Perfect Focus and motorized stage, with an Andor Zyla 4.2 plus SCMOS camera, an Andor CSU-W1 spinning disk with 405, 488 and 561 nm laser lines, as well as a SpectraX LED widefield light source and controlled by NIS-Elements software. This system is suitable for fast confocal imaging and live cell imaging, with low phototoxicity and long term focus stability. A stage incubator with CO2 and temperature control is available for maintenance of physiological conditions during  live cell imaging.

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Imaging Core

Zeiss LSM 700 confocal, Zeiss Axioplan 2 optical, Zeiss Axiovert 200M optical, IVIS Model 100
The Imaging Core facility provides technical and logistical access for fixed and live cell fluorescence imaging via visual and digital fluorescent microscopes. This core also offers the ability to visualize fluorescent and bioluminescent markers in live animals via an IVIS imager.

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Luminometer

Digene DML 2000 luminometer
The DML 2000 instrument is a luminometer that automates amplified chemiluminescent signal detection and results reporting for Hybrid Capture 2 (HC2) assays,

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Imaging System - Gel Imager

Bio-Rad Molecular Imager VersaDoc
Quantitative digital imaging system for single or multi-color images. Includes multiplexed samples (1-D or 2-D gels), chemiluminescent and chemifluorescent blots, and microplates.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Imaging System - Gel Imager

LI-COR Odyssey Classic Infared Imaging system
This near-infared fluorescent detector can be used for quantitative western blots, gel shift assays, coomassie stains, tissue section and small animal imaging.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Imaging System - Gel Imager

UVP GelCam 310 Bioimaging digital gel documentation system
High resolution 2.0 GelCam 310 CCD with manual zoom lens for fluorscent and colorimetric gel imaging. EtBr filter included.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Microscope

Nikon Eclipse TS-100F Inverted Microscope
This phase contrast microscope used for tissue culture is also equipped with FITC and TRITC filters to capture fluorescent images in SPOT imaging software.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Microscope

Nikon Eclipse 90i Upright Research Microscope
This microscope is equipped with two cameras (color and monochromatic) and is ideal for brightfield and/or epi-fluorescent images of whole tissues etc with 4x, 10x, 20x and 40x dry objectives. The filter cubes available are DAPI, FITC, and TRITC.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Imaging System

PerkinElmer FMT 4000 Fluorescence Tomography System.
The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. The system comes with four excitation laser channels (635, 680, 750, and 790 nm) and is useful for a range of applications including oncology, inflammation, and cardiovascular disease. It is ideal for researchers who are well-versed in 3D fluorescence tomography and require the widest range of in vivo applications and imaging agents.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Imaging System

Faxitorn Pre-clinical imaging system
Ultra-high resolution x-ray imaging is an important tool in investigating a variety of disease states. From metastatic cancer to arthritis and osteoporosis, small animal models are commonly used. Both in vivo and ex vivo planar imaging is used to screen, track, and evaluate structural changes in these studies. Cabinet x-ray systems allow researchers to take images directly in the vivarium to protect the integrity of the colony. These planar imaging systems are less expensive, subject animals to lower doses, and provide faster results than microCT systems.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Microscope

Olympus SZ61 Zoom Stereomicroscope
Greenough design with two optical paths inclined at an inward angle. Magnification range 0.67X to 4.5X; zoom ratio 6.7:1; FN 22. Working distance of 100mm; observation tube angle 45 degrees; right and left eyepiece tubes interlocked; interpupillary distance adjustment 50-76mm; forward positioned zoom adjustment knobs with zoom magnification graduations. With 0.5x cmount for documentation.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Imaging System

Xtreme back illuminated 4MP with x-ray for small animal imaging
High sensitivity luminescence, fluorescence, radioisotopic, and radiographic imaging for up to 5 mice at a time. Isofluarne and temperature controlled chamber for the mice.

Bioengineering Core

Contact: Braden Fleming, PhD

Imaging System - Camera

Qualisys Oqus 5-Series
The Oqus cameras are designed to capture accurate mocap data with very low latency and works with both passive and active markers.

Bioengineering Core

Contact: Braden Fleming, PhD

Microscope

Asylum Research MFP-3D-BIO
Atomic Force Microscope

Bioengineering Core

Contact: Braden Fleming, PhD

Microscope

Nikon TiU inverted microscope
Inverted Microscope

Lifespan-The Miriam Hospital
FacilityInstrument/Service/Resource Unit
Animal Models Core

Contact: Gerard Nau, MD

Imaging System - fluorescent and bioluminescent

PerkinElmer IVIS Lumina III in vivo imaging system
The IVIS Lumina III is capable of imaging both fluorescent and bioluminescent reporters. The system is equipped with up to 26 filter sets that can be used to image reporters that emit from green to near-infrared. Superior spectral unmixing can be achieved by Lumina III’s optional high resolution short cut off filters.

Providence College
FacilityInstrument/Service/Resource Unit
PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Imaging System - Camera

Fastec HiSpec1, Low-Light High-Speed Camera
Innovative Low-Light High-Speed Camera. Monochrome with 2GB Memory, C-Mount, includes ImageBLITZ Auto Trigger, Burst Trigger Mode, Multi- Sequence Record Mode (1280 x 1024 at 506fps) 2 Units

PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Microscope - Electron

Philips EM-300 Transmission Electron Microscope (TEM)
Transmission electron microscopy

PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Sample Preparation - Laboratory - Prep Lab

Electron Microscopy Prep Lab
Laboratory space for preparing samples for electron microscopy

PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Microscope - Electron

Amray-1000 Scanning Electron Microscope (SEM)
Scanning Electron Microscope equipped with EDEX for elemental analysis and a digital imaging system, a Zeiss Axiophot equipped for bright field, dark field, DIC and fluorescence microscopy with a digital imaging system

PC - Sowa Hall Labs

Contact: Charles Toth

Microscope

Zeiss LMS 700 Flexible Confocal Microscope
Performs fluorescence measurements, creates optical sections of samples and combines them into 3D image stacks.

Rhode Island College
FacilityInstrument/Service/Resource Unit
RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microscope

American Optical Series 10 Fluorescence Microstart
Microscopy course

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microscope

Nikon E600 Epifluorescence with DIC/Phase and digital camera
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microscope

Olympus CKS41 Inverted Microscope
Tissue culture general use

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microscope

Olympus Compound Light Microscope
General use

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microscope

Olympus FluoView 1000 Laser Scanning Confocal Microscope
Research and Microscopy course

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microscope

Olympus Inverted Epifluorescence Microscope with digital camera
Tissue culture/Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microscope

Zeiss SteREO discovery V8 Microscope with Digital Camera
Research

Rhode Island School of Design
FacilityInstrument/Service/Resource Unit
RISD Nature Lab

Contact: Jennifer Bissonnette

Microscope

Phenom G2Pro Scanning Electron Microscope (SEM)
Desktop Scanning Electron Microscope with ProSuite tiling and remote access software

RISD Nature Lab

Contact: Jennifer Bissonnette

Microscope

Olympus SZX16 Stereomicroscope
Light microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software

RISD Nature Lab

Contact: Jennifer Bissonnette

Microscope

Olympus IX51 Inverted Fluorescent/Brightfield Microscope
Fluorescence/brightfield microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software

RISD Nature Lab

Contact: Jennifer Bissonnette

Microscope

Olympus CH30 Upright Light Microscope
Upright light microscope with 5 MP Jenoptik digital camera, Canon Vixia HFS20 HD video camera, computer workstation, graphics and imaging software (2 units)

RISD Nature Lab

Contact: Jennifer Bissonnette

Microscope

Olympus SZ40 Stereomicroscope
Light microscope with 5 MP Jenoptik digital camera, computer workstation, graphics and imaging software

RISD Nature Lab

Contact: Jennifer Bissonnette

Microscope

Olympus SZ30 Stereomicroscope
Light microscope with LED illuminator (24 units)

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Marine Science Research Facility

Contact: Dawn Outram

Imaging System - Camera

Olympus EP50 Microscope Camera w/ HDMI Monitor
Captures Microscope video and still images (C-mount)

Marine Science Research Facility

Contact: Dawn Outram

Analyzer - Fluid Particle Counter and Imager

Fluid Imaging Technologies FlowCam
Imaging Particle Analysis: counts and records images of particles in liquid samples

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Imaging System - Gel Imager

LI-COR Odyssey IR (Infrared) Imaging System
IR gel imager

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Microplate Reader

Molecular Devices SpectraMax M2
Fluorescence/UV/VIS

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Microplate Reader - Luminometer

Promega GlowMax System
Chemiluminescence

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Microscope

Nikon Eclipse E600 Upright Microscope
Microscope

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Microscope

Nikon Eclipse Ti2 inverted confocal microscope
Confocal Microscope

Marine Science Research Facility

Contact: Dawn Outram

Microscope

Nikon inverted Microscope
Microscopy. Works with Olympus EP50 Camera

Marine Science Research Facility

Contact: Dawn Outram

Microscope

Olympus SZX16 Stereo Microscope
Microscopy. Works with Olympus EP50 Camera

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - X-ray

Zeiss Xradia Versa 610 with in situ tensile, compression and temperature stage
X-ray microscopy and tomography of samples up to 10 cm in diameter with resolution up to 500 nm

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - Confocal Raman Spectroscopy

WITec alpha 300R
Confocal imaging and chemical analysis by Raman spectroscopy up to 100x magnification, 3D chemical imaging, large area imaging, principal component analysis of chemical composition, upright and inverted mode, automated XY stage, 785 and 532 nm excitation lasers

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microtome

Sorvall MT2-B ultramicrotome
Preparation of biological tissue, cross sections and embedded samples for TEM.

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Sample Preparation - Sputter Coater System

Cressington 7002-8 sputter coater with film thickness monitor
Coat non-conducting samples with gold for use on the SEM, rotating/tilting stage for coating of large specimens.

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Spectrometer - Energy Dispersive X-Ray Fluorescence

Shimadzu EDX-8100
Energy dispersive X-ray fluorescence of powders, solids and liquids. Ambient pressure, vacuum and He atmosphere

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - Field Emission-Scanning Electron Microscope (FE-SEM)

Zeiss Gemini Sigma VP Field Emission-Scanning Electron Microscope (FE-SEM)
Field emission scanning electron microscope Zeiss Gemini Sigma VP, with cryoSEM (Gatan), energy dispersive X-ray spectroscopy (Oxford Instruments), variable pressure mode, backscattering detector, in lens detector and secondary electron detector

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - Scanning Transmission Electron

JEOL F200
Scanning transmission electron microscope with cryogenic capabilities, direct electron camera (Gatan K3), Energy dispersive X-ray spectroscopy (JEOL), electron energy loss spectroscopy (Gatan). Sub nanometer resolution, 80 and 200 kV operation, TEM, STEM and diffraction

Cell Analysis and Sorting Core

Contact: Alan Rothman, M.D., Research Professor

Microplate Reader

BioTek Cytation 3
Imaging plate reader; 5 colors (brightfield, GFP, RFP, DAPI, Cy5); 10x, 20x, 60x objectives

Cell Analysis and Sorting Core

Contact: Alan Rothman, M.D., Research Professor

Microscope

Life Technologies Evos FL, Fluorescence Microscope
Fluorescence microscope; 4 colors (GFP, RFP, DAPI, Cy5); 10x, 40x, 100x objectives

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - Transmission Electron Microscope

JEOL JEM-2100 LaB6 Transmission Electron Microscope (TEM)
Transmission electron microscope JEOL JEM 2100 with sub nanometer resolution, cryoTEM (Gatan) and energy dispersive X-ray spectroscopy (Oxford Instruments)

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - Fourier Transform Infrared Spectroscopy

Shimadzu AIM-9000 with Shimadzu IRTracer100
FTIR microscope and spectrometer, ATR, liquid and gas cell.

Marine Science Research Facility

Contact: Dawn Outram

Microscope

Nikon Eclipse Ni epifluorescence microscope
Epifluorescence and phase microscopy with digital camera system

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Imager - Biomolecular

Azure Sapphire Biomolecular Imager
The Azure Sapphire Biomolecular Imager is a laser scanning system has four lasers (488, 520, 658 and 784 nm) giving a wide range of excitation. The instrument supports long and short wavelength Near IR fluorescence, red/green/blue imaging, and chemiluminescent imaging. Multiple detectors are used depending on the excitation wavelength and application for maximum sensitivity. It can accommodate gels up to 25cm by 25 cm.

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - High Content Screening System

Perkin Elmer - Opera Phenix
High Content Screening System: Automated confocal fluorescence microscope designed for high-throughput 3D imaging of fluorescent samples in microplates, live-cell imaging, drug screening, spheroid imaging

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Sample Preparation - Critical Point Drier

Tousimis Sandri-PVT-3B
Critical point dryer (CPD) Maintain structural integrity for soft tissue use of the SEM.

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Microscope - Atomic Force

Shimadzu SPM-9700
Scanning probe microscope for atomic force microscopy, magnetic force microscopy, liquid cell analysis, Kelvin force microscopy, I/V curves, nanomechanical measurements

VA Providence Healthcare System
FacilityInstrument/Service/Resource Unit
IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Imaging System - Slide Scanner

Aperio ScanScope CS Digital Slide Scanner CS
Brightfield 5 slide scanner with two workstations with Aperio brightfield imaging analysis software.

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Imaging System - Slide Scanner

Aperio Scan Scope FL Fluorescent Digital Slide Scanner
5 slide scanner with Indica Labs fluorescence imaging analysis software.

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Imaging System - Echocardiograph

VisualSonics, Vevo 2100 Imaging System
A high-frequency, high-resolution digital imaging platform with linear array technology and Color Doppler Mode. The Vevo 2100 Imaging System enables in vivo visualization, assessment, and measurement of anatomical structures and hemodynamic function in longitudinal imaging studies for small animal and zebrafish phenotyping.

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Microscope

Nikon Ni-E upright research microscope
Capture both phase, DIC, brightfield and fluorescence images at high magnification with enhanced features such as Z-stack imaging and multi-channel

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Imaging system - Laser Doppler

Moor instruments, laser Doppler imaging system
Laser Doppler Imaging examines blood flow non-invasively. Used to examine blow flow in capillary beds in response to pulmonary hypertension, exercise, and/or ischemia/reperfusion.

Imaging/Studio Production

Brown University
FacilityInstrument/Service/Resource Unit
Scientific Illustration and Visual Design

Contact: Vinald Francis

Design - Illustration, Graphic Design, and Data Displays

Service
BioMedical Communications offers medical and scientific illustration, graphic design, and data displays for use in web, digital, and print media to faculty across the Division of Biology and Medicine.

Rhode Island School of Design
FacilityInstrument/Service/Resource Unit
RISD Media Resources

Contact: David Chandler

Imaging System - Audio|Visual

Kodak zi 10 Video Camera (8 units)
Portable HD pocket camcorder, batteries, adaptor cables, cases, accessories

RISD Media Resources

Contact: David Chandler

Imaging System - Audio|Visual

H4N ZOOM Audio Recorder (5 Units)
High performance portable digital audio recorder, batteries, adaptor cables, cases, accessories

RISD Media Resources

Contact: David Chandler

Imaging System - Audio|Visual

ZOOM Q3 Video Camera (7 Units)
Portable palm camcorder, batteries, adaptor cables, cases, accessories

RISD Media Resources

Contact: David Chandler

Imaging System - Audio|Visual

EPS-SonyPMWEX1R-01 (2 Units)
High performance HD CMOS solid state video camera, batteries, portable hard drive, adaptor cables, cases, studio lighting equipment, accessories

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
MakerspaceURI

Contact: makerspace@etal.uri.edu

Imaging System - 3D Scanner

EinScan Pro 2X

MakerspaceURI

Contact: makerspace@etal.uri.edu

Computer - Tablets

IPad 7th Gen (4), Microsoft Surface

MakerspaceURI

Contact: makerspace@etal.uri.edu

Imaging System - 3D Printer

Makerbot Replicator+ (2); Dremel 3D20 (9); TAZ Workhorse; Formlabs (2)

MakerspaceURI

Contact: makerspace@etal.uri.edu

Cutter - Vinyl

GCC Expert Pro Vinyl Cutter, Cameo Silhouette (2)

MakerspaceURI

Contact: makerspace@etal.uri.edu

Vacuum Former

Vaquform DT2

MakerspaceURI

Contact: makerspace@etal.uri.edu

Imaging System - Audio|Visual - VR Headsets

HTC Vive Pro (3); Oculus Quest 2 (2)

MakerspaceURI

Contact: makerspace@etal.uri.edu

Imaging System - Camera

Sony Alpha a6400 Mirrorless Digital Camera (with a tripod and accessories)

Informatics

Brown University
FacilityInstrument/Service/Resource Unit
Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Analysis - Data Analysis

Service
The core provides assistance in experimental design and data processing pipelines for high-throughput datasets generated in individual projects, particularly for DNA/RNA sequencing data.

Biomedical Informatics Core

Contact: Neil Sarkar, PhD

Biomedical Informatics Services

Clinical Research Resources, Biomedical Informatics
Data Requests Storage and management Processing and analysis Submission and dissemination Software and Applications Requests Development REDCap Studies/Projects Project setup Education 5x5 Clinical Informatics elective Biomedical Informatics Learning Series Grant Support

Biomedical Informatics Core

Contact: Neil Sarkar, PhD

Biomedical Informatics Resources

Clinical Research Resources, Biomedical Informatics
Cohort Identification i2b2 tranSMART [local] i2b2/SHRINE [regional] TriNetX [national] Data Collection and Management Statewide REDCap instance Wrike and SPARCRequest Data Access and Use Unified Data Sharing & Analysis (URSA) Initiative URSA stronghold URSA data requests URSA governance URSA computational tools Subject Recruitment Research Networking and Resources

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Analysis - Standardized Data

Service
Develop/Implement Bioinformatic Pipelines; GATK whole exome, Cut and run. Develop/Implement Standardized QC for Workflows. Experimental Design Support; Power Analysis for Microbiome and RNAseq. Exploratory Data Analysis; RNAseq, scRNA seq.

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Tooling

Software - R-Qckit
A comprehensive quality control R package for Next Generation Sequencing FASTQ data.

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Tooling

Software - RSeqAn
Wrappers for the SeqAn library for use in R with Rcpp

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Tooling

Software - Bioflows
A bioinformatics workflow engine that streamlines the most common analysis pipelines. Key features include: 1) Provision of standardized workflows 2) A module for automating SRA downloads and 3) External tools are made available as CONDA packages along with the tool.

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Tooling

Software - Scripts
Access Genbank, BioCookBook.jl

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Tooling

Containerization with Docker - NMRDock
NMRdock is a Docker container image for processing raw NMR time domain data into frequency domain spectra and analyzing the spectra. The image includes NMRPipe and NMRFAM-Sparky for processing and analysis, respectively. NMRdock can be installed on any operating system (OSX, Windows, or Linux) and has the full functionality of both NMRPipe and NMRFAM-Sparky. For guides on processing BioNMR data in NMRdock, please access our Walkthrough Section

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Tooling

Software- Ingenuity Pathway Analysis
The CBC provides access to the Ingenuity Pathway Analysis web server at Brown University.

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Analysis - Data Analysis

Service
The CBC now allows for a very restricted schedule of Fee-For-Service project.

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Data Management

CCV - RefChef
RefChef is a reference management tool used to: (1) document the exact steps undertaken in the retrieval of genomic references; (2) maintain the associated metadata; (3) provide a mechanism for automatically reproducing retrieval and creation of an exact copy of genomic references.

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Training and Support

Service
Workshops

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Training and Support

Service - Consulting
The Core provides two distinct complimentary services to all researchers at Brown. Appointment Based, A team of experienced computational biologists and biostatisticians are on-hand to help investigators design experiments. Weekly Consulting Sessions, The Core offers two hours *walk-in Consulting* sessions for all researchers to discuss any immediate issues in data analysis including trouble-shooting code, help with statistical analysis and discussion of options for bioinformatic analysis.

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Training and Support

Service -Talent Development
Student worker/interns, Guidance and mentoring

Computational Biology Core (CBC)

Contact: Ashok Ragavendran

Training and Support

Service - Outreach
CBC hosts workshops, publishes tutorials on computing tools used by bioinformaticians, and provides analysis support to the Brown community.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Rhode Island INBRE Molecular Informatics Core (MIC)

Contact: Christopher Hemme

Bioinformatics Analysis

Service - Bioinformatics
We provide bioinformatics consultation and services to the Rhode Island INBRE community and to the general scientific community of Rhode Island. In addition to traditional bioinformatic services, our Core is expanding to 3D/VR/AR visualization services in conjunction with the URI 3D Visualization Laboratory. We are currently developing 3D/VR visualization apps for a variety of platforms including smartphones, Vive/SteamVR, and others. We also have access to the 3D printer at the URI 3D Visualization Core for printing of marcomolecules at a reasonable price.

Marine Science

Providence College
FacilityInstrument/Service/Resource Unit
PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Aquatic System

Aquatic Habitats Glass Tank System and Life Support Controller
Glass tank system and life support controller with low water level protection (18-10 gallon tanks)

Rhode Island College
FacilityInstrument/Service/Resource Unit
RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Aquatic System - Wet Lab / Aquarium room

Aquaria and related equipment
Research

Rhode Island School of Design
FacilityInstrument/Service/Resource Unit
RISD Nature Lab

Contact: Jennifer Bissonnette

Aquatic System

Marine Ecological Habitats Closed-System Aquarium
560 L closed-system recirculating marine holding tanks with temperature control (2 units)

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Marine Science Research Facility

Contact: Dawn Outram

Analyzer - Dissolved Gas

Bay Instruments Membrane Inlet Mass Spectrometer- Dissolved Gas Analyzer
Mass Spectrometer: Quantifies dissolved gases

Marine Science Research Facility

Contact: Dawn Outram

Analyzer - Multiparameter Water Analyzer

YSI Professional Plus Hand Held Multiparameter Water Meter
Measures temperature, salinity, dissolved oxygen (DO), and pH

Marine Science Research Facility

Contact: Dawn Outram

Analyzer - Nutrient

Lachat QuickChem 8500 Flow Injection Nutrient Auto Analyzer
Measures dissolved nutrients in water, Ammonia, Phosphate, Nitrite, Nitrate, and Silicate

Marine Science Research Facility

Contact: Dawn Outram

Fluorometer

Satlantic Fluorescence Induction Relaxation Fluorometer (FIRE)
Measures variable fluorescence in phytoplankton

Marine Science Research Facility

Contact: Dawn Outram

Incubator

Percival Incubator/Growth Chamber
Temperature and light controlled incubator for environmental applications

Marine Science Research Facility

Contact: Dawn Outram

Radiometer

Biospherical Instruments Quantum Scalar Laboratory (QSL) Radiometer - PAR Light Meter
Measures Photosynthetically Active Radiation (PAR)

Marine Science Research Facility

Contact: Dawn Outram

Spectrometer

Ocean Optics Jaz Spectrometer
Optical sensing instrumentation that measures light wavelengths. Its unique features and expandable platform makes it uniquely suited for field applications, remote sensing, process flow and quality assurance.

Marine Science Research Facility

Contact: Dawn Outram

Vacuum Manifold

Vacuum Filter Manifold
Allows for filtration of 5 ports simultaneously, 25 and 47 mm filter cups available

URI Sources, Transport, Exposure & Effects of PFAS (STEEP)

Contact: Simon Vojta

Mass Spectrometer

SCIEX X500R QTOF PLATFORM coupled to an EXION LC AC SYSTEM
A tandem (MS/MS) mass spectrometer combining a quadrupole and a time-of-flight analyzer allows collecting high-resolution MS and MRM spectra. The instrument is suitable for both quantitative analysis as well as non-targeted approach and operates under SCIEX OS software. The collected data are evaluated using an independent processing station (SCIEX Alpha Workstation 2020) equipped with SCIEX OS-Q software

Marine Science Research Facility

Contact: Dawn Outram

Aquatic Culture - Algae and Live Feed Room

Various manufacturers
K-walls, small rearing tanks for live feed, flowing seawater and freshwater

Marine Science Research Facility

Contact: Dawn Outram

Aquatic Culture - Phytoplankton Culture Wheels

Various manufacturers
Motorized and water driven, clear plexiglass, ambient and experimental temperature control, can accommodate culture bottles of differing sizes (1-3L)

Marine Science Research Facility

Contact: Dawn Outram

Aquatic System - Dechlorination System - Freshwater

Various manufacturers
2 Freshwater dechlorination tanks

Marine Science Research Facility

Contact: Dawn Outram

Workstation - Environmental Chamber

EnvironAir Environmental Chamber
100 sq ft Temperature control, Two range 4-24 C, Two range -4-24 C (to simulate polar conditions), On generator back up and emergency monitoring systems. (4 Units)

Marine Science Research Facility

Contact: Dawn Outram

Aquatic System - Flowing Seawater System

Various manufacturers
Raw-Ambient temperature and Filtered- Chilled, Heated, Ambient. UV treated, air supply, emergency monitoring systems

Marine Science Research Facility

Contact: Dawn Outram

Biospecimen Banking - Freezer - Walk-in

-20 C Walk-In Freezer
185 sq ft Long term storage, On generator back up and emergency monitoring systems

Marine Science Research Facility

Contact: Dawn Outram

Photoperiod controller

Various manufacturers
Wattstopper controller(Blount), Various individual timers

Marine Science Research Facility

Contact: Dawn Outram

Pier Access

Access to Graduate School of Oceanography pier
Access to pier for deployment, collection, testing. Water depths 18-15 feet to intertidal zone

Marine Science Research Facility

Contact: Dawn Outram

Aquatic System - Laminar Flow Tank

Laminar Flow Tank
1000 gal, Seawater or Freshwater, Multiple speeds with precision control. Experimental chamber visable from 5 sides

Marine Science Research Facility

Contact: Dawn Outram

Aquatic System - Mesocosm Tank

Various manufacturers
10, 5 ft deep outdoor mesocosms, with available raw ambient seawater flow

Marine Science Research Facility

Contact: Dawn Outram

Worksation - Marine General Wet Lab

Various manufacturers
3 Buildings, 7,000 sq ft indoor, and nearly unlimited outdoor space, Multiple insulated tank sizes, various sized aquaria, possible to perform simultaneous replicates

Marine Science Research Facility

Contact: Dawn Outram

Workstation - Marine Pathology and Transgenics Laboratory and Systems

Various manufacturers
Ozone treated effluent and separate effluent drain

Marine Science Research Facility

Contact: Dawn Outram

Fluorometer

Turner Designs Trilogy
Measures extracted or in vivo chlorophyll fluorescence of samples, Field-portable

Marine Science Research Facility

Contact: Dawn Outram

Sensor - Oxygen Sensor

PreSens
Water phase analysis

Microbiology

Brown University
FacilityInstrument/Service/Resource Unit
Single Cell Technologies Core (Legorreta Cancer Center at Brown University)

Contact: Paul Bertone, PhD

Training and Technical Assistance

Service
Advise investigators with experimental design for single cell analysis including implementation of technical plans as well as analysis of results. Advise on single cell genomics, RNA-seq, ChIP-seq and bioinformatic analysis. Provide support for grant submissions.

Bryant University
FacilityInstrument/Service/Resource Unit
Bryant Unistructure Science Spaces

Contact: Christopher Reid

Biological Safety Cabinet

LABGARD ES class II, type A2 Biological Safety Cabinet
Maintain sterility and contain infectious work

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Workstation - Anaerobic Chamber

Microbiology International Whitley DG250 Anaerobic Workstation
Simulate anoxic environments for anaerobic work

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Workstation - Anaerobic Chamber

MBRAUN Labstar Anaerobic Glovebox Workstation
simulate anoxic environments for anaerobic work

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Microplate Reader - Fluorescence

Fluoroskan Ascent
Measures sample fluorescence Excitation wavelengths 320-700 nm, emission 360-700 nm

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

PCR Thermal Cycler

Illumina Eco real-time PCR system
The Eco Real-Time PCR System offers life science researchers a full-featured real-time PCR system at an attractive price. Its features include:  Four-color multiplexing  High Resolution Melt (HRM)  Fast PCR cycling: 40-cycle PCR in 40 minutes  User-friendly, MIQE-compliant software.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Sample Preparation - Automated pipettor

Opentrons OT-2
Automated sample preparation platform for staining well plates

VA Providence Healthcare System
FacilityInstrument/Service/Resource Unit
IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Imager and Microplate Reader

BioTek Cytation 5 microplate reader
Imaging plate reader; 5 colors (brightfield, GFP, RFP, DAPI, Cy5) 4x, 10x, 20x objectives.

Molecular & Cell Biology

Brown University
FacilityInstrument/Service/Resource Unit
Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Cell Counter

Life Technologies Automated Countess Cell Counter
Measure cell count and viability (live, dead, and total cells) using the standard trypan blue technique.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Microarray Platform

Affymetrix Gene Chip Instrument System
A fully integrated platform for Affymetrix microarrays

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Microarray Scanner

Molecular Devices GenePix Scanner 4000B
Two color microarray scanner

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Electroporation System

ThermoFisher Scientific Neon Transfection System
Nucleic acid and protein electroporation

Lentivirus Construct Core (Legorreta Cancer Center at Brown University)

Contact: Olin Liang, Ph.D.

Lentivirus-mediated Stable Gene Over-expression in Cells

Service

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Spectrophotometer

ThermoFisher Scientific NanoDrop Lite
Measures nucleic acid and protein concentration

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Bioanalyzer

Agilent Bioanalyzer 2100
Microfluidics-based platform for sizing, quantification and quality control of DNA, RNA.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Analyzer - Fragment

Advanced Analytical, Fragment Analyzer
Capillary Electrophoresis - Analyze DNA fragments for Next-Gen Sequencing, genotyping, checking RNA quality and quantity, and working with microsatellite simple sequence repeats (SSRs).

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Centrifuge

Sorvall Legend T Benchtop
Low to medium speed centrifugation

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Centrifuge - Ultra

Beckman Coulter Optima Max UltraCentrifuge
High speed centrifugation with MLA130, TLA110 & TLA100 Rotors

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Disrupter

Covaris S220 High Performance Ultrasonicator
DNA, RNA, and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Imager and Microplate Reader

BioTek Cytation 5 Cell Imaging Multi-Mode Reader
UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence. Cell migration and invasion assays, Live cell imaging, Fluorescence cell imaging (DAPI & GFP), Multi-mode reader applications, Immunofluorescence, Phenotypic assays, Histology

Drosophila Media Facility

Contact: Katherine Patenaude

Drosophila Media Preparation

Service
The Drosophila Media Facility is dedicated to providing investigators with high quality media for Drosophila research. In the centralized kitchen, a standard cornmeal, sucrose, yeast medium is prepared and dispensed into different sized culture vessels. Media is prepared according to a strict protocol that ensures consistency in diet and the absence of any bacterial, fungal or insect contamination. Researchers using glass vials return them to the facility where they are autoclaved, washed, and filled again. This centralized kitchen is equipped with a food-service quality Cleveland Range Kettle MKET-12-T. Media is pumped into trays of vials or plastic bottles using a Gilson Fly Food Dispenser. Used glass vials are returned to the facility where they are sterilized in a Steris autoclave and washed in a Northwestern Systems G403 electric heat glassware washer.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

PCR Thermal Cycler - Droplet Digital

Bio-Rad QX200 Droplet Digital (ddPCR) PCR System
Provides absolute quantification of target DNA or RNA molecules for EvaGreen or probe-based digital PCR applications.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

PCR Thermal Cycler

Applied Biosystems ViiA 7 Real-Time PCR System
Medium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

PCR Thermal Cycler

Applied Biosystems ViiA 7 Real-Time PCR System
Medium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Spectrophotometer

Thermo Scientific Nanodrop One
A microvolume spectrophotometer for measuring DNA and RNA.

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Technical Assistance - Affmetrix Microarray

Service
Service to provide Affymetrix gene expression array service

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Technical Assistance - NGS Library Quality Control

Service
Analysis of library size distribution and qPCR quantification

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Analyzer - nCounter Systems

NanoString - nCounter Sprint Profiler
Molecular barcoding technology for RNA, DNA, and protein profiling applications. Digitally examine multiple pathways in a single tube in an extraction-free workflow. Included nSolver Analysis Software. Compatible with FFPE tissue. Highly multiplexed analysis of many functional pathways such as among others cancer, inflammation, cell death and custom designed expression analysis. Operated as fee for service.

Lentivirus Construct Core (Legorreta Cancer Center at Brown University)

Contact: Olin Liang, Ph.D.

Lentivirus-mediated CRISPR/Cas9 Gene Knock-out in Cells

Service

Lentivirus Construct Core (Legorreta Cancer Center at Brown University)

Contact: Olin Liang, Ph.D.

Site-directed Mutagenesis

Service

Lentivirus Construct Core (Legorreta Cancer Center at Brown University)

Contact: Olin Liang, Ph.D.

Virus Packaging

Service

Genomics Facility - Brown

Contact: Christoph Schorl, PhD

Microplate Reader

BioTek Synergy H1 Hybrid Multimode (H1MM) Microplate Reader
UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence. Cell based assays, Biomarker assays, Micro-volume analysis of nucleic acid and protein, Kinetic assays.

Drug Discovery Core (Legorreta Cancer Center at Brown University)

Contact: Shengliang Zhang, PhD

Training and Technical Assistance

Service
Advise interested investigators on cancer drug screens, cell-based assay development, assay optimization, and use of various chemical libraries/FDA-approved drugs to support research in the area of drug discovery and development. Advise on target validation, and interface with medicinal chemistry. Provide technical support for screening implementation, library plating, high-throughput robotic screening, and advice on prioritization of hits. Provide support for grant submissions.

Translational Oncology Core (Legorreta Cancer Center at Brown University)

Contact: Attila Seyhan, PhD

Training and Technical Assistance

Service
Advise investigators on study design leading to translational clinical protocols. For prioritized studies, provide assistance with clinical protocol preparation as well as NIH, Industry or Foundation grant submissions to secure funding for the research.

CyTOF Core (Legorreta Cancer Center at Brown University)

Contact: Patrycja Dubielecka-Szczerba, PhD

Training and Technical Assistance

Service
Advise investigators with experimental design, implementation and data analysis. Provide support for grant submissions.

Organic Synthesis Core (Legorreta Cancer Center at Brown University)

Contact: Xiaobing Tian, PhD

Training and Technical Assistance

Service
Assist investigators with experimental plans for drug synthesis for lead optimization. Facilitate organic synthesis efforts through interactions with the Department of Chemistry, Industry or other collaborations. Provide support for grant submissions.

Organoids Core (Legorreta Cancer Center at Brown University)

Contact: Lanlan Zhou, MD, PhD

Training and Technical Assistance

Service
Advise and assist investigators with the production of organoids to facilitate cancer biology, drug efficacy and toxicity evaluation of therapeutics towards tumor versus normal organoids that express different cancer gene mutants. Provide support for the growth and maintenance of organoid and spheroid cultures including passaging. Maintain a collection of established organoids that can be provided to investigators for research. Develop gene knockout and overexpression matched patient-derived organoids. Assist investigators with planning of drug screens working with the drug discovery capability. Provide support for grant submissions.

Bryant University
FacilityInstrument/Service/Resource Unit
Bryant Unistructure Science Spaces

Contact: Christopher Reid

PCR Thermal Cycler

Bio-Rad PCR Thermocycler C1000 Touch
DNA amplifier

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Spectrophotometer

Thermo Scientific AquaMate Plus
UV/Vis spectrophotometer for quantifying concentrations

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Spectrophotometer

Shimazdzu HPLC--equipped with UV/Vis and Evaporative light scattering detectors
UV/Vis spectrophotometer for quantifying concentrations

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Biospecimen Banking - Freezer

Thermo Scientific Isotemp Basic U86-13A41 minus 70 degree freezer
Long term storage of biological specimens

Bryant Unistructure Science Spaces

Contact: Christopher Reid

Sample Preparation - Freeze Dry System

Labconco FreeZone 4.5
Freeze dryer

Bryant Unistructure Science Spaces

Contact: Christopher Reid

PCR Thermal Cycler

Bio-Rad CFX96 touch RT-PCR
This real-time pcr instrument allows for up to 5-target multiplexing in sample volumes as small as 10ul. It also has a thermal gradient feature in a 96-well format.

Care New England - Women and Infants Hospital
FacilityInstrument/Service/Resource Unit
Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Imaging System - Gel Imager

Bio-Rad Chemidoc XRS
The ChemiDoc XRS+ system is based on CCD high-resolution, high-sensitivity detection technology and modular options to accommodate a wide range of samples and support multiple detection methods including fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence. The system is controlled by Image Lab software to optimize imager performance for fast, integrated, and automated image capture and analysis of various samples.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Imaging System - Gel Imager

Bio-Rad Molecular Imager FX system
Imager with 50 micron resolution and a 5 order of magnitude linear dynamic range for fluorescence and radioisotopic imaging. You can also image and accurately quantitate chemiluminescent samples.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Cell Sorter - Magnetic-Activated Cell Sorter (MACS)

Miltenyi AutoMACS Magnetic cell sorter
Automated cell sorter, for separating cell suspensions labeled with magnetic beads

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microplate Reader

Molecular Devices Spectramax Gemini EM Fluorescence Microplate Reader
Enables top and bottom reading of microplates over a greater range of fluorescence intensities all without the use of filters.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Microplate Reader

Perkin Elmer TopCount NXT Microplate Scintillation and Luminescence Counter
TopCount NXT analyzes two, six, or twelve samples at a time, and counts samples in 24-, 96-, and 384-well microplates, as well as microcentrifuge tubes. It can count gammas, betas, or luminescent samples.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

PCR Thermal Cycler

Applied Biosystems ABI 7500
96-well quantitative PCR

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Spectrophotometer

Bio-Rad SmartSpec
90-260 V, UV/visible benchtop spectrophotometer for nucleic acid and protein quantitation, wavelength range 200–800 nm, built-in thermal printer

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Spectrophotometer

Thermo Scientific NanoDrop 2000
A full spectral microvolume UV-Vis analysis spectrophotometer for measuring DNA, RNA, and protein.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Suspension Array System

Bio-Rad BioPlex 200
Detection and quantification of multiple analytes (proteins and peptides, or nucleic acids) in a single sample volume.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Analyzer - Nanoparticle counter

Malvern Nanosight NS300
Analysis of size distribution and concentration of nanoparticles from 10nm to 2000nm in diameter. A 532nm green laser also allows the detection of red fluorescent particles. A syringe pump allows sample analysis under constant flow, increasing reliability and reproducibility of data.

Molecular Biology and Imaging Core

Contact: Sunil Shaw, PhD

Single Cell Analysis for RNAseq

1Cell Bio InDrop
The InDrop enables single cell encapsulation, barcoading of cDNA, preparation of a sequencing librrary, and informatics.

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Molecular Core

Applied Biosystem PRISM 7000 Sequence Detection System, Bio-Rad ChemiDoc Molecular Imager, Bio-Rad CFX96 Touch Real-Time PCR Detection System
The molecular core offers the capability of performing PCR analysis, quantitative real-time PCR analysis, and digital gel documentation.

Community College of Rhode Island
FacilityInstrument/Service/Resource Unit
CCRI Biology Labs

Contact: David Vito

Autoclave

Consolidated Stills & Sterilizers 24D36
Sterilization. Chamber size is 24inch x36inch, Volume 9.4 cu. Ft

CCRI Biology Labs

Contact: David Vito

Balance - Analytical

Orion Analytical Balance
Weight determination with capacity of 60g.

CCRI Biology Labs

Contact: David Vito

Balance - Top Loading

EK-I Compact Balance
Weight determination (2 units)

CCRI Biology Labs

Contact: David Vito

Incubator

Fisher Scientific Isotemp Digital & Analog Dry Bath Incubator
Provide controlled dry heat environment for clinical & general chemistry applications

CCRI Biology Labs

Contact: David Vito

Electrophoresis System

Bio-Rad Mini-Protean Tetra Cell, Vertical protein electrophoresis gel boxes
Running Protein or DNA polyacrylamide gels

CCRI Biology Labs

Contact: David Vito

Microscope

Lieder MI-500 Series Compound Inverted Microscope
Tissue Culture

CCRI Biology Labs

Contact: David Vito

pH Meter

Thermo Scientific Orion 2-Star Bench Top pH Meter
General purpose measurements

CCRI Biology Labs

Contact: David Vito

Western Blotting System, Semi-Dry

Shelton Scientific Semi-Dry Blotting System
Transfer of protein, RNA & DNA gels to a solid membrane support for visualization, 24cmx30cm.

CCRI Biology Labs

Contact: David Vito

Spectrophotometer

Thermo Scientific Genesis 20 Visible Spectrophotometer
UV spectrophotometer for quantifying concentrations

CCRI Biology Labs

Contact: David Vito

Imaging System - Gel Imager - Transilluminator

FOTODYNE Foto Phoresis UV Transilluminator
Imaging-protein gel analysis, GFP Analysis

CCRI Biology Labs

Contact: David Vito

Incubator - Shaker

Lab Companion IS-971 Floor Model Incubator Shaker
Growing of bacteria, 250 L chamber

CCRI Biology Labs

Contact: David Vito

Biological Safety Cabinet

NuAire Class II Type A2
Maintain sterility and contain infectious work

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Chemical Hood

Labconco Protector Premier Fume Hood
Suitable for providing personal protection needed for general chemistry applications involving fumes and vapors.

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Incubator - Shaker

Lab Companion SI-600 Incubated Shaker
Bacterial culture shaker with a temperature of ambient to +60C.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

PCR Thermal Cycler

Bioer Life ECO thermal cycler
This thermal cycler has a 96 well format with a 2C/sec ramp rate.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

High Performance Liquid Chromatography (HPLC)

Agilent 1290 Infinity II
Modular UHPLC system with automated multisampler and quaternary pump for analyte separations up to 600 bar.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

High Performance Liquid Chromatography (HPLC)

Thermo Scientific nLC 1200
High-performance LC for nanoflow resolution of complex analyte mixtures at up to 1200 bar.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Cell Counter

Thermo Scientific Countess II Automated Cell Counter
Automated image analysis of cell suspensions providing rapid measurement of total cell counts, viability and average cell size.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Spectrophotometer

Thermo Scientific NanoDrop 2000
Measures DNA, RNA, and protein concentrations, and purity (A260/A280 ratio). Conc. range= 2 ng/microliter-15,000 ng/microliter; Min Sample size = 0.5 microliter.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

PCR Thermal Cycler

Applied Biosystems ProFlex thermal cycler
This thermal cycler has a 3x32 well format that allows for 3 separate programs to be run. The ramp rate is 6C/sec.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

PCR Thermal Cycler

Applied Biosystems Veriti thermal cycler
This thermal cycler has a 96 well format with 3.9C/sec ramp rate.

Extracellular Vesicle Core

Contact: Sicheng Wen MD, PhD, Director

PCR Thermal Cycler

ViiA 7 real-time PCR system with twister robot
We identify extracellular vesicles MicroRNA/mRNA profiling using the ABI TaqMan PCR array by ViiA 7 Real-Time PCR System, which is fully compatible with any standard or fast-cycling 384- or 96-well plates and TaqMan Array Micro Fluidic Cards and allows quickly and efficiently look up to 348 unique microRNAs/mRNAs per sample with as little as 1ng of input total RNA with pre-amplification.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

PCR Thermal Cycler

MJ Opticon 2 real-time PCR system.
This 96-well system accepts low-profile tubes or plates. There are two fluorophore channels with emission spectra in the 523-543 nm range and 540-700nm.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Incubator

(4) NuAire IR water-jacketed CO2 incubators (NU-8500)
This incubator provides an optimal in-vitro growth environment for both cell and tissue culture while minimizing dessication through a closed loop HEPA filtration system.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Biological Safety Cabinet

(4) NuAire Bio Safety Cabinets (Class II, Type A/B3)
These biological safety cabinets reduce exposure to airborne biological or particulate chemical agents in low to moderate risk-hazard research and/or drug preparations.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Centrifuge

Sorvall Legend X1R centrifuge
Process samples for diverse laboratory applications with rotors for 1.5ml eppendorf tubes, 15, and 50ml conical tubes. Refrigerated with a max speed of 152000 rpm.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Autoclave

Amerex HVE-50 top loading autoclave sterilizer
This is a 50L, self-contained, portable, top-loading autoclave with auto-exhaust and warming cycles.

Extracellular Vesicle Core

Contact: Sicheng Wen MD, PhD, Director

Analyzer - Nanoparticle Counter

NanoSight 5000 Nanoparticle Counter
Nanoparticle tracking analysis (NTA) – direct and real-time visualization and analysis of nanoparticles in liquids, and calculate the size, size distribution and concentration of the particles. Brownian motion of nanoparticles is analyzed using the Stokes-Einstein equation.

Extracellular Vesicle Core

Contact: Sicheng Wen MD, PhD, Director

Ultrafiltration

TangenX
By using tangential flow filtration (TFF) technology, TangenX delivers rapid and highly efficient isolation of extracellular vesicles from large volumes of samples.

Extracellular Vesicle Core

Contact: Sicheng Wen MD, PhD, Director

Centrifuge - Ultra

Thermo Fisher WX80 ultracentrifuge
Ultracentrifugation is the classical method for extracellular vesicles isolation. The Extracellular Vesicle Core contains two Thermo Fisher WX80 ultracentrifuges with Sorvall AH-629 rotors.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Luminometer

Promega Glomax 20/20 luminometer with printer
Ultrasensitive luminescence detection in a single microcentrifuge tube (1.5ml) format.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Oven - Hybridization Oven

Fisher Scientific Isotemp hybridization chamber
Temperature range of +7C to 85C. Includes a rotisserie.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Microplate Reader

Molecular Devices SpectraMax M2e plate reader
Features top and bottom read capability for absorbance, fluoresence, luminescence, and time-resolved fluorescence.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Bioanalyzer

Invitrogen Luminex 200 with xMap technology
This is a versatile, efficient standard in multiplexing with the ability to use magnetic or polystyrene beads on up to 100 targets/sample.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

pH Meter

Orion pH meter 920
pH range of -2 to 19.99 and oxygen range of -2 to 19.99ppm. Autocalibration buffers of 4.01, 7, and 10.01.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

pH meter

Hanna Instruments 2209
This pH meter features manual pH calibration and temperature compensation.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Incubator

GQF 1502 Sportsman egg incubator
This is a complete incubator and hatching system with 3 automatically turned racks. It has an accurate digital thermostat with LCD of humidity and temperature.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Homogenizer

Fisher Scientific, Powergen 125 Tissue Homogenizer
Process volumes from 0.03 to 100mL. Variable speed control to 30,000rpm for efficient cell disruption. Disposable plastic generators eliminate sample cross-contamination. Flat-bottom stainless-steel generators process liquid or soft tissues.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Disrupter

Qsonica 700W sonicator with 5.5" cup horn
This sonicator has full amplitude control from 1-100%.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

PCR Thermal Cycler - Digital

RainDrop Digital PCR by RainDance
The RainDrop is composed of a Source instrument that can generate 10million droplets/sample and the Sense instrument, which can detect whether the PCR reactions are positive or negative for your fluorophore. Multiplexing is possible for the 8 samples that are run at a time on the microfluidics chip.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

PCR Thermal Cycler

Bio-Rad CFX96 Real-Time PCR system
This real-time PCR instrument allows for up to 5-target multiplexing in sample volumes as small as 10ul. It also has a thermal gradient feature in a 96-well format.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Spectrophotometer

Thermo Scientific NanoDrop 2000c
This is a full spectrum, UV-Vis spectrophotometer used to quantify and assess the purity of DNA, RNA, protein, and more at sample volumes as low as 0.5ul.

Imaging and Molecular Biology and Nanomedicine Core

Contact: Lei Wei, PhD

Bioreactor

Flexcell FX5000 Tension System
This is a computer-regulated bioreactor that uses vacuum pressure to apply either cyclic or static strain to cells cultured on flexible-bottomed culture plates.

Lifespan-The Miriam Hospital
FacilityInstrument/Service/Resource Unit
Animal Models Core

Contact: Gerard Nau, MD

Biospecimen Banking - Freezer - -80 degrees

PHCbi
PHCbi TwinGuard Series upright -80°C freezer for sample storage. Two independent refrigeration systems provides redundancy for sample protection.

Animal Models Core

Contact: Gerard Nau, MD

PCR Thermal Cycler - Real-Time Detection System

Bio-Rad CFX Connect Real-Time PCR Detection System
CFX Connect Real-Time PCR System for two-target multiplex PCR and routine detection of single fluorophore experiments.

Animal Models Core

Contact: Gerard Nau, MD

Microplate Reader

Molecular Devices Spectramax i3X
The Spectramax i3X has the ability to measure absorbance, fluorescence, and luminescence. Additional features include fluorescence polarization and time-resolved fluorescence, along with injectors that facilitate flash based applications including dual luciferase and ATP assays.

Animal Models Core

Contact: Gerard Nau, MD

PCR Thermal Cycler - Droplet Digital

Bio-Rad QX200 Droplet Digital PCR System
Absolute quantification of target DNA or RNA molecules using EvaGreen or probe-based digital PCR applications. Flexible platform in groups of 8 with no standard curves necessary.

Animal Models Core

Contact: Gerard Nau, MD

Neutralization assay

Service
Luciferase-based assay used to measure the neutralization properties of serum, plasma, or monoclonal antibodies against SARS-CoV-2 based on a pseudotyped lentivirus.

Providence College
FacilityInstrument/Service/Resource Unit
PC - Albertus Magnus Hall Labs

Contact: Charles Toth

Microtome

Porter-Blum MT-2B Ultramicrotome
Porter-Blum MT-2B UltraMicrotomes, 2 Units

PC - Hickey Hall Labs

Contact: Charles Toth

PCR Thermal Cycler

Stratagene Mx3000p Real-time PCR Thermal Cycler
This instrument is available for gene expression analysis, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Agilent's qPCR software, MxPro, provides users with an intuitive interface, quick experiment design, powerful data analysis and easy report generation.

PC - Hickey Hall Labs

Contact: Charles Toth

Cold Room

Walk-In Cold Room

PC - Hickey Hall Labs

Contact: Charles Toth

Analyzer - Cell Metabolism

Seahorse Biosciencies, XFe Extracellular Flux Analyzers, XFe96
Platform for metabolic assays that simultaneously measures the two major energy producing pathways of the cell - mitochondrial respiration and glycolysis - in a microplate, in real-time.

PC - Hickey Hall Labs

Contact: Charles Toth

Laboratory - Tissue Culture

Tissue Culture Laboratory
Space and instrumentation for tissue culture preparation

PC - Hickey Hall Labs

Contact: Charles Toth

Imaging System - Gel Imager

LI-COR Odyssey IR (Infrared) Imaging System
Instrumentation for quantitating western blots.

PC - Hickey Hall Labs

Contact: Charles Toth

Fluorescence Activated Cell Sorter (FACS)

Cellometer Vision Image Cytometry
The Vision CBA System combines the simplicity of image cytometry with the power of flow analysis software to offer user-friendly cell-based assays

PC - Hickey Hall Labs

Contact: Charles Toth

Spectrophotometer

Thermo Scientific NanoDrop
UV/VIS

Rhode Island College
FacilityInstrument/Service/Resource Unit
RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Autoclave

Autoclave
Microbiology/Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Biological Safety Cabinet

Labconco class II Biological Safety Cabinet
Used for tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Biological Safety Cabinet

Sterile laminar flow hood
Microbiology prep

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Centrifuge

Eppendorf 5810R Refrigerated Centrifuge
Used for tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Centrifuge

Sorvall Discovery M120SE Mini Ultracentrifuge
Research/Cell fractionation

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Centrifuge

Sorvall Superspeed RC2 Centrifuge
General use

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Centrifuge

Sorvall Superspeed RC5 Plus Centrifuge
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Centrifuge

Thermo IEC Centra CL3R Refrigerated Centrifuge
Genetics and Cell & Molec courses

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Cold Room

Walk-In Cold Room
Large cold room for experimentation and storage

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Dishwasher

Dishwasher
Microbiology/Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Disrupter

French Pressure Cell Press
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Disrupter

Polytron Tissue Grinder
Slide/Sample Preparation

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Disrupter

Sonicator
General use and research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Disrupter

Sonicator with cup
Research and graduate courses

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Electroporation System

Bio-Rad Micropulser Electroporator
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Sample Preparation - Freeze Dry System

ATMO VAC 5009 freeze dryer
Slide/Sample Preparation

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Biospecimen Banking - Freezer

Thermolyne Liquid Nitrogen cryogenic storage system
Cell storage

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Biospecimen Banking - Freezer

Ultralow Freezer
Used for freezing biological samples, 6 units

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Imaging System - Gel Imager

InGenius Syngene Gel Documentation System
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Ice Machine

Ice Machine
General use

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Imaging System - Dark Room

Imaging System - Dark Room
Gel imaging and analysis

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Incubator

Non CO2 Incubator
Used for tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Incubator

Thermo CO2 Incubators
Used for tissue culture, 2 units

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Incubator

Refrigerated Incubator
Used for tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Laboratory - Tissue Culture

Tissue Culture Room
A room outfitted with tissue culture instrumentation

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microplate Reader

Lenovo Automated Plate Reader
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Microplate Reader

Thermo Labsystems Multiskan MMCC/340 plate reader
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Sample Preparation - Oven

Drying Oven
General use

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

PCR Thermal Cycler

Bio-Rad IQS Real time PCR thermocycler
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

PCR Thermal Cycler

Eppendorf Gradient Mastercycler
PCR instrumentation, 2 units

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Incubator - Shaker

Incubator/Shakers
Multiple units

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Spectrophotometer

BioRad SmartSpec Plus
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Spectrophotometer

Eppendorf Biophotometer
Gectrophotometerseral use

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Spectrophotometer

Spectronic 21 D UV/VIS
Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Spectrophotometer

Therm Spectronic Genesys UV/VIS Scanning
Research, 6 units

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Spectrophotometer

Thermo Scientific NanoDrop ND-1000
UV/VIS, 2 units

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Water Purification System

Barnstead Still Water Purifier
General use for teaching labs

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Water Purification System

Millipore DirectQ (X2)
Tissue culture

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Water Purification System

Millipore NanoPure Diamond
2nd floor research use

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Imaging System - X-ray Film

X-ray film processor
Blot imaging

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Autoclave

Autoclave
Microbiology/Research

RIC - Fogarty Life Sciences Labs

Contact: Dr. Rebeka Merson

Autoclave

Autoclave
Microbiology/Research

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Marine Science Research Facility

Contact: Dawn Outram

Fluorometer

Turner Designs 10-AU (Chlorophyll) Field Fluorometer
Measures extracted or in vivo chlorophyll fluorescence of samples, Field-portable, can be set up for continuous-flow monitoring or discrete sample analyses

Marine Science Research Facility

Contact: Dawn Outram

Incubator - Shaker

Thermo Max-Q Orbital Shaker Table
Orbital shaker with 18x24 in platform and variety of clamps

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker Avance III 300 with BBO probe
Optimized for small molecule NMR

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Nuclear Magnetic Resonance (NMR) Spectrometer

Varian 500 MHz NMR spectrometer
Optimized for small molecule NMR

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Synthesizer, DNA/RNA

MerMade-4 Oligonucleotide synthesizer
DNA/RNA Synthesizer

Rhode Island INBRE Molecular Informatics Core (MIC)

Contact: Christopher Hemme

Bioanalyzer

Agilent Bioanalyzer 2100
Provides fast and automated separation, sizing and quantification of DNA, RNA and proteins by miniaturized Lab-on-a-Chip electrophoresis

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Centrifuge

Beckman Avante High Speed Centrifuge
High speed centrifuge

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Centrifuge

Thermo MultiFuge Centrifuge table-top
Centrifuge

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Centrifuge - Ultra

Beckman Coulter Optima Beckman Optima L-100 XP ultracentrifuge
Ultra centrifuge

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Centrifuge - Ultra

Sorvall Micro Ultra Centrifuge
Ultra centrifuge

Marine Science Research Facility

Contact: Dawn Outram

Disrupter

Biospec Mini Bead Beater
Shakes tubes with beads to disrupt cells, DNA , RNA

Marine Science Research Facility

Contact: Dawn Outram

Disrupter

Branson Digital Ultasonic Liquid Sonifier
Disrupts cells

Rhode Island INBRE Molecular Informatics Core (MIC)

Contact: Christopher Hemme

Disrupter

Covaris S220 High Performance Ultrasonicator
Automated acoustic disruption and homogenization of cells and tissue samples using focused ultrasonic energy at 500 KHz. Performs DNA Shearing

Rhode Island INBRE Molecular Informatics Core (MIC)

Contact: Christopher Hemme

DNA Sequencer

Illumina MiSeq DNA NextGen Sequencing
Performs clonal amplification, genomic DNA sequencing, and data analysis with base calling, alignment, variant calling, and reporting.

Rhode Island INBRE Molecular Informatics Core (MIC)

Contact: Christopher Hemme

DNA Sequencer

Applied Biosystems 3500xl Genetic Analyzer
DNA Sanger Sequencing & Fragment Analysis: Fluorescence-based instruments utilizing capillary electrophoresis for DNA sequencing and fragment analysis.

Marine Science Research Facility

Contact: Dawn Outram

Fluorometer

Life Technologies Qubit Fluorometer
Quantifies DNA, RNA, and protein

Rhode Island INBRE Molecular Informatics Core (MIC)

Contact: Christopher Hemme

Fluorometer

Invitrogen Qubit
Fluorometer that uses fluorescent dyes bound to specific molecules to quantify DNA, RNA and proteins

Marine Science Research Facility

Contact: Dawn Outram

Homogenizer

Polytron Homogenizer PT-10-35-GT
Breaks down plant and animal tissue for analysis, and performs homogenization, dispersion, mixing, and prepares emulsions

Rhode Island INBRE Molecular Informatics Core (MIC)

Contact: Christopher Hemme

Sample Preparation - Library Preparation System

IntegenX Apollo 324 System NextGen Sequencing (NGS) Library Preparation System
Automated liquid handling instrument dedicated to the preparation of sample libraries for Next Generation Sequencing

Marine Science Research Facility

Contact: Dawn Outram

Microplate Reader

Molecular Devices Spectramax M5
Measures Fluorescence Intensity, Absorbance, Time Resolved Fluorescence, Fluorescence Polarization and Luminescence in cuvettes and multiple sized microplates.

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

PCR Thermal Cycler

Applied Biosystems/Life Technologies ABI Vii7- qPCR
Real Time-PCR

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

PCR Thermal Cycler

Eppendorf Mastercycler PCR
PCR

Marine Science Research Facility

Contact: Dawn Outram

PCR Thermal Cycler

Eppendorf Master Cycler Pro
Replicates DNA

Marine Science Research Facility

Contact: Dawn Outram

PCR Thermal Cycler

Stratagene QPCR Mx3000P
Analysis of gene expression, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Quantitative PCR Filters- FAM/Syber Green, Rox, Hex, CY3, CY5

Rhode Island INBRE Molecular Informatics Core (MIC)

Contact: Christopher Hemme

PCR Thermal Cycler

Roche LC480 qPCR Systems
Quantitative PCR (qPCR) instrument. Used for highly accurate qualitative and quantitative detection of nucleic acids and gene expression.

Marine Science Research Facility

Contact: Dawn Outram

Incubator - Shaker

Thermo Max Q Incubated Shaker
Heated incubated shaker

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Spectrophotometer

Thermo Scientific NanoDrop
UV/VIS

Marine Science Research Facility

Contact: Dawn Outram

Spectrophotometer

Thermo Scientific NanoDrop 1000
Microvolume UV-Vis spectrophotometer that quantifies DNA, RNA, and protein from small 1-2 microliter sample size

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Water Purification System - Deionized (DI)

Millipore Milli-Q Water System
DI Water System

Cell Analysis and Sorting Core

Contact: Alan Rothman, M.D., Research Professor

Microplate Reader

Perkin-Elmer Envision
Multimodal plate reader- absorbance, luminescence, fluorescence, time-resolved fluorescence, AlphaScreen

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Incubator

Heraeus Heracell Double Stacked Incubator
The Heraeus Heracell Double Stacked Incubator has Copper Chambers, which protects samples while optimizing cell growth with fast recovery characteristics.

Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Sample Preparation - Automated pipettor

Opentrons OT-2
Automated sample preparation platform for staining well plates

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Mass Spectrometer

ABSciex Qtrap 4500 Triple Quadrapole LC/MS
Has Shimadzu HPLC system attached

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Microplate Reader

Molecular Devices ID3 Microplate Reader
Uv/vis, Chemilumenesence, fluorescence

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Spectrophotometer

Genesys 50 UV/VIS
UV/Vis

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Imager and Microplate Reader

BioTek Cytation 5 Imager
fluorescence imaging

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Analyzer - Metabolism Analysis

Agilent Seahorse XFe96 Analyzer
96 well plate metabolism analysis

VA Providence Healthcare System
FacilityInstrument/Service/Resource Unit
Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Microarray Scanner

Illumina iScan
Whole-genome genotyping, gene expression analysis, methylation analysis

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Autoclave

Tuttnauer
Equipment: consumable sterilization

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Bioanalyzer

Agilent Bioanalyzer
DNA size & quantification (quality check for downstream analyses, i.e. next gen sequencing)

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Analyzer - Genetic

Applied Biosystems 3500 Genetic Analyzer
Capillary Electrophoresis - Analyze fragment length polymorphisms (96 format) (2)

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Centrifuge

Eppendorf Refrigerated Centrifuge
Alcohol precipitation

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Centrifuge

Eppendorf
For centrifuging 96/384 plates

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Mass Spectrometer

Sequenom
high throughput SNP genotyping, epigenetics

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Microplate Reader

BioTek
DNA quantification

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Microplate Reader

Fluidigm End Point Reader
High throughput SNP genotyping

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

PCR Thermal Cycler

Applied Biosystems
384 well DNA amplification for downstream analysis (i.e. sequenom processes) (2 units)

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

PCR Thermal Cycler

Applied Biosystems
96 well DNA amplification for downstream analysis (i.e. fragment length polymorphisms)(2 units)

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - DNA Extraction

Chemagen/Perkin Elmer Magnetic Separation Module
DNA extraction from blood & saliva

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - Liquid Handler

Sequenom Liquid Handler
Transfers PCR chemistries to samples (96/384 format)

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - Liquid Handler

Sequenom Nanodispenser
Dispenses PCR product to Sequenom chip

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - Sample Preparation

Iontorrent/Life Technologies Enrichment System
Simplifies the workflows for the Ion PGM system by providing an automated solution for scalable and reproducible template preparation.

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation - Sample Processing

Thermo Scientific Cap-it-All
Caps tubes to the optimal torque to maintain sample integrity and provide a hands free method to capping and decapping tubes quickly and easily.

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Robotic Workstation -Liquid Handler

Beckman Coulter Lab Automation Workstation
Automated liquid handler

Genomics Laboratory - Providence VA Medical Center

Contact: John McGeary, PhD

Spectrophotometer

Thermo Scientific NanoDrop
DNA quantification

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Channel Cycling Metabolic System

OmniTech ElectronicsModel #80 AP4RAT AccuPacer 4 Channel Rat Treadmill and #75 MS8 8
For rodent cardiopulmonary exercise testing

IDeA COBRE for CardioPulmonary Vascular Biology Core

Contact: Valeria Zarate

Spectrophotometer

NanoDrop
Measures the concentration of peptides, DNA and RNA, purified protein, nanoparticles, perform protein assays and optical density measurements

Nuclear Science

Rhode Island State Agency
FacilityInstrument/Service/Resource Unit
Rhode Island Nuclear Science Center

Contact: Dr. Cameron Goodwin

Reactor, Research and Test

2 Mega-Watt, light water cooled, pool type reactor
Neutron and gamma irradiation and experimental set-up, as well as analysis

Proteomics

Brown University
FacilityInstrument/Service/Resource Unit
Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Mass Spectrometer

Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer
Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer is a bench-top ESI LC-MS/MS system that combines quadrupole precursor ion selection with high-resolution, accurate-mass (HRAM) Orbitrap detection.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Analyzer - Calorimeter

Microcal Isothermal Titration 200 (ITC)
Characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Analyzer - Calorimeter

Microcal VP Differential Scanning (DSC)
Measurement of heat changes that occur in biomolecules during controlled increase or decrease in temperature.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Fluorometer - Spectrofluorometer

Horiba Jobin Yvon FluoroMax-4
Fluorescence detection. A heated cell allows temperature studies.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Spectrometer

JASCO J-815 Circular Dichroism (CD) Spectrometer
Protein folding studies, Protein conformational studies, DNA/RNA interactions, Enzyme kinetics, Purity testing of optically active substances, quantitative analysis of pharmaceuticals, natural products chemistry, biochemistry and macromolecules, rapid scanning (time resolved) experiments. Peltier device for temperature studies.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Spectrophotometer

Thermo Scientific NanoDrop 8000
A full spectral microvolume (microliter) UV-Vis analysis spectrophotometer for measuring DNA, RNA, and protein of 8 samples simultaneously.

Proteomics Facility - Brown

Contact: Mandar T Naik, PhD

Technical Assistance

Service
Service to provide Proteomics Technal Assistance

IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE)

Contact: Jennifer Tidey, Ph.D.

Analyzer - Automated Immunoassay System

ProteinSimple - Ella Next Generation ELISA system
The Ella mutiplex analyzer allows for multi-plexing of multiple biomarkers on the same cartridge. Rather than performing a separate ELISA for each biomarker with more sample volume to run in triplicate, the ELLA can multi-plex biomarkers in triplicate within a single well, increasing the amount of data that can be generated from clinical samples.

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Mass Spectrometer

Agilent LC/MSD VL mass spectrometer
The Agilent 1100 Series LC/MSD offers you the sensitivity, selectivity, and depth of molecular information inherent in mass spectrometry—in a package that is rugged, reliable, and surprisingly easy to learn, operate, and maintain

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

High Performance Liquid Chromatography (HPLC)

Agilent 1100 HPLC system

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Bioinformatics Analysis - MASCOT

Software: Matrix Science MASCOT Search Engine
Software for MS data analysis through statistical evaluation of matches between observed and projected peptide fragments.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Bioinformatics Analysis - ProteoIQ

Software: NuSep ProteoIQ Mass Spec Data Analysis
Software for post-analysis of MASCOT results. Protein and peptide probabilities generated and protein relative quantitation is performed by spectral counting. Normalized and with standard deviations.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Liquid Chromatography - Mass Spectrometer (LC - MS)

Thermo Scientific Q Exactive Plus Mass Spectrometer
LC-MS/MS system combines high-performance quadrupole with high resolution, accurate-mass (HR/AM) Orbitrap for total proteome characterization. Max resolving power= 140,000; max scan speed= 12Hz, Intra-scan dynamic range > 5000:, Quadrupole mass filter.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Technical Assistance - Mass Spectrometry

Service
Service to provide Imaging Mass Spectrometry Data Analysis.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Technical Assistance - Protein Determination

Service
Service to provide Protein Determination (BCA assay).

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Technical Assistance - Protein Extraction

Service
Service to provide ReadyPrep Protein Extraction Kit (Total Protein and Sequential Extraction).

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Technical Assistance - Protein In-Gel Digestion

Service
Service to provide In-gel digestion LC/MS analysis and protein database search.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Technical Assistance - Protein In-Solution Digestion

Service
Service to provide In-solution digestion LC/MS analysis and protein database search.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Technical Assistance - Protein Quantification

Service
Service to provide Data interpretation and protein quantification.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Technical Assistance - Protein Sample Clean-up

Service
Service to provide ReadyPrep 2D Cleanup Kit.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Mass Spectrometer

Thermo Scientific TSQ Quantiva
Triple-quadrupole MS for identification and absolute quantification of biomarkers, target proteins/peptides with known post-translational modifications in selected mass ranges.

Proteomics Core - Rhode Island Hospital

Contact: Paul Bertone, PhD

Microplate Reader

GloMax Discover - Multimode Detection System
Multi-mode detection instrument offering flexible use of filters and includes: high-performance, luminescence, fluorescence, UV-Visible absorbance, BRET and FRET, two-color filtered luminescence and kinetic measurement capabilities

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Chromatography

Metrohm Ion Chromatography 940 Vario
Ion Chromatography

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Electrophoresis System - Gel Electrophoresis

Bio-Rad 2D Gel System
Two Dimensional (2D) Gel Electrophoresis

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Liquid Chromatography

GE AKTA Fast Protein Liquid Chromatograph (FPLC)
FPLC

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Chromatography

Teledyne-ISCO CombiFlash System
Flash Chromatography

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Liquid Chromatography - Mass Spectrometer (LC - MS)

AB SCIEX TripleTOF 4600 and Shimadzu Prominence UFLC sytem
ESI-TOF MS

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Analyzer - Protein Quality

Tycho NT.6
The Tycho NT.6 verifies protein quality by looking at the structural integrity (or foldedness) of a protein. Changes in the intrinsic fluorescence of the sample are measured as a thermal ramp is applied. Changes in the fluorescence signal indicate transitions in the folding state of the protein. The Tycho can be used to study the stability of protein samples in different buffers or at different pH values. The measurement is completed in three minutes and uses a capillary tube to hold the sample.

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

High Performance Liquid Chromatography (HPLC)

Shimadzu Nexera-i HPLC system
High Performance Liquid Chromatography

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Mass Spectrometer

Shimadzu Axima MALDI-TOF MS/MS
MALDI MS

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Mass Spectrometer

Thermo iCAPQ-a ICP-MS
Elemental Analyzer

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Spectropolarimeter

Jasco J-1100 Circular Dichroism (CD) Spectropolarimeter
CD

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Spectrometer

Thermo Nicolet 380 Fourier Transformed Infrared Spectrometer (FT-IR)
FT-IR

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Characterization - Surface Plasmon Resonance

Biacore T200 SPR
The Biacore T200 is a surface plasmon resonance instrument which can be used to characterize molecular interactions between biomolecules ranging in size from ions to viruses. The Biacore software provides a range of tools for kinetic analyses. These analyses can be performed using a multicycle approach (many samples against one ligand or when different ligands are immobilized), or alternatively, using fast, single cycle kinetics.

Rhode Island INBRE Centralized Research Core Facility (CRCF)

Contact: Dr. Ang Cai

Western Blotting System

Bio-Rad Turbo Trans Blot system
Western Blotting

Repository

Brown University
FacilityInstrument/Service/Resource Unit
BioBank, Rhode Island

Contact: Garrett Sullivan

BioBank - Biospecimen Banking - Freezer - -80 degrees

Thermo Scientific HERAfreezer 24 cu. Ft. -80 degree freezer
(3) Biospecimen Storage at -80 degrees. Holds up to 50,000 1ml samples

BioBank, Rhode Island

Contact: Garrett Sullivan

BioBank - Biospecimen Banking - Refrigerator

LABREPCO FUTURA Platinum Series 52 cu. ft. glass door refrigerator
(3) Biospecimen Storage Refrigerators at 4 degrees. 4 degree hinged glass door refrigerator

BioBank, Rhode Island

Contact: Garrett Sullivan

BioBank - Robotic Workstation - Sample Preparation

Qiagen QiaCube
DNA, RNA or Protein Purification

BioBank, Rhode Island

Contact: Garrett Sullivan

Bioinformatics Analysis - Freezerworks

Software: Freezerworks 2019 Ver 11.01.00
Sample management software

BioBank, Rhode Island

Contact: Garrett Sullivan

BioBank - Biospecimen Banking

Service
Service to store biospecimens at -80 degrees, 4 degrees and in liquid nitrogen. All equipment is connected to back-up generator power and monitored 24/7 by a Rees alarm system.

BioBank, Rhode Island

Contact: Garrett Sullivan

BioBank - Biospecimen Banking - Freezer - Liquid Nitrogen

Taylor Wharton LABS 40K Liquid Nitrogen Storage System
(2) Liquid nitrogen biospecimen storage system. Holds up to 40,000 1ml samples

Molecular Pathology Core - Brown

Contact: David Silverberg

Biospecimen Banking - Freezer

Revco -80 degree C Freezer
Temporary Sample storage

CharterCARE - Roger Williams Medical Center
FacilityInstrument/Service/Resource Unit
Roger Williams Medical Center Resources

Contact: John W. Morgan, Ph.D.

Tissue Bank Core

Biospecimen Banking - Tissue Banking and Specimen access
The Tissue Repository Core (TRC) is designed to facilitate translational cancer research by procuring and storing diseased and normal control tissues, with the associated clinical data, for RWMC investigators and outside clients.

(Independent Nonprofit)
FacilityInstrument/Service/Resource Unit
Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

Incubators (2)

VWR Symphony CO2 incubator
CO2 incubators designed to maintain adequate interior moisture to prevent the drying out of cultures. 

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

BioBank - Biospecimen Banking - Freezer

Kenmore -20C Freezer
Sample storage

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

BioBank - Biospecimen Banking - Refrigerator

4C Glass Door
Sample storage

Mansfield Bio-Incubator

Contact: Alexander Margulis, PhD

BioBank - Biospecimen Banking - Freezer

NuAire -85C Ultralow Temp Freezer
Sample storage

Lifespan-The Miriam Hospital
FacilityInstrument/Service/Resource Unit
Biorepository Core

Contact: Evgeny Yakirevich

BioBank - Biospecimen Banking - Resource Center

Clinical Research Resources, Procurement, storage, tracking and release of clinical isolates
Central location of stocked well-characterized clinical isolates to be used for basic, translational and or applied research studies. Over 600 organisms collected to-date.

Biorepository Core

Contact: Evgeny Yakirevich

Profiling - Microorganism Resistance profiling

Clinical Research resources, Profiling
Confirm phenotypic resistance profile. Phenotypic susceptibility by broth microdilution, gradient diffusion. Sensititre commercial BMD trays

Biorepository Core

Contact: Evgeny Yakirevich

Analysis - Microorganism Clinical isolates

Genotypic identification of isolates
Verify and confirm microorganism identification. 16s ribosomal sequencing, rRNA internal transcribed spacer (ITS) regions.

Biorepository Core

Contact: Evgeny Yakirevich

BioBank - Biospecimen Banking - Freezer -80 degrees

Thermo Fisher Scientific REVCO RDE60086FA
Clinical isolates stored at -80 degrees freezer in 1ml glycerol stock tubes

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

Sample preparation - Plunge freezer

FEI Vitrobot Mark 2 Plunge Freezer for cryoTEM
Automatic plunge freezer for cryoTEM sample preparation

Research Integrity and Compliance

Brown University
FacilityInstrument/Service/Resource Unit
Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IRB - University of Rhode Island

Human Subjects Protection
The University of Rhode Island Institutional Review Board (IRB) reviews research projects which involve human subjects to ensure that two broad standards are upheld: first, that subjects are not placed at undue risk; second, that they give uncoerced, informed consent to their participation.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IRB - Lifespan - Rhode Island Hospital and The Miriam Hospital

Human Subjects Protection
The Institutional Review Board (IRB) is a committee made up of physicians, scientists and community members who ensure that research involving human research subjects is well planned and ethical. All research that involves human subjects or their identifiable data must be reviewed by the IRB.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IRB - Care New England - Butler Hospital

Human Subjects Protection

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IACUC - Care New England - Women and Infants

Animal Subjects Protection

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IRB - Care New England - Women and Infants Hospital

Human Subjects Protection
Women & Infants Institutional Review Board (IRB) is a committee established to review and approve research involving human subjects. The purpose of the IRB is to protect the rights and welfare of human research subjects and to ensure that all human subject research be conducted in accordance with federal, state, institutional, and ethical guidelines.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IACUC - University of Rhode Island

Animal Subjects Protection
The URI Institutional Animal Care and Use Committee (IACUC) is responsible for overseeing the provisions for the care and well -being of animals used for research and educational purposes at the University and serves the public by ensuring compliance with all legal and ethical standards regarding the use of vertebrate animals in research and teaching at URI.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IRB - Care New England - Kent Hospital

Human Subjects Protection

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IRB - VA Providence Healthcare System

Human Subjects Protection

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IACUC - VA Providence Healthcare System

Animal Subjects Protection

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IRB - Brown

Human Subjects Protection
The IRB is a diverse body of Brown faculty researchers, physicians, staff and unaffiliated community members appointed by Brown’s Vice President for Research and charged with reviewing human subject research protocols to uphold two broad standards To ensure that participants are not placed at undue risk; and To ensure that participants give informed consent to their participation free of coercion or undue influence To this end, projects that meet the regulatory definition of human subject research must be reviewed and approved by the IRB prior to initiation.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IACUC - Lifespan - Rhode Island Hospital

Animal Subjects Protection
The Animal Welfare Committee (IACUC) is a committee made up of scientists and community members who ensure that research involving animal subjects is well planned and ethical.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

Export Controls - University of Rhode Island

Research Compliance, Export Controls
The Export Controls office ensures that all personnel, including employees, visiting scientists, postdoctoral fellows, students, and other persons retained by or working at or for URI conduct their affairs in accordance with U.S. laws and regulations, including compliance with U.S. export control laws and regulations applicable to its operations.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

Biosafety - Lifespan - Rhode Island Hospital and The Miriam Hospital

Research Compliance, Biosafety
The Biohazards and Laboratory Safety Committee reviews and approves the use of potentially hazardous agents in the laboratory setting.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

Export Controls - Brown

Research Compliance, Export Controls
Export Controls regulate the shipment or transfer, by whatever means, of controlled items, software, technology, or services out of the U.S. and also restricts the release of certain information to foreign nationals here in the U.S.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

Biosafety - University of Rhode Island

Research Compliance, Biosafety
The Institutional Biosafety Committee (IBC) reviews and approves Biological Research protocols.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

Biosafety - Brown

Research Compliance, Biosafety
The Institutional Biosafety Committee (IBC) evaluates and provides oversight of the use of biohazardous agents to ensure compliance with appropriate regulations and guidelines and to safeguard the health and safety of Brown University personnel, the community, and the environment.

Research Integrity and Compliance-Multi-institutions

Contact: AdvanceRI@brown.edu

IACUC - Brown University

Animal Subjects Protection
The ARPP is the administrative office dedicated to facilitating the submission, review and approval of IACUC protocols, supporting the various functions of the IACUC, and providing individual assistance to researchers whenever needed.

Statistics

Brown University
FacilityInstrument/Service/Resource Unit
Biostatistics, Epidemiology, and Research Design Core (BERD)

Contact: Chris Schmid, PhD

Biostatistics Services

Clinical Research Resources, Biomedical Informatics
Quantitative Research Support, Qualitative and Mixed Method Research Support

Biostatistics, Epidemiology, and Research Design Core (BERD)

Contact: Chris Schmid, PhD

Workshops, Seminars, Trainings

Clinical Research Resources, Biomedical Informatics
Symposia, REDCap Workshop, Online Tutorials, Biostatistics Core Seminar Series, Drop-In Sessions

Lifespan - Rhode Island Hospital
FacilityInstrument/Service/Resource Unit
IDeA COBRE on Opioids and Overdose

Contact: Heather Wunschel

Translational and Transformative Core

Service
The Translational and Transformation (T2) Core provides technical assistance in the execution of translation and implementation of science research and supports the dissemination of innovative findings to transform care for opioid addiction and overdose.

IDeA COBRE on Opioids and Overdose

Contact: Heather Wunschel

Data and Research Methods Core

Service
The Data and Research Methods (DRM) Core provides study design and methodological expertise, delivers data management resources, offers data visualization services, and addresses analytical needs shared by investigators who lack access to these resources within their own research groups.

Lifespan Biostatistics, Epidemiology, and Research Design (BERD)

Contact: Jason Machan, PhD 

Technical Assistance - Biostatistics, Epidemiology, and Research Design Consulting

Service
The Biostatistics, Epidemiology, and Research Design (BERD) Core at Rhode Island Hospital offers centralized biostatistics consultation services to clinical, basic, and translational researchers. We provide a broad array of resources during all phases of research. During planning, the core can provide high quality project/trial design, including final sculpting of specific aims and hypotheses, measure selection, power analysis, data analysis planning, and grant/proposal preparation. At the beginning of the project, the core can assist in construction of REDCap data collection tools, databases, and data management, including national archiving. We provide help navigating approvals for special technology needs, such as purchasing non-standard equipment and logistics. Throughout the trial, the core can provide decision support, assessing the impact of potential design additions or changes on final statistical inference. It can serve on or help find individuals to serve on data and safety monitoring boards (DSMB). At the conclusion of the trial, the core can assist with implementation of the data analysis plan, either by providing access to contemporary statistical analysis software and coaching, or by conducting analyses for or with investigators. During reporting/publication preparation, the core can assist in write-up, data visualization, and integration of interpretations in the broader context of the project, and help address comments from peer reviewers.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Rhode Island INBRE Molecular Informatics Core (MIC)

Contact: Christopher Hemme

Bioinformatics Analysis

Service - Bioinformatics
We provide bioinformatics consultation and services to the Rhode Island INBRE community and to the general scientific community of Rhode Island. In addition to traditional bioinformatic services, our Core is expanding to 3D/VR/AR visualization services in conjunction with the URI 3D Visualization Laboratory. We are currently developing 3D/VR visualization apps for a variety of platforms including smartphones, Vive/SteamVR, and others. We also have access to the 3D printer at the URI 3D Visualization Core for printing of marcomolecules at a reasonable price.

Structural Biology & Chemistry

Brown University
FacilityInstrument/Service/Resource Unit
NMR Facility

Contact: Russell Hopson, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 600 Avance III HD Ascend
z-BBFO probe for all nuclei (most sensitive for all nuclei)

NMR Facility

Contact: Russell Hopson, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 400 Avance III Ultra-Shield
z-BBFO probe (2nd most sensitive for 1H and broadband nuclei) - (HR-MAS probe)

NMR Facility

Contact: Russell Hopson, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 400 Avance Ultra-Shield
z-BBO (3rd best sensitivity for broadband nuclei)

Structural Biology Facility

Contact: Mandar T Naik, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 500 Avance II
An NMR spectrometer optimized for studying proteins in solution. This spectrometer is most useful for tracking binding interactions, measuring dynamic properties of proteins, and assigning protein resonances. Capable of using 5 mm and 3 mm tubes. Also suitable for proton NMR of small molecules and natural products.

Structural Biology Facility

Contact: Mandar T Naik, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker 850 MHz Avance III HD, with TCI cryoprobe
An NMR spectrometer optimized for studying proteins in solution. This spectrometer is ideal for determining protein structures and measuring protein dynamics. Its extreme sensitivity allows studies on otherwise intractable samples. Capable of using 5 mm, 3 mm, and shaped NMR tubes. Also suitable for proton NMR of small molecules and natural products

Structural Biology Facility

Contact: Mandar T Naik, PhD

X-Ray Diffraction System

Rigaku ACTOR robot and Saturn 944 HG CCD
An instrument useful for obtaining X-ray diffraction patterns of proteins and other biomacromolecules under cryogenic or room-temperature conditions. Rapid screening and sorting of up to 80 candidate crystals is possible.

Structural Biology Facility

Contact: Mandar T Naik, PhD

Nuclear Magnetic Resonance (NMR) Spectrometer

Bruker AVANCE III HD 600 MHz High Performance Digital NMR Spectrometer
Bruker NEO 600 MHz NMR spectrometer for high resolution solution-state protein NMR experiments 4 RF channels, triple-resonance (1H-13C-15N) inverse cryoprobe with cooled 1H, 13C and 15N preamplifiers.

The University of Rhode Island
FacilityInstrument/Service/Resource Unit
Rhode Island Consortium for Nanoscience and Nanotechnology

Contact: Dr. Irene Andreu, PhD

X-Ray Diffraction System

Rigaku Ultima IV multipurpose X-ray diffraction (XRD) system
micro-crystalline diffraction, thin-film diffraction, small angle scattering, and in-plane scattering.

Transgenics & Gene Targeting

Brown University
FacilityInstrument/Service/Resource Unit
Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Biological Safety Cabinet

NuAire Safety Cabinets Class 2 Type A/B3
Transgenics and gene targeting safety cabinets (2 units)

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Centrifuge

Thermo IEC Centra CL3R Refrigerated Centrifuge
Transgenics and gene targeting refrigerated centrifuge

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Electroporation System

Bio-Rad Gene Pulsar II
Transgenics and gene targeting electroporation system

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Biospecimen Banking - Freezer

Custom BioGenic Systems Liquid Nitrogen (LN2) Freezer
Transgenics and gene targeting liquid nitrogen freezer

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Biospecimen Banking - Freezer

Thermo Fisher Scientific -80 C
Transgenics and gene targeting -80 C freezer

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Biospecimen Banking - Freezer

Frigidaire -20 C Freezer
Transgenics and gene targeting freezer

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - ES Cell Gene Targeting System

Service
Gene targeting services through transfection and microinjection of murine embryonic stem (ES) cells to produce germline knockout (KO) or knockin (KI) mice.

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Incubator

NuAire CO2 water jacketed Incubators
Transgenics and gene targeting incubators (3 units)

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Cell Manipulator - Microinjection system

Eppendorf FemtoJet Microinjection System
Transgenics and gene targeting pronuclear injection system

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Micromanipulator

Eppendorf Transferman NK 2 Micromanipulators
Transgenics and gene targeting micromanipulators (2 units)

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Transgenesis by Random Integrations

Service
Service to provide custom services related to microinjection, ES cell culture, mouse surgery, or mouse reproduction. The core facility will provide services and/or training related to our capabilities that are not specifically covered by our service list. These services are available for an hourly fee. Examples include: production of MEFs (murine embryonic fibroblasts), polar body biopsy, reproductive surgery, blastomere injection, frozen embryo shipment, training

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Mouse Line Recovery from Cryopreservation

Service
Service to thaw and implant previously cryopreserved mouse embryos From frozen embryos or frozen sperm.

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Cryopreserved Mouse Embryo Storage

Service
Service to store cryopreserved mouse embryos in liquid nitrogen (LN2)

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Derivation of Mouse Embryonic Stem (ES) cell lines

Service
Service to produce embryonic stem (ES) cells from an existing mouse line key words: murine embryonic stem cells

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Chimeric Mouse Production

Service
Service to produce chimeric mice for analysis through microinjection of murine embryonic stem (ES) cells into blastocyst stage embryos.

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Mouse Colony Expansion

Service
Service to use superovulation and surgical implantation to produce large cohorts of age matched mice for experimentation or to quickly expand a mouse colony

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Mouse Embryo Cryopreservation

Service
Service to cryopreserve valuable mouse lines for storage or shipment to other investigators. Heterozygous embryos or Homozygous embryos

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Mouse In vitro Fertilization (IVF)

Service
Service to perform in vitro fertilization of mouse embryos using fresh or frozen sperm.

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Rederivation of Mouse Lines

Service
Service to rederive mouse lines obtained from a source other than a Brown University approved vendor. Rederived mouse lines may be housed in any campus mouse facility.

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Transgenics and Gene Targeting - Embryo Microinjection/Electroporation

Service
Service to perform pronuclear microinjection of 0.5 dpc mouse embryos to produce transgenic or CRISPR founders on an FVB/N or C57/BL6 background. Custom backgrounds also available.

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Biospecimen Banking - Freezer

SP Scientific, Bio-cool IV40A
Embryo cryopreservation at a controlled slow rate

Mouse Transgenic and Gene Targeting Facility

Contact: Jinping Luo, PhD

Microinjection system

Prime Tech, Piezo Drive PMM4G
Intracytoplasmic sperm injection