Instrument/Service

Facility	Instrument/Service/Resource Unit	Manufacturer/Functions
Advance-CTR	Administration Advance-CTRResearch Resources	Clinical Research Service, Advance-CTR Service Coordination Advance-CTR works to support researchers at the state level by developing the infrastructure and resources investigators need to conduct clinical and translational research in Rhode Island. Through its interdisciplinary and inter-institutional model, Advance-CTR funds and supports research across the translational science spectrum, including basic science, clinical, and public health efforts. Ultimately, Advance-CTR seeks to connect researchers and support institutions in Rhode Island in order to advance clinical and translational research that improves public health in the state.
Advance-CTR	Research - Biostatistical Consulting, Epidemiology & Clinical Research Design Services Contact: Heather Fournier Biostatistical Consulting, Epidemiology & Clinical Research Design Services Webpage	Clinical Research Service, Advance-CTR A team of experienced statisticians and methodological experts are on-hand to help investigators prepare their proposals pre-award, and plan their projects upon receipt of funding. Pre-award services include, positioning of specific aims and hypotheses, measure selection, power analysis and data analysis planning. Post-award services include decision support services, data acquisition and management and consultations to assess the impact of potential design changes on final statistical influence. Data analysis and results interpretation services include implementing data analysis plans, statistical analysis consultations, selecting and accessing statistical analysis software, and coaching to best utilize statistical analysis software. Manuscript and grant proposal writing services include assistance with write-ups, data visualizations, integration of interpretations in the broader context of the project, and addressing comments from peer reviewers.
Advance-CTR	Research - Biomedical Informatics Services Contact: Heather Fournier Biomedical Informatics Services Webpage	Clinical Research Service, Advance-CTR Researchers may request, access, and use data available through the Unified Research data Sharing Access (URSA) infrastructure. The data include information originating from electronic health data systems at Lifespan, Care New England, and the Rhode Island Quality Institute, as well as from publicly accessible biological and health data sets.
Advance-CTR	Research - Qualitative Methods Services Contact: Heather Fournier Qualitative Services Webpage	Clinical Research Service, Advance-CTR This service provides qualitative and mixed methods and data analysis design research support. Qualitative and mixed methods support includes; study design and preparation, original measure development, coaching on qualitative methods design decisions (focus groups, interviews, cognitive interviews), NVivo qualitative software training, help with grant writing of qualitative methods and analysis sections, manuscript and grant proposal review, post interview/focus group debriefing. Data analysis design support includes applied thematic analysis and framework matrix analysis.
Advance-CTR	Research - Community Engagement & Outreach CoreCommunity Engagement & Outreach Core	Clinical Research Service, Advance-CTR The CEO Core helps facilitate research endeavors that are relevant, accessible, and impactful to the entire state of Rhode Island.
Animal Models Core	Support for in-vivo experiments	Service Personnel available to assist with planning and executing BSL1 and BSL2 animal experiments with an emphasis on blinding treatments and/or assessments to enhance robustness.
Animal Models Core	Imaging System - fluorescent and bioluminescent	PerkinElmer IVIS Lumina III in vivo imaging system The IVIS Lumina III is capable of imaging both fluorescent and bioluminescent reporters. The system is equipped with up to 26 filter sets that can be used to image reporters that emit from green to near-infrared. Superior spectral unmixing can be achieved by Lumina III’s optional high resolution short cut off filters.
Animal Models Core	Flow Cytometer	Amnis CellStream Luminex Flow Cytometer The CellStream flow cytometer has single tube and 96 well plate capabilities with automatic compensation. Equipped with 405nm, 488nm, 532nm, and 642nm lasers and 16 fluorescent channels. Handles BSL-1 and fixed samples from BSL-2 experiments.
Animal Models Core	Liquid nitrogen storage	CBS Cryosystems 4000 Series CBS cryosystems 4000 series liquid nitrogen freezer for eukaryotic cell storage.
Animal Models Core	PCR Thermal Cycler - Real-Time Detection System	Bio-Rad CFX Connect Real-Time PCR Detection System CFX Connect Real-Time PCR System for two-target multiplex PCR and routine detection of single fluorophore experiments.
Animal Models Core	Neutralization assay	Service Luciferase-based assay used to measure the neutralization properties of serum, plasma, or monoclonal antibodies against SARS-CoV-2 based on a pseudotyped lentivirus.
Animal Models Core	PCR Thermal Cycler - Droplet Digital	Bio-Rad QX200 Droplet Digital PCR System Absolute quantification of target DNA or RNA molecules using EvaGreen or probe-based digital PCR applications. Flexible platform in groups of 8 with no standard curves necessary.
Animal Models Core	Microplate Reader	Molecular Devices Spectramax i3X The Spectramax i3X has the ability to measure absorbance, fluorescence, and luminescence. Additional features include fluorescence polarization and time-resolved fluorescence, along with injectors that facilitate flash based applications including dual luciferase and ATP assays.
Animal Models Core	Biospecimen Banking - Freezer - -80 degrees	PHCbi PHCbi TwinGuard Series upright -80°C freezer for sample storage. Two independent refrigeration systems provides redundancy for sample protection.
Behavior and Neuroimaging Core	Training and Technical Assistance - Support	Clinical Research Resources, Behavior and Neuroimaging The mission of the Behavior and Neuroimaging Core (BNC) is to provide a coherent set of resources that will facilitate the implementation of each of the COBRE Project Leader’s research aims. The BNC provides ongoing support, training, assistance and advice to COBRE project leaders in the practical aspects of data collection, data management and data processing across a wide variety of neuroscience related methodologies. The BNC also serves as a resource to the broader neuroscience community at Brown and its affiliated hospitals and the broader Rhode Island academic community by providing formal and informal training, accessible data processing pipelines, and documentation of these and related resources. The support provided by the BNC is distinct from but complementary to services provided by the Design and Analysis Core (DAC). Whereas the DAC is focused primarily on study design, analytical modeling, and techniques for inference, the focus of the BNC is on practical aspects of research conduct such as efficient and high-quality data acquisition, implementation and deployment of standard and newly developed tools for analysis of large neuroimaging datasets, and lowering barriers to the use of such tools through direct assistance, training and documentation. Because the missions of the BNC and DAC are highly complementary, the effectiveness of each core is strengthened by collaborative relationships between them. The analytical techniques developed by the DAC in partnership with the Project Leaders are predicated upon robust high-quality data. Similarly, realization of study design principles requires practical expertise with the tools necessary to implement those principles. The BNC and DAC will share a full-time staff member with expertise in research design, statistical modeling, data management and high-performance computing.
Behavior and Neuroimaging Core	Training and Technical Assistance - Facilitate Experimental Implementations	Clinical Research Resources, Behavior and Neuroimaging Control experiments, Eye tracking, EEG guidance
Behavior and Neuroimaging Core	Training and Technical Assistance - MRI Assistance	Clinical Research Resources, Behavior and Neuroimaging Design of experiments, Analysis pipelines, EEG in the MRI scanner, Timing verification
Behavior and Neuroimaging Core	Data Storage - Generalized Solutions	Clinical Research Resources, Behavior and Neuroimaging xNAT database, Containers for data presentation, Beyond the desktop with VMs
Behavior and Neuroimaging Core	Training and Technical Assistance - High Performance Computing (HPC)	Clinical Research Resources, Behavior and Neuroimaging Assistance with High Performance Computing (HPC)
Benedum Stable Isotope Facility	Mass Spectrometer, Isotope Ratio	ThermoFisher (Finnigan) 253+ dual inlet Isotope Ratio Mass Spectrometer with automated sample reaction device for up to 48 samples and with Kiel IV Carbonate interface and PoraPak purification trap. Instrument primarily dedicated to the measurement of the stable isotopes of carbon and oxygen on inorganic carbonates as well as clumped oxygen isotopes. The facility accommodates projects both internal and external to Brown including analysis of terrestrial and marine material. The vast majority of samples analyzed are funded through external grants but we also facilitate a significant number of small unfunded, exploratory, analyses to help construct proof-of-concept data sets in preparation for proposals.
BioBank, BrainTissue	BioBank - Brain Tissue Resource Center	Clinical Research Resources, Brain Tissues A brain tissue resource center (BTRC) (often referred to as a brain bank) is a collection of human tissue specimens from the nervous system: the brain, spinal cord, muscle and peripheral nerves. The facility is engaged in a variety of functions; rapid specimen transport, tissue processing, state-of-the-art preservation methods and database management. A variety of experts, research doctors, neuropathologists and laboratory specialists, plan and manage the BTRC. Strict protocol is imposed on outside vendors whenever their services are required, particularly with respect to rapid specimen transport.
BioBank, Rhode Island	Bioinformatics Analysis - Freezerworks	Software: Freezerworks 2019 Ver 11.01.00 Sample management software
BioBank, Rhode Island	BioBank - Biospecimen Banking	Service Service to store biospecimens at -80 degrees, 4 degrees and in liquid nitrogen. All equipment is connected to back-up generator power and monitored 24/7 by a Rees alarm system.
BioBank, Rhode Island	BioBank - Biospecimen Banking - Freezer - Liquid Nitrogen	Taylor Wharton LABS 40K Liquid Nitrogen Storage System (2) Liquid nitrogen biospecimen storage system. Holds up to 40,000 1ml samples
BioBank, Rhode Island	BioBank - Biospecimen Banking - Freezer - -80 degrees	Thermo Scientific HERAfreezer 24 cu. Ft. -80 degree freezer (3) Biospecimen Storage at -80 degrees. Holds up to 50,000 1ml samples
BioBank, Rhode Island	BioBank - Biospecimen Banking - Refrigerator	LABREPCO FUTURA Platinum Series 52 cu. ft. glass door refrigerator (3) Biospecimen Storage Refrigerators at 4 degrees. 4 degree hinged glass door refrigerator
BioBank, Rhode Island	BioBank - Robotic Workstation - Sample Preparation	Qiagen QiaCube DNA, RNA or Protein Purification
Bioengineering Core	Analysis System - Gait	Noldus Catwlak small animal system
Bioengineering Core	Analysis System - Force Plate	Kistler 5 KN portable (6 channel)
Bioengineering Core	Electromyography (EMG) monitor	Noraxon Wireless EMG system (8 channel)
Bioengineering Core	Testing Systems	Bose Corp Biaxial ELF 3200 material test system Force Testers (Tension, Compression, Pull Testers). The ELF 3200 Series perform basic materials tests including axial, axial/torsion, fretting, biaxial, and planar biaxial fatigue tests.
Bioengineering Core	Testing Systems	Instron Electropuls E1000 All-Electric Dynamic Test Instrument designed for dynamic and static testing on a wide range of materials and components.
Bioengineering Core	Testing Systems	Instron 8521S Axial-Torsional Fatigue Testing System
Bioengineering Core	Testing Systems	MTS Bionix Electromechanical Torsion System Torsion Test System
Bioengineering Core	Testing Systems	Instron E10000LT Biaxial material test system
Bioengineering Core	Microscope	Asylum Research MFP-3D-BIO Atomic Force Microscope
Bioengineering Core	Microscope	Nikon TiU inverted microscope Inverted Microscope
Bioengineering Core	Imaging System - Camera	Qualisys Oqus 5-Series The Oqus cameras are designed to capture accurate mocap data with very low latency and works with both passive and active markers.
Bioengineering Core	Analyzer - Motion	Northern Digital Optotrak System Track and analyze kinetics and dynamic motion in real-time
Bioengineering Core	Analysis System - Force Plate	Tekscan Force Plate Walkway Low profile floor walkway system that captures multiple sequential foot strikes of animals.
Bioengineering Core	Analyzer - Pressure	Tekscan I-scan Pressure Mapping System
Bioengineering Core	Analysis System - Mapping System	Fuji Film Prescale Pressuregraph (FPD-901E) Pressure Distribution Mapping System
Bioengineering Core	Pendulum	Custom Active pendulum (small animal joint) System to induce frictional wear in arthrodial joints
Bioengineering Core	Pendulum	Custom Passive pendulums (small and large animal joints) System to measure the whole joint coefficient of friction
Bioengineering Core	Loading Device	Custom Biaxial Loading Device Tissue Engineering
Bioengineering Core	Tissue Engineering System	ICCT Technologies Bio-Stretch Uniaxial System Mechanical Stretching for Tissue Engineering
Bioengineering Core	Analysis System - Gait	Tekscan High Resolution Walkway (HRV6) Modular pressure measurement platform for gait analysis.
Bioengineering Core	Testing Equipment	KUKA KR6 700 SIXX 6 DOF joint motion testing
Biomedical Informatics Core	Biomedical Informatics Services	Clinical Research Resources, Biomedical Informatics Data Requests Storage and management Processing and analysis Submission and dissemination Software and Applications Requests Development REDCap Studies/Projects Project setup Education 5x5 Clinical Informatics elective Biomedical Informatics Learning Series Grant Support
Biomedical Informatics Core	Biomedical Informatics Resources	Clinical Research Resources, Biomedical Informatics Cohort Identification i2b2 tranSMART [local] i2b2/SHRINE [regional] TriNetX [national] Data Collection and Management Statewide REDCap instance Wrike and SPARCRequest Data Access and Use Unified Data Sharing & Analysis (URSA) Initiative URSA stronghold URSA data requests URSA governance URSA computational tools Subject Recruitment Research Networking and Resources
Biorepository Core	BioBank - Biospecimen Banking - Resource Center Contact: Tao Hong	Clinical Research Resources, Procurement, storage, tracking and release of clinical isolates Central location of stocked well-characterized clinical isolates to be used for basic, translational and or applied research studies. Over 600 organisms collected to-date.
Biorepository Core	Profiling - Microorganism Resistance profiling Contact: Tao Hong	Clinical Research resources, Profiling Confirm phenotypic resistance profile. Phenotypic susceptibility by broth microdilution, gradient diffusion. Sensititre commercial BMD trays
Biorepository Core	Analysis - Microorganism Clinical isolates Contact: Tao Hong	Genotypic identification of isolates Verify and confirm microorganism identification. 16s ribosomal sequencing, rRNA internal transcribed spacer (ITS) regions.
Biorepository Core	DNA Sequencer Contact: Tao Hong	Illumina iseq 100 Illumina assay instrument FS10001514 Genotypic profiling by whole genome sequencing 16S metagenomic sequencing. Antimicrobial resistance detection by gene sequencing
Biorepository Core	BioBank - Biospecimen Banking - Freezer -80 degrees Contact: Tao Hong	Thermo Fisher Scientific REVCO RDE60086FA Clinical isolates stored at -80 degrees freezer in 1ml glycerol stock tubes
Biostatistics, Epidemiology, and Research Design Core (BERD)	Biostatistics Services	Clinical Research Resources, Biomedical Informatics Quantitative Research Support, Qualitative and Mixed Method Research Support
Biostatistics, Epidemiology, and Research Design Core (BERD)	Workshops, Seminars, Trainings	Clinical Research Resources, Biomedical Informatics Symposia, REDCap Workshop, Online Tutorials, Biostatistics Core Seminar Series, Drop-In Sessions
Bradley Hasbro Children's Research Center Resources	Research - Child Development and Mental Health Research Contact: Gregory K. Fritz, MD Child Development and Mental Health Research	Clinical Research Resources, Child Development The Bradley Hasbro Children's Research Center (BHCRC) encompasses a broad spectrum of research programs that share a commitment to studying the impact of psychological factors on the growth and development of children and their families. BHCRC investigators are exploring new insights into the genetic roots of autism; finding pediatric bio-behavioral markers of bipolar disorder; creating effective therapies for OCD; devising effective prevention strategies for adolescent sexual risk behaviors and obesity; and much more. Areas of interest include child and adolescent psychiatric disorders, forensic issues and juvenile justice, pediatric behavioral health, biological basis of psychiatric disorders, prevention and early intervention, and health services research.
Bradley Hasbro Children's Research Center Resources	Research - Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program Contact: Daniel Dickstein, MD Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program	Clinical Research Service, Pediatric Imaging The goal of the Pediatric Mood, Imaging and Neurodevelopment (Pedi-MIND) program is to identify biological and behavioral markers of psychiatric illness in children and adolescents in order to improve diagnosis, treatment, and prevention of these conditions.
Bradley Hasbro Children's Research Center Resources	Research - Rhode Island Consortium for Autism Research & Treatment (RI-CART) Contact: RICART RI-CART Website	Clinical Research Resources, Autism The Rhode Island Consortium for Autism Research & Treatment (RI-CART) is working to improve the lives of Rhode Islanders with autism spectrum disorder and related neurodevelopmental disorders by promoting collaborative, cutting-edge research, improving health care and support services, and providing data-driven education and advocacy. We’re a community of families and individuals, researchers, clinicians, educators, and local agencies focused on both today’s and future generations.
Bradley Hasbro Children's Research Center Resources	Research - Bradley Hospital Sleep and Chronobiology Research Laboratory (Sleep Lab) Contact: Mary A. Carskadon, MD Sleep for Science (Sleep Research Lab) Website	Clinical Research Resources, Sleep Sleep for Science is a program of research focusing on understanding how sleep patterns are shaped and how they affect other activities, functions, and biological processes. Our research is chiefly about sleep patterns and processes in young humans – children, teens, and young adults.
Bradley Hasbro Children's Research Center Resources	Research - Developmental Disorders Genetics Research Contact: Eric Morrow DDGRP Website	Clinical Research Resources, Developmental Genetics The Developmental Disorders Genetics Research Program was established in the fall of 2009 by Brown University to facilitate advances in translational research concerned with the genetics of developmental disorders.
Brown University Herbarium	Herbarium	Dried and pressed plant specimens mounted on sheets of archival paper. Plant data. The collection includes around 100,000 plant specimens and is an important depository of Rhode Island and New England collections. It is also rich in western and southern North American plants and includes special sets of historically valuable specimens from 19th and early 20th century western US expeditions. Among other important collections, the herbarium also includes a full set of Charles Wright's Cuban plants (1856-1867) and a unique and classic collection of Carex
Brown University Oncology Group (BRUOG)	Research - Oncology Contact: Kayla Rosati, EdM, CCRP	Clinical Trials Support, Oncology Research The Brown University Oncology Research Group (BrUOG) mission is to improve cancer care through the implementation of innovative, multidisciplinary cancer clinical trials. BrUOG provides the infrastructure for the efficient development and implementation of these trials, which are created by Brown University faculty. BrUOG’s administrators and physicians provide support for the initial study concept and validation of trial design, and are responsible for trial administration, safety monitoring, data analysis, and the presentation and publication of findings. The trials sponsored by BrUOG investigate novel, cutting-edge applications of chemotherapy, biologic agents and other cancer treatments. Clinical trials are available for a broad range of disorders in hematology/oncology and these include treatment for cancers of the breast, brain, lung, gastrointestinal tract, skin, and prostate as well as trials in leukemia and lymphoma.
Brown-Lifespan Center for Digital Health	Research - Emergency Digital Health Resources	Clinical Research Resources, Emergency Digital Health EDHI’s mission is to use digital health to transform the care of patients with acute care needs before, during, and after their visit by developing and deploying effective, evidence-based digital health tools. The goal is to use technology to improve access to patients and increase the efficiency of health care delivery. As this field rapidly expands, it is critical for us to develop theoretically based interventions and to provide evidence that digital health tools are acceptable and effective, for both clinicians and patients. EDHI’s vision is for digital health to be an evidence-based, effective and well-integrated tool for creating and restoring health.
Bryant Unistructure Science Spaces	Gas Chromatograph - Mass Spectrometer (GC - MS) Contact: Christopher Reid	Agilent Technologies 7890A GC and 5975C MSD Analyze for volatile organics; pyrolysis; MSD and FID
Bryant Unistructure Science Spaces	Nuclear Magnetic Resonance (NMR) Benchtop Contact: Christopher Reid	Nanalysis Benchtop nuclear magnetic resonance (100 MHz) Analysis of organic molecules
Bryant Unistructure Science Spaces	Chromatography - Flash	Interchim-Advion Separation of organic molecules
Bryant Unistructure Science Spaces	High Performance Liquid Chromatography (HPLC) Contact: Christopher Reid	Shumatzu Analyze for non-volatile organics
Bryant Unistructure Science Spaces	Mass Spectrometer (ESI and APCI) Compact with plate express Contact: Christopher Reid	Interchim-Advion Analyze organics, biomolecules
Bryant Unistructure Science Spaces	Sample Preparation - Chromatography - Solvent Extractor Contact: Christopher Reid	Dionex ASE 350 Accelerated Solvent Extractor (ASE) Accelerated extractions
Bryant Unistructure Science Spaces	Worstation - Concentrator Contact: Christopher Reid	Caliper LifeSciences Turbo Vap LV Concentration Workstation Concentrator
Bryant Unistructure Science Spaces	Sample Preparation - Freeze Dry System Contact: Christopher Reid	Labconco FreeZone 4.5 Freeze dryer
Bryant Unistructure Science Spaces	Spectrophotometer Contact: Christopher Reid	Shimazdzu HPLC--equipped with UV/Vis and Evaporative light scattering detectors UV/Vis spectrophotometer for quantifying concentrations
Bryant Unistructure Science Spaces	Spectrophotometer Contact: Christopher Reid	Thermo Scientific AquaMate Plus UV/Vis spectrophotometer for quantifying concentrations
Bryant Unistructure Science Spaces	Microscope - Electron Contact: Christopher Reid	JEOL JSM 6010LA Scanning Electron Microscope (SEM) Scanning electron microscope with EDS
Bryant Unistructure Science Spaces	Sample Preparation - Critical Point Dryer Contact: Christopher Reid	Tousimis Sandri-PVT-3D Critical Point Dryer (CPD) Maintain structural integrity for soft tissue use of the SEM
Bryant Unistructure Science Spaces	Sample Preparation - Sputter Coater System Contact: Christopher Reid	Denton Vacuum Desk V gold sputter coater and carbon coater Coat non-conducting samples with gold or carbon for use on the SEM
Bryant Unistructure Science Spaces	Microscope Contact: Christopher Reid	Zeiss A1 AXIO Polarized Light Microscope and Q imaging RETIGA 400R Imager Recordable polarized light imaging
Bryant Unistructure Science Spaces	Microscope Contact: Christopher Reid	Zeiss Axiovert 40CFL Inverted Microscope Recordable inverted microscopy
Bryant Unistructure Science Spaces	Microscope Contact: Christopher Reid	Zeiss Primo Star with AxioCam Recordable imaging
Bryant Unistructure Science Spaces	Workstation - Anaerobic Chamber Contact: Christopher Reid	Microbiology International Whitley DG250 Anaerobic Workstation Simulate anoxic environments for anaerobic work
Bryant Unistructure Science Spaces	Workstation - Anaerobic Chamber Contact: Christopher Reid	MBRAUN Labstar Anaerobic Glovebox Workstation simulate anoxic environments for anaerobic work
Bryant Unistructure Science Spaces	PCR Thermal Cycler Contact: Christopher Reid	Bio-Rad PCR Thermocycler C1000 Touch DNA amplifier
Bryant Unistructure Science Spaces	Biological Safety Cabinet Contact: Christopher Reid	LABGARD ES class II, type A2 Biological Safety Cabinet Maintain sterility and contain infectious work
Bryant Unistructure Science Spaces	Biospecimen Banking - Freezer Contact: Christopher Reid	Thermo Scientific Isotemp Basic U86-13A41 minus 70 degree freezer Long term storage of biological specimens
Bryant Unistructure Science Spaces	Chromatography - Ion Contact: Christopher Reid	Dionex IC2100 with ED50 electrochemical detector Isocratic and gradient IC separations
Bryant Unistructure Science Spaces	PCR Thermal Cycler Contact: Christopher Reid	Bio-Rad CFX96 touch RT-PCR This real-time pcr instrument allows for up to 5-target multiplexing in sample volumes as small as 10ul. It also has a thermal gradient feature in a 96-well format.
CCRI Biology Labs	Autoclave	Consolidated Stills & Sterilizers 24D36 Sterilization. Chamber size is 24inch x36inch, Volume 9.4 cu. Ft
CCRI Biology Labs	Balance - Analytical	Orion Analytical Balance Weight determination with capacity of 60g.
CCRI Biology Labs	Balance - Top Loading	EK-I Compact Balance Weight determination (2 units)
CCRI Biology Labs	Incubator	Fisher Scientific Isotemp Digital & Analog Dry Bath Incubator Provide controlled dry heat environment for clinical & general chemistry applications
CCRI Biology Labs	Electrophoresis System	Bio-Rad Mini-Protean Tetra Cell, Vertical protein electrophoresis gel boxes Running Protein or DNA polyacrylamide gels
CCRI Biology Labs	Microscope	Lieder MI-500 Series Compound Inverted Microscope Tissue Culture
CCRI Biology Labs	pH Meter	Thermo Scientific Orion 2-Star Bench Top pH Meter General purpose measurements
CCRI Biology Labs	Western Blotting System, Semi-Dry	Shelton Scientific Semi-Dry Blotting System Transfer of protein, RNA & DNA gels to a solid membrane support for visualization, 24cmx30cm.
CCRI Biology Labs	Spectrophotometer	Thermo Scientific Genesis 20 Visible Spectrophotometer UV spectrophotometer for quantifying concentrations
CCRI Biology Labs	Imaging System - Gel Imager - Transilluminator	FOTODYNE Foto Phoresis UV Transilluminator Imaging-protein gel analysis, GFP Analysis
CCRI Biology Labs	Incubator - Shaker	Lab Companion IS-971 Floor Model Incubator Shaker Growing of bacteria, 250 L chamber
CCRI Biology Labs	Biological Safety Cabinet	NuAire Class II Type A2 Maintain sterility and contain infectious work
Cell Analysis and Sorting Core	Flow Cytometer Contact: Alan Rothman	Miltenyi MACSQuant-10 Analytical Flow Cytometer Analytical flow cytometry- 3 lasers, 10 parameters (8 colors, FSC, SSC)
Cell Analysis and Sorting Core	Microplate Reader Contact: Alan Rothman	BioTek Cytation 3 Imaging plate reader; 5 colors (brightfield, GFP, RFP, DAPI, Cy5); 10x, 20x, 60x objectives
Cell Analysis and Sorting Core	Microscope Contact: Alan Rothman	Life Technologies Evos FL, Fluorescence Microscope Fluorescence microscope; 4 colors (GFP, RFP, DAPI, Cy5); 10x, 40x, 100x objectives
Cell Analysis and Sorting Core	Cell Sorter - Magnetic-Activated Cell Sorter (MACS) Contact: Alan Rothman	Miltenyi AutoMACS Automated cell sorter for cell suspensions labeled with magnetic beads.
Cell Analysis and Sorting Core	Microplate Reader Contact: Alan Rothman	Perkin-Elmer Envision Multimodal plate reader- absorbance, luminescence, fluorescence, time-resolved fluorescence, AlphaScreen
Cell Analysis and Sorting Core	Flow Cytometer Contact: Alan Rothman	BD LSRII Flow Cytometer Analytical flow cytometric analysis; 4 lasers (blue (2), violet (4), red (3) and yellow green (5)) which allows for analysis of up to 14 different fluors (# listed in parentheses for each laser)
Center for AIDS Research (CFAR) - Providence/Boston	Research - BioBehavioral Research Support, HIV Contact: Curt Beckwith BioBehavioral Sciences Webpage	Clinical Research Service, HIV Research The BioBehavioral Sciences Core (BBSC) provides help with participant recruitment, enrollment, and retention to advance biobehavioral research; services to support innovative medical and behavioral data collection approaches, including methods, tools, and assessments; expertise and services related to regulatory and human subjects’ compliance, and the ethical conduct of research for vulnerable populations; provide expertise and services to support the development, implementation, and evaluation of interventions to improve HIV prevention and continuum of care outcomes; specialized services for the conduct of implementation science research and for performing cost-effectiveness research; PrEP related services and information; and guidance and support for accessing EMR data.
Center for AIDS Research (CFAR) - Providence/Boston	Research - Biostatistics, HIV Contact: Joseph Hogan, ScD Biostatistics Webpage	Clinical Research Service, HIV Research The Biostatistics Core ensures that all research undertaken by Center for AIDS Research (CFAR) investigators uses optimal methods for study design and analysis. The Core provides guidance and collaboration in developing grant applications; collaboration on study design, conduct, and statistical analyses; statistical training and mentoring; facilitation of linkages to potential collaborators; provides guidance and support for accessing EMR data; facilitates access to HIV databases from other centers/programs, and develops novel statistical and epidemiological methods for HIV research.
Center for AIDS Research (CFAR) - Providence/Boston	Research - Substance Use Research Core, HIV Contact: Christopher Kahler, PhD Substance Use Research Core Webpage	Clinical Research Service, HIV Research The Substance Use Research Core (SURC) offers services and expertise on the methods needed to conduct effective Substance Use (SU)/HIV research. The SURC offers expertise in innovative methods for assessing and analyzing SU, and developing and implementing interventions to address alcohol, tobacco, and other drug use. Services include: expertise in developing research projects that address gaps in SU/HIV priority issues both domestically and globally; advice on training on the most appropriate methods for assessing SU; advice and training on incorporating effective and up-to-date SU interventions; and guidance on addressing ethical issues with SU research including input on IRB protocols and human subject sections of grant applications and access to group trainings.
Center for AIDS Research (CFAR) - Providence/Boston	Administration - CFAr Contact: Vicki C. Godleski Administrative Core Webpage	Clinical Research Service, CFAR Coordinating Center The CFAR Administrative Core has built an HIV infrastructure across the partner institutions and provides oversight of the entire CFAR community with responsibility for sound management, organizational structure, appropriate resource allocation, evaluation and the promotion of inter/multi-disciplinary translational HIV research. Through efficient communication to CFAR membership, the Core manages a highly interactive and collaborative scientific environment across geographically dispersed settings in domestic, national and international sites.
Center for AIDS Research (CFAR) - Providence/Boston	Research - Basic Sciences, HIV research Contact: Rami Kantor, MD Basic and Translational Sciences Webpage	Clinical Research Service, HIV Research The Basic Sciences Core builds and supports collaborative research and synergy between basic, translational clinical and behavioral investigators as well as other multidisciplinary scientists, by providing laboratory, consultation and mentoring services. Services include; Viral load measurement, STI testing, Genital tract specific assays, Biologic specimens collection techniques, HIV-1 and 2 drug resistance assays, Identification of HIV dependency factors (HDF), Cell culture, Viral stocks, Immune activation, Laboratory Consulting, Training and Mentoring. Additional assays may be developed as necessary, please contact the Core Director.
Clinical Pharmacokinetics Research Laboratory	Pharmacokinetics Consultation Contact: Fatemeh Akhlaghi	Clinical Research Resources, Pharmakokinetics The laboratory is capable of providing support for the design and implementation of pre-clinical and clinical pharmacokinetics studies as well as design and conduct of ancillary in vitro studies (protein binding and microsomal incubations to characterize phase 1 or 2 metabolism). With extensive background in pharmacokinetics modeling and simulation using NONMEM, WinNonlin and Simcyp softwares, the laboratory can provide a valuable resource for on-going or completed clinical studies. Additional data analysis capabilities includes in-vitro in-vivo correlation (IVIVC) and bioequivalence analysis.
Clinical Pharmacokinetics Research Laboratory	Pharmacokinetics, Bioanalytical support Contact: Fatemeh Akhlaghi	Clinical Research Resources, Pharmakokinetics The Clinical Pharmacokinetics Research Laboratory is equipped with two UPLC-MS/MS and one quadrupole-time-of-flight mass spectrometer (ESI-QTOFMS) systems capable of measuring the concentration of small molecule xenobiotics and their metabolites as well as endogenous or therapeutic peptides and proteins. To date, this laboratory has developed various assays for the quantification of up to 60 different compounds and validated these assays according to guidelines by the Food and Drug Administration of the United States. The laboratory is proficient in providing analytical support for on-going pre-clinical and clinical studies and during different stages of a drug development project.
Clinical Research and Development Service	Research - Clinical Research and Development Service Resources	Clinical Research Resources, Veteran Population The VA Research's fundamental mission is to advance the healthcare of Veterans. The Providence VA Medical Center has a large funded research and development program, including studies in Rehabilitation Medicine, Cardiology, Mental Health, Neuroscience, Substance Abuse, Health Services & Economics, and Pulmonary Disease. These studies enhance our ability to provide state-of-the-art techniques and treatments to our patients. At the same time, the research program helps Providence VAMC recruit and retain the highest quality health care professionals who treat our Veterans in the VA Clinics on a daily basis.
Computational Biology Core (CBC)	Analysis - Data Analysis Contact: CBC help	Service The core provides assistance in experimental design and data processing pipelines for high-throughput datasets generated in individual projects, particularly for DNA/RNA sequencing data.
Computational Biology Core (CBC)	Analysis - Standardized Data	Service Develop/Implement Bioinformatic Pipelines; GATK whole exome, Cut and run. Develop/Implement Standardized QC for Workflows. Experimental Design Support; Power Analysis for Microbiome and RNAseq. Exploratory Data Analysis; RNAseq, scRNA seq.
Computational Biology Core (CBC)	Toolingqckitfastq	Software - R-Qckit A comprehensive quality control R package for Next Generation Sequencing FASTQ data.
Computational Biology Core (CBC)	ToolingRSeqAn	Software - RSeqAn Wrappers for the SeqAn library for use in R with Rcpp
Computational Biology Core (CBC)	Toolingbioflows	Software - Bioflows A bioinformatics workflow engine that streamlines the most common analysis pipelines. Key features include: 1) Provision of standardized workflows 2) A module for automating SRA downloads and 3) External tools are made available as CONDA packages along with the tool.
Computational Biology Core (CBC)	Tooling	Software - Scripts Access Genbank, BioCookBook.jl
Computational Biology Core (CBC)	ToolingNMRdock	Containerization with Docker - NMRDock NMRdock is a Docker container image for processing raw NMR time domain data into frequency domain spectra and analyzing the spectra. The image includes NMRPipe and NMRFAM-Sparky for processing and analysis, respectively. NMRdock can be installed on any operating system (OSX, Windows, or Linux) and has the full functionality of both NMRPipe and NMRFAM-Sparky. For guides on processing BioNMR data in NMRdock, please access our Walkthrough Section
Computational Biology Core (CBC)	Tooling	Containerization with Docker IDeP
Computational Biology Core (CBC)	ToolingIngenuity Pathway Analysis	Software- Ingenuity Pathway Analysis The CBC provides access to the Ingenuity Pathway Analysis web server at Brown University.
Computational Biology Core (CBC)	Analysis - Data Analysis	Service The CBC now allows for a very restricted schedule of Fee-For-Service project.
Computational Biology Core (CBC)	Data Management RefChef	CCV - RefChef RefChef is a reference management tool used to: (1) document the exact steps undertaken in the retrieval of genomic references; (2) maintain the associated metadata; (3) provide a mechanism for automatically reproducing retrieval and creation of an exact copy of genomic references.
Computational Biology Core (CBC)	Training and SupportWorkshops	Service Workshops
Computational Biology Core (CBC)	Training and Support	Service - Consulting The Core provides two distinct complimentary services to all researchers at Brown. Appointment Based, A team of experienced computational biologists and biostatisticians are on-hand to help investigators design experiments. Weekly Consulting Sessions, The Core offers two hours walk-in Consulting sessions for all researchers to discuss any immediate issues in data analysis including trouble-shooting code, help with statistical analysis and discussion of options for bioinformatic analysis.
Computational Biology Core (CBC)	Training and Support	Service -Talent Development Student worker/interns, Guidance and mentoring
Computational Biology Core (CBC)	Training and SupportOutreach	Service - Outreach CBC hosts workshops, publishes tutorials on computing tools used by bioinformaticians, and provides analysis support to the Brown community.
CyTOF Core (Legorreta Cancer Center at Brown University)	Training and Technical Assistance	Service Advise investigators with experimental design, implementation and data analysis. Provide support for grant submissions.
Design and Analysis Core	Design - Experimental Design	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Multilevel and Hierarchical Modeling	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Machine Learning	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Feature Extraction	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Effective and Functional Connectivity	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Spatial-Temporal Modeling	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Time Series Modeling	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	General Linear Model (GLM) and Linear Model (LM)	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Analysis of Variance (ANOVA)	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Regression for High Dimensional Data	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Analysis - Network Analysis	Clinical Research Resources, Behavior and Neuroimaging
Design and Analysis Core	Causal Interference	Clinical Research Resources, Behavior and Neuroimaging
Diagnostic Imaging Research	Research - Diagnostic Imaging Research Resources	Clinical Trials Support, Diagnostic Imaging The Division of Imaging Research has successfully completed both federally-funded and industry-sponsored research trials. The Division has participated in cancer imaging trials that include screening studies and studies looking at the efficacy of various imaging modalities.The Division has participated in studies with pharmaceutical companies on phase I, II, and III trials. These studies include both diagnostic and cancer treatment drugs. We have also worked with various device manufacturers that are seeking pre-market and post-market Food and Drug Administration approval for medical devices. In addition, the Division has participated in several blood biomarker studies.
Drosophila Media Facility	Drosophila Media Preparation	Service The Drosophila Media Facility is dedicated to providing investigators with high quality media for Drosophila research. In the centralized kitchen, a standard cornmeal, sucrose, yeast medium is prepared and dispensed into different sized culture vessels. Media is prepared according to a strict protocol that ensures consistency in diet and the absence of any bacterial, fungal or insect contamination. Researchers using glass vials return them to the facility where they are autoclaved, washed, and filled again. This centralized kitchen is equipped with a food-service quality Cleveland Range Kettle MKET-12-T. Media is pumped into trays of vials or plastic bottles using a Gilson Fly Food Dispenser. Used glass vials are returned to the facility where they are sterilized in a Steris autoclave and washed in a Northwestern Systems G403 electric heat glassware washer.
Drug Discovery Core (Legorreta Cancer Center at Brown University)	Training and Technical Assistance	Service Advise interested investigators on cancer drug screens, cell-based assay development, assay optimization, and use of various chemical libraries/FDA-approved drugs to support research in the area of drug discovery and development. Advise on target validation, and interface with medicinal chemistry. Provide technical support for screening implementation, library plating, high-throughput robotic screening, and advice on prioritization of hits. Provide support for grant submissions.
Electron Microprobe Facility	Analyzer - Electron Microprobe Contact: Stephen Parman	Cameca SX100 Electron Microprobe Analyzer The Cameca SX-100 electron microprobe is equipped with 5 wavelength dispersive spectrometers (WDS) and a Rontec energy dispersive spectrometer (EDS).The WDS spectrometers each contain two or four diffracting crystals and presently include LTAP, TAP (2), LPET (2), PET, LLIF (2), LIF, LPCO, PC1 and PC2. The last three crystals are used to measure the light elements (boron to sodium). The absolute detection limits for the instrument are approximately 50-200 ppm, depending on the element. The EDS spectrometer is capable of detecting all elements above sodium (Na). X-ray element maps can easily be acquired on the microprobe. Using 512x512 pixel maps, up to nine element maps (5 elements on WDS, 4 with EDS), plus a backscattered electron (BSE) image, can be obtained simultaneously. Maximum resolution on any one map is one micron per pixel. Utilizing the coordinate system, maps of entire thin sections can be generated.
Electron Microscopy Facility	Microscope - Focused Ion Beam Electron (FIB)	Thermo/FEI Helios Dual Beam Focused Ion Beam Electron Microscope (FIB) with an Omniprobe nanomanipulator and autoTEM sample preparation The FIB is fully equipped for (near) simultaneous ion/electron beam imaging and patterning of specimens. A Pt metal deposition source is available for ion (or electron) beam assisted deposition of conducting lines. A second source is available to enhance the carbon removal rate. An Omniprobe AutoProbe 200.2 allows the physical manipulation of samples with nanometer precision and is used along with Pt metal deposition and standard FIB trenching to allow the selection and removal of electron transparent TEM samples from specific microstructural features. A NPGS pattern generation system (plus beam blanker and external scan interface) controls the electron beam for high resolution, interlaced pattern generation used in the FIB fabrication of nanostructures. Three dimensional crystallographic data can be generated from specimens using the fully automated EBSD system (Oxford HKL&EBS-3). The microscope is also equipped with an EDS detector for elemental analysis. An electron flood gun can be used with the ion beam to image/etch nonconductive samples. A low temperature holder is available for beam sensitive samples.
Electron Microscopy Facility	Microscope - Scanning Electron (SEM)	LEO 1530 High Resolution Scanning Electron Microscope (HRSEM) The LEO 1530 VP ultra-high resolution field emitter SEM that allows for a resolution of 1 nm at a voltage of 20 kV in high vacuum and 2 nm at 30 kV in the variable pressure mode. It is fully equipped with EDS for chemical mapping and includes a Debbem tensile test stage 5kn. The instrument is equipped with Nabity pattern generating software a high speed beam blanker and is set-up for high resolution electron-beam lithography. The LEO 1530 VP is capable of a resolution of 2.1 nm at very low electron energies (1 kV) which is of great use for beam-sensitive materials like polymers and insulating surfaces. Also very useful for insulating samples is the variable operating pressure mode which allows insulating materials to be imaged without coating the surface.
Electron Microscopy Facility	Microscope - Transmission Electron (TEM)	FEI CM20 TEM The FEI CM20 is available for applications that require high tilt, moderate resolution (0.23 nm). This 200 kV analytical TEM allows the large specimen tilts needed for dislocation characterization and weak-beam imaging applications. It is equipped with a low background double tilt holder and a liquid nitrogen temperature holder. Compositional analysis is performed on this instrument using energy dispersive x-ray spectroscopy. Images are recorded using a large field of view, side mounted, digital image acquisition system.
Electron Microscopy Facility	Microscope - Scanning Transmission Electron Microscope -S(TEM)	JEOL 2100F - S (TEM) The 2100F is a 200 kV, field emission source, high-resolution/analytical S(TEM) capable of 0.10 nm lattice resolution. It is primarily used for obtaining lattice images or when chemical or crystallographic information is required from laterally small areas (1-10 nm). The instrument is equipped with an x-ray spectrometer capable of light element detection, a Gatan image filter (GIF) for element and phase analyses and enegy filtered imaging, a high tilt holder for electron tomography and a high-resolution CCD camera system for digital image acquisition and processing. A low background double-tilt holder for chemical analysis by EDS, a standard double tilt holder, a heating holder capable of 1000C, and a heating straining holder are available. Probes as small as 1 nm in diameter are accessible for micro-diffraction experiments. STEM mode for EDS line and area scans, bright and dark field STEM detectors, and high angle annular dark field is capable in STEM mode.
Electron Microscopy Facility	Spectrometer - ThermoElectron K-Alpha XPS	Thermo/FEI K-Alpha X-Ray Photoelectron Spectrometer This equipment is used to study the surface composition of materials using photoelectrons generated by 30 kV monochromated Aluminum K-Alpha x-rays hitting the sample. It is equipped with an Argon sputter gun for surface cleaning and depth profiling. There is a tilt and rotate holder. There is a transfer holder so samples can be transferred to the XPS with exposure to atmosphere.
Electron Microscopy Facility	Microscope - Quattro S-E(SEM)	Thermo/FEI Quattro S-E(SEM) The Quattro is an environmental SEM which means that the sample chamber can be set to a (relatively) high pressure for water containing samples.Â This SEM has EDS (X-ray detection) and EBSD (electron backscatter). The Quattro S is a field emission scanning electron microscope capable of generating and collecting all available information from any type of sample material. It provides the most versatile high-resolution low-vacuum FEG SEM with extended low-vacuum capabilities and the most versatile high resolution SEM for characterization, prototyping and in situ analysis. The features include three vacuum modes enabling investigation of conductive, non-conductive and high-vacuum incompatible materials such as High-vacuum mode (<6*10-4 Pa) for imaging and microanalysis of conductive and/or conventionally prepared specimens; Low-vacuum mode (10 to 130 Pa) for imaging and microanalysis of non-conductive specimens without preparation; and ESEMâ„¢ mode (10 to 4000 Pa) for high-vacuum incompatible specimens which are impossible to investigate with traditional EM methods. The system is equipped with a 5-axes motorized x-y-z-tilt-rotate stage,for Sample navigation.
Electron Microscopy Facility	Sample Preparation	Electron Microscope Facility Sample Preperation Area Tools available in the EMF sample preparation area include a jet polisher, polishing benches, dimpler and high and low speed diamond saws.The sample prep area has a carbon thread evaporator and Gold/Palladium sputter coater for making conductive coatings on SEM samples. There is an ion mill (PIPS) for making TEM samples. There is also a plasma cleaner for TEM sample holders and SEM samples.
Emergency Medicine Research Laboratory	Research - Emergency Medicine Research Laboratory Resources Contact: Francesca Beaudoin	Clinical Trials Support, Emergency Medicine The research program in the Department of Emergency was established to support investigator-initiated research and pharmaceutical, biologic and biomedical device trials. The program is supported by a Research Program Administrator, two pre-award Research Administrators, a Clinical Research Supervisor, and a staff of Clinical Research Assistants. The department maintains clinical research space within emergency departments as well as fully-equipped basic science laboratories, and has ongoing collaborations with Brown University and other hospital departments.The main focus areas of the Department of Emergency Medicine research program are (1) injury prevention and control, (2) cardiovascular, neurologic, and resuscitation science, (3) pediatric, age, and gender specific care, and (4) healthcare systems science.
Environmental Chemistry Facility	Analyzer - Discrete Analyzer	Westco Smartchem 200 Used to determine Nitrate/Nitrite, Phosphate, Ammonia, Silicate, and other nutrient concentrations in water samples and soil extracts.
Environmental Chemistry Facility	Analyzer - Elemental Analyzer	Thermo Scientific, FlashSmart EA Analysis of carbon, nitrogen, and sulfur concentration of solid samples
Environmental Chemistry Facility	Analyzer - Inorganic Carbon Analyzer	UIC, INC Inorganic Carbon Analyzer Measures total inorganic carbon by automated acidification and coulometric detection in a wide variety of sample matrices. Solid samples ranging from low ppm to 100% inorganic carbon can be analyzed with this system.
Environmental Chemistry Facility	Analyzer - Mercury Analyzer	Milestone DMA-80 Direct Mercury Analyzer Determines mercury content of solid and liquid samples.
Environmental Chemistry Facility	Analyzer - Water Isotope	Picarro L1102-I Measures delta deuterium/hydrogen (D/H) ratio and delta 18O/16O in liquid water
Environmental Chemistry Facility	Sample Preparation - Freeze Dry System	Labconco FreeZone 6 Liter For removing water and other solvents from frozen samples by sublimation.
Environmental Chemistry Facility	Liquid Chromatography System	Dionex DX500 Ion chromatography analysis of anions and cations in marine and freshwater samples
Environmental Chemistry Facility	Sample Preparation - Microwave Digestion System	Milestone Ultrawave Used to digest solid samples (soils, sediments, rocks, plants, tissues), for elemental analysis.
Environmental Chemistry Facility	Spectrometer - Atomic Absorption Spectrometer-Graphite Furnace (GFAAS)	Perkin Elmer AAnalyst 600 Graphite Furnace This spectrometer is useful for measuring trace levels of metals in water and soil.
Environmental Chemistry Facility	Spectrometer - Inductively Coupled Plasma Optical Emission Spectrometer (ICP-OES)	Thermo Scientific iCAP 7400 DUO ICP-OES Analysis of most elements with atomic weights above 10.
Environmental Chemistry Facility	X-Ray Fluorescence - Handheld	Innov-X Systems Alpha 4000 Handheld Non-destructive elemental analysis on a variety sample types for concentrations of some metals ranging from about 20 ppm to 10%.
Environmental Chemistry Facility	X-Ray Fluorescence - Handheld	Olympus Delta Professional Handheld Non-destructive elemental analysis on a variety sample types for concentrations of elements greater than 10 ppm.
Environmental Chemistry Facility	Liquid Chromatography - Mass Spectrometer	Agilent 1200 LC/MS System Used to separate and then quantify the chemical components in a given sample.
Environmental Chemistry Facility	Gas Chromatography - Flame Ionization Detector	Agilent 7090B GC-FID Used to measure the trace levels of semivolatile organic compounds in a given organic extracted sample.
Environmental Chemistry Facility	Gas Chromatography - Mass Spectrometer	Agilent 5977B GC-MSD Used to determine molecular composition and the concentration of organic compounds in organic extracted samples
Environmental Chemistry Facility	Mass Spectrometer - Isotope Ratio Mass Spectrometer	Thermo Scientific GC/EA-C-IRMS Delta V Plus GC: Used primarily for compound specific ð D in organic extracts; EA: Used for bulk organic ð13C and ð15N in solid samples.
Environmental Chemistry Facility	Mass Spectrometer - Isotope Ratio Mass Spectrometer	Thermo Scientific GC-C-IRMS Delta V Plus Used primarily for compound specific ð13C in organic extracts
Environmental Chemistry Facility	Accelerated Solvent Extractor (ASE)	ASE 200 Dionex Used to extract organic compounds from solid samples.
Extracellular Vesicle Core	Centrifuge - Ultra	Thermo Fisher WX80 ultracentrifuge Ultracentrifugation is the classical method for extracellular vesicles isolation. The Extracellular Vesicle Core contains two Thermo Fisher WX80 ultracentrifuges with Sorvall AH-629 rotors.
Extracellular Vesicle Core	PCR Thermal Cycler	ViiA 7 real-time PCR system with twister robot We identify extracellular vesicles MicroRNA/mRNA profiling using the ABI TaqMan PCR array by ViiA 7 Real-Time PCR System, which is fully compatible with any standard or fast-cycling 384- or 96-well plates and TaqMan Array Micro Fluidic Cards and allows quickly and efficiently look up to 348 unique microRNAs/mRNAs per sample with as little as 1ng of input total RNA with pre-amplification.
Extracellular Vesicle Core	Analyzer - Nanoparticle Counter	NanoSight 5000 Nanoparticle Counter Nanoparticle tracking analysis (NTA) – direct and real-time visualization and analysis of nanoparticles in liquids, and calculate the size, size distribution and concentration of the particles. Brownian motion of nanoparticles is analyzed using the Stokes-Einstein equation.
Extracellular Vesicle Core	Ultrafiltration	TangenX By using tangential flow filtration (TFF) technology, TangenX delivers rapid and highly efficient isolation of extracellular vesicles from large volumes of samples.
Flow Cytometry and Sorting Facility	Fluorescence Activated Cell Sorter (FACS)	Becton Dickinson (BD) Biosciences FACS Aria III Cell counting, sorting, biomarker detection. The FACSAria has five air-cooled lasers at 351nm, 488nm, 561nm, 633nm, and 407nm allowing multicolor analysis of up to 20 parameters. It can sort 1 to 4 populations simultaneously and is equipped with an Automated Cell Deposition Unit, an Aerosol Management System and a refrigeration system. It can accept various sample input tubes including 1 mL microtubes, 12 x 75-mm test tubes, and 15 mL tubes into the sample and collection chambers.
Flow Cytometry and Sorting Facility	Flow Cytometer - Benchtop AnalyzerCytek Info	Cytek Aurora The Cytek Aurora can analyze similar and very similar spectral emitting fluorochromes. Instead of analyzing small chunks of fluorescence and calculating fluorescence spill over, the Cytek Aurora looks at the full spectrum emitence of each fluorochrome. This allows colors that would normally be unusable with each other to be run in tandem. The Cytek Aurora can analyze up to 38 fluorochromes, 41 parameters (FSC, 488 SSC, 405 SSC).
Flow Cytometry and Sorting Facility	Fluorescence Acticated Cell Sorter (FACS)	Becton Dickinson (BD) Biosciences FACS Celesta Cell counting, biomarker detection. The FACSCelesta has three air-cooled lasers at 488nm, 561nm and 407nm allowing multicolor analysis of up to 15 parameters that has an attached high throughput system (HTS) that allows users to analyze samples directly from a 96 well plate.
Flow Cytometry Core - Rhode Island Hospital	Fluorescence Activated Cell Sorter (FACS)	Becton Dickinson (BD) Biosciences LSRII Analyzer/Flow Cytometer Digital, 4 laser (355nm, 405nm, 488nm and 635nm) flow cytometric analysis system with 10 fluorescent channels plus 2 scatter channels. BD FACSDiva software with digital compensation and ModFit software for cell cycle analysis.
Flow Cytometry Core - Rhode Island Hospital	Mass CytometryLegorreta Cancer Center	Fluidigm Helios (CyTOF) Mass Cytometry Mass cytometry combines the technologies of flow cytometry with that of mass spectrometry. It applies nebulization, aerosolization and ionization to cells labeled with heavy metal isotope-conjugates, allowing for ion separation based on their mass:charge ratio and quantification of each isotope on a per cell basis ultimately determining properties of a cell population at a single-cell resolution. The technique of mass cytometry is powerful, as it can analyze more cellular targets without the problem of compensation as seen in flow cytometry. The Helios is capable of simultaneously analyzing up to more than 50 parameters both on cell surface and intracellularly.
Flow Cytometry Core - Rhode Island Hospital	Fluorescence Activated Cell Sorter (FACS)	Becton Dickinson (BD) Biosciences Influx Cell Sorter 5 laser system (355nm, 405nm, 488nm, 561nm and 638nm) for simultaneous detection of up to 14 parameters. Sorts up to 4 different cell populations. Capable of single cell deposition into many different sized culture plates (96 or 384 well plates, etc). Equipped with a small particle objective for FSC size determination down to 0.5 micrometers. Enclosed in a biosafety hood. The sorter separates particles on the detection of fluorescent markers on particles such as cells, chromosomes, bacteria or nuclei. Then the collected cells are suitable for downstream analysis either in molecular applications like protein assays and PCR, or used in viable assays such as tissue culture or injected into in vivo models. Generated data may also be used to determine percentages of interrogated populations. The sorter can separate populations into tubes (1.5ml, 4ml, 15ml, 50ml), multi-well plates (6, 24, 48, 96, 384), or directly onto microscope slides.
Flow Cytometry Core - Rhode Island Hospital	Training and Technical Assistance	Service
Genomics Facility - Brown	Bioanalyzer	Agilent Bioanalyzer 2100 Microfluidics-based platform for sizing, quantification and quality control of DNA, RNA.
Genomics Facility - Brown	Analyzer - Fragment	Advanced Analytical, Fragment Analyzer Capillary Electrophoresis - Analyze DNA fragments for Next-Gen Sequencing, genotyping, checking RNA quality and quantity, and working with microsatellite simple sequence repeats (SSRs).
Genomics Facility - Brown	Cell Counter	Life Technologies Automated Countess Cell Counter Measure cell count and viability (live, dead, and total cells) using the standard trypan blue technique.
Genomics Facility - Brown	Centrifuge	Sorvall Legend T Benchtop Low to medium speed centrifugation
Genomics Facility - Brown	Centrifuge - Ultra	Beckman Coulter Optima Max UltraCentrifuge High speed centrifugation with MLA130, TLA110 & TLA100 Rotors
Genomics Facility - Brown	Disrupter	Covaris S220 High Performance Ultrasonicator DNA, RNA, and chromatin shearing, tissue homogenization, cell lysis, compound dissolution, and particle micronization
Genomics Facility - Brown	Imaging System - Gel Imager	LI-COR Odyssey Clx IR (Infrared) Imaging System Western blot analysis, EMSA, protein arrays, In-Cell Western Assays, On-Cell Westerns, in vivo imaging, Coomassie gel documentation, DNA gel documentation, and tissue section analysis.
Genomics Facility - Brown	Microarray Platform	Affymetrix Gene Chip Instrument System A fully integrated platform for Affymetrix microarrays
Genomics Facility - Brown	Microarray Scanner	Molecular Devices GenePix Scanner 4000B Two color microarray scanner
Genomics Facility - Brown	PCR Thermal Cycler	Applied Biosystems ViiA 7 Real-Time PCR System Medium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput
Genomics Facility - Brown	PCR Thermal Cycler	Applied Biosystems ViiA 7 Real-Time PCR System Medium to high throughput 96- and 384-well fast real time quantitative PCR formats, medium to high throughput
Genomics Facility - Brown	Spectrophotometer	Thermo Scientific Nanodrop One A microvolume spectrophotometer for measuring DNA and RNA.
Genomics Facility - Brown	Technical Assistance - Affmetrix Microarray	Service Service to provide Affymetrix gene expression array service
Genomics Facility - Brown	Technical Assistance - NGS Library Quality Control	Service Analysis of library size distribution and qPCR quantification
Genomics Facility - Brown	Analyzer - nCounter Systems	NanoString - nCounter Sprint Profiler Molecular barcoding technology for RNA, DNA, and protein profiling applications. Digitally examine multiple pathways in a single tube in an extraction-free workflow. Included nSolver Analysis Software. Compatible with FFPE tissue. Highly multiplexed analysis of many functional pathways such as among others cancer, inflammation, cell death and custom designed expression analysis. Operated as fee for service.
Genomics Facility - Brown	Imager and Microplate Reader	BioTek Cytation 5 Cell Imaging Multi-Mode Reader UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence. Cell migration and invasion assays, Live cell imaging, Fluorescence cell imaging (DAPI & GFP), Multi-mode reader applications, Immunofluorescence, Phenotypic assays, Histology
Genomics Facility - Brown	PCR Thermal Cycler - Droplet Digital	Bio-Rad QX200 Droplet Digital (ddPCR) PCR System Provides absolute quantification of target DNA or RNA molecules for EvaGreen or probe-based digital PCR applications.
Genomics Facility - Brown	DNA Sequencer	Illumina - NextSeq550 The NextSeq550 Next Generation Sequencing system is a high throughput bench top sequencer that provides accurate fast sequencing data, and by employing flexible run configurations it can be easily adopted to a researcher’s needs depending on their required read length and sequencing depth. Reagents are available in a mid-output and a high output mode resulting in maximum cluster numbers of 400 million (high output) and 130 million (mid output) clusters (reads).
Genomics Facility - Brown	Microplate Reader	BioTek Synergy H1 Hybrid Multimode (H1MM) Microplate Reader UV-Vis absorbance, Fluorescence intensity, Luminescence, Fluorescence polarization, Time-resolved fluorescence. Cell based assays, Biomarker assays, Micro-volume analysis of nucleic acid and protein, Kinetic assays.
Genomics Laboratory - Providence VA Medical Center	Autoclave	Tuttnauer Equipment: consumable sterilization
Genomics Laboratory - Providence VA Medical Center	Bioanalyzer	Agilent Bioanalyzer DNA size & quantification (quality check for downstream analyses, i.e. next gen sequencing)
Genomics Laboratory - Providence VA Medical Center	Analyzer - Genetic	Applied Biosystems 3500 Genetic Analyzer Capillary Electrophoresis - Analyze fragment length polymorphisms (96 format) (2)
Genomics Laboratory - Providence VA Medical Center	Centrifuge	Eppendorf Refrigerated Centrifuge Alcohol precipitation
Genomics Laboratory - Providence VA Medical Center	Centrifuge	Eppendorf For centrifuging 96/384 plates
Genomics Laboratory - Providence VA Medical Center	DNA Sequencer	Ion Gene Studio/S5 with Ion Chef/ThermoFisher Next Generation Sequencer
Genomics Laboratory - Providence VA Medical Center	Mass Spectrometer	Sequenom high throughput SNP genotyping, epigenetics
Genomics Laboratory - Providence VA Medical Center	Microarray Scanner	Illumina iScan Whole-genome genotyping, gene expression analysis, methylation analysis
Genomics Laboratory - Providence VA Medical Center	Microplate Reader	BioTek DNA quantification
Genomics Laboratory - Providence VA Medical Center	Microplate Reader	Fluidigm End Point Reader High throughput SNP genotyping
Genomics Laboratory - Providence VA Medical Center	PCR Thermal Cycler	Applied Biosystems 384 well DNA amplification for downstream analysis (i.e. sequenom processes) (2 units)
Genomics Laboratory - Providence VA Medical Center	PCR Thermal Cycler	Applied Biosystems 96 well DNA amplification for downstream analysis (i.e. fragment length polymorphisms)(2 units)
Genomics Laboratory - Providence VA Medical Center	Robotic Workstation - DNA Extraction	Chemagen/Perkin Elmer Magnetic Separation Module DNA extraction from blood & saliva
Genomics Laboratory - Providence VA Medical Center	Robotic Workstation - Liquid Handler	Sequenom Liquid Handler Transfers PCR chemistries to samples (96/384 format)
Genomics Laboratory - Providence VA Medical Center	Robotic Workstation - Liquid Handler	Sequenom Nanodispenser Dispenses PCR product to Sequenom chip
Genomics Laboratory - Providence VA Medical Center	Robotic Workstation - Sample Preparation	Iontorrent/Life Technologies Enrichment System Simplifies the workflows for the Ion PGM system by providing an automated solution for scalable and reproducible template preparation.
Genomics Laboratory - Providence VA Medical Center	Robotic Workstation - Sample Processing	Thermo Scientific Cap-it-All Caps tubes to the optimal torque to maintain sample integrity and provide a hands free method to capping and decapping tubes quickly and easily.
Genomics Laboratory - Providence VA Medical Center	Robotic Workstation -Liquid Handler	Beckman Coulter Lab Automation Workstation Automated liquid handler
Genomics Laboratory - Providence VA Medical Center	Spectrophotometer	Thermo Scientific NanoDrop DNA quantification
Genomics Laboratory - Providence VA Medical Center	DNA Sequencer Contact: Kayla Dwyer	Qiagen Pyromark Q96 ID Quantitative analysis of genetic/epigenetic DNA modifications using Pyrosequencing technology
Genomics Laboratory - Providence VA Medical Center	PCR Thermal Cycler	Applied Biosystems Real Time PCR Quant Studio 12K Flex Analyze single nucleotide polymorphisms (single locus) (96/384 format)
Genomics Laboratory - Providence VA Medical Center	Robotic Workstation-Sample Preparation	Tecan Freedom Evo Simplifies the workflows for the Illumina HiScan system by providing an automated solution for scalable and reproducible sample preparation.
IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE)	IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE) Contact: CADRE	Clinical Research Resources, Addiction & Disease Established in 2019, the Center for Addiction and Disease Risk Exacerbation (CADRE), is a federally funded NIH Center of Biomedical Research Excellence (COBRE). Through its affiliation with the Center for Alcohol and Addiction Studies at the Brown University School of Public Health, CADRE is investigating mechanisms whereby substance use impacts disease, using multi-disciplinary methods, including behavioral and physiological laboratory-based approaches across several substances of abuse.
IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE)	Analyzer - Automated Immunoassay System Contact: CADRE	ProteinSimple - Ella Next Generation ELISA system The Ella mutiplex analyzer allows for multi-plexing of multiple biomarkers on the same cartridge. Rather than performing a separate ELISA for each biomarker with more sample volume to run in triplicate, the ELLA can multi-plex biomarkers in triplicate within a single well, increasing the amount of data that can be generated from clinical samples.
IDeA COBRE Center for Addiction & Disease Risk Exacerbation (CADRE)	Clinical Laboratory Core Contact: CADRE	Service The CADRE Clinical Laboratory Core (CLC) is a 'one-stop shopping' resource for clinical laboratory investigators. We provide laboratory space, supplies, equipment, research nursing capability, biomarker processing capability, scientific expertise and data management/analysis expertise. Provision of these resources via the CLC improves efficiency, consistency and economy of scale across projects.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Analyzer - Cell Metabolism	Seahorse Biosciences - XF Extracellular Flux Analyzer XF instruments analyze mitochondrial respiration and glycolysis in live cells, generating data in just minutes. XF Technology uses solid-state sensors to simultaneously measure both oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in every well. All platforms support injection of up to 4 unique compounds per well.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Sensing equipment - Electrical Cell Impedance Sensing (ECIS)	Applied BioPhysics, Model 100 and Model ECIS Z Theta Measures cell impedance using altering currents across cell monolayers and measuring the change in electrical potential. Impedance is calculated using Ohm's law.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Behavioral Phenotyping - Hypoxia Chamber	BioSpherix Rodent Hypoxia Chamber The A-Chamber works with a large range of BioSpherix Ltd. gas controllers. These controllers continuously monitor atmospheric condition, ensuring humane conditions as well as experimental integrity for Hypoxia studies.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Imaging System - Slide Scanner	Aperio ScanScope CS Digital Slide Scanner CS Brightfield 5 slide scanner with two workstations with Aperio brightfield imaging analysis software.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Imaging System - Slide Scanner	Aperio Scan Scope FL Fluorescent Digital Slide Scanner 5 slide scanner with Indica Labs fluorescence imaging analysis software.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Flow Cytometer - Magnetic-Activated Cell Sorter (MACS)	Miltenyi MACSQuant Analyzer 7 Flow Cytometer The MACSQuant Analyzer is a powerful benchtop flow cytometer for highly sensitive, multiparameter cell analysis. MACSQuant Analyzers offer fully automated instrument setup via pre-set calibration and compensation programs. Automated startup, shutdown, and cleaning cycles make for hassle-free instrument housekeeping. The MACSQuantify Software provides a powerful and easy-to-use user interface for instrument control, data acquisition, and fully automated analysis.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Evaporator	Buchi RotaVapor R215 Evaporator Rotary evaporator for removing solvents.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Imaging System - Echocardiograph	VisualSonics, Vevo 2100 Imaging System A high-frequency, high-resolution digital imaging platform with linear array technology and Color Doppler Mode. The Vevo 2100 Imaging System enables in vivo visualization, assessment, and measurement of anatomical structures and hemodynamic function in longitudinal imaging studies for small animal and zebrafish phenotyping.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Channel Cycling Metabolic System	OmniTech ElectronicsModel #80 AP4RAT AccuPacer 4 Channel Rat Treadmill and #75 MS8 8 For rodent cardiopulmonary exercise testing
IDeA COBRE for CardioPulmonary Vascular Biology Core	Microscope	Nikon Ni-E upright research microscope Capture both phase, DIC, brightfield and fluorescence images at high magnification with enhanced features such as Z-stack imaging and multi-channel
IDeA COBRE for CardioPulmonary Vascular Biology Core	Spectrophotometer	NanoDrop Measures the concentration of peptides, DNA and RNA, purified protein, nanoparticles, perform protein assays and optical density measurements
IDeA COBRE for CardioPulmonary Vascular Biology Core	Ventilator - Mechanical	SCIREQ FlexiVent Contains a computer-controlled precision piston pump that can intersperse mechanical ventilation with a variety of volume and pressure controlled maneuvers to obtain accurate, reproducible measurement of respiratory mechanics for pulmonary research.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Imager and Microplate Reader	BioTek Cytation 5 microplate reader Imaging plate reader; 5 colors (brightfield, GFP, RFP, DAPI, Cy5) 4x, 10x, 20x objectives.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Imaging system - Laser Doppler	Moor instruments, laser Doppler imaging system Laser Doppler Imaging examines blood flow non-invasively. Used to examine blow flow in capillary beds in response to pulmonary hypertension, exercise, and/or ischemia/reperfusion.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Cell Isolation and Tissue Culture Core	Service The function of the Cell Isolation and Tissue Culture Core is to provide efficient, economical, and reproducible isolation of pulmonary and cardiac endothelial cells, fibroblasts, vascular smooth muscle cells, epithelial cells, macrophages; propagation, and phenotypic characterization and function.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Organ Function Core	Service To provide measurement of heart, lung, and vessel function, in vivo angiogenesis, and transient gene manipulation in vivo. The COBRE Core will provide expertise and state of the art equipment for assessing heart, lung, and vessel function, in vivo angiogenesis, and transient gene manipulation in vivo. The Cell/Organ Core has been measuring heart and lung function using echocardiogram and Flexivent™ methodological approach.
IDeA COBRE for CardioPulmonary Vascular Biology Core	Respiratory Core	Service The mission of the Respiratory Core is to develop centralized systems for cardiopulmonary structural/functional assessments and mitochondrial function analysis, with the goal to enhance the productivity and the research impact of CPVB COBRE investigators and others in the state of Rhode Island. We are committed to providing reproducible, economical, and high-quality services. We offer consultation on experimental design, provide cutting edge technological approaches and high-end instrumentation, generate and analyze data.
IDeA COBRE for Stress, Trauma, and Resilience (STAR)	STAR COBRE for Stress, Trauma, and Resilience	Clinical Research Resources, Stress, Trauma, and Resilience The STAR COBRE aims to foster transdisciplinary collaborations within Brown University, to provide training opportunities for researchers and clinicians who want to address stress and trauma, to enhance partnerships with local and community stakeholders, and to affect policy at the local, national, and international levels.
IDeA COBRE for Stress, Trauma, and Resilience (STAR)	Technology, Assessment, Data, and Analysis Core (TADA)	Clinical Research Resources The TADA Core will offer unique expertise in leveraging technology for observational, laboratory, and intervention studies critical for (1) obtaining ecologically-valid data on stress exposures, behavioral and physiological responses with high temporal resolution, (2) novel approaches to digital phenotyping, and (3) electronically-delivered adaptive interventions.
IDeA COBRE for Stress, Trauma, and Resilience (STAR)	Community Collaborative Core	Clinical Research Resources The Community Collaborative Core will support the overall goals of the STAR COBRE by building critical infrastructure to support clinically significant and highly innovative research with vulnerable children and adults with stress and trauma histories.
IDeA COBRE on Opioids and Overdose	IDeA COBRE on Opioids and Overdose	Clinical Research Resources, Opioids and Overdose The COBRE aims to develop and sustain a vibrant interdisciplinary center of research excellence on opioids and overdose. The COBRE will support the selection, mentorship, and career development of junior investigators performing research in the area of opioids and overdose. The Center will bring together an interdisciplinary group of accomplished senior scientists, promising junior investigators, and distinguished advisors and collaborators to work closely together to establish a center of excellence in an area of clinical research that is of critical public health importance.
IDeA COBRE on Opioids and Overdose	Data and Research Methods CoreData and Research Methods Core	Service The Data and Research Methods (DRM) Core provides study design and methodological expertise, delivers data management resources, offers data visualization services, and addresses analytical needs shared by investigators who lack access to these resources within their own research groups.
IDeA COBRE on Opioids and Overdose	Translational and Transformative CoreTranslational and Transformative Core	Service The Translational and Transformation (T2) Core provides technical assistance in the execution of translation and implementation of science research and supports the dissemination of innovative findings to transform care for opioid addiction and overdose.
IDeA COBRE on Opioids and Overdose	Special Populations CoreSpecial Populations Core	Service The Special Populations Core (SPC) provides infrastructure to recruit and retain vulnerable and underserved individuals, builds capacity in the ethical conduct of research with vulnerable populations, and serves as a centralized resource for training and outreach regarding the conduct of research among individuals most impacted by overdose and opioid-related harms.
Imaging and Molecular Biology and Nanomedicine Core	Microplate Reader Contact: Cherie Charbonneau	Molecular Devices SpectraMax M2e plate reader Features top and bottom read capability for absorbance, fluoresence, luminescence, and time-resolved fluorescence.
Imaging and Molecular Biology and Nanomedicine Core	Oven - Hybridization Oven Contact: Cherie Charbonneau	Fisher Scientific Isotemp hybridization chamber Temperature range of +7C to 85C. Includes a rotisserie.
Imaging and Molecular Biology and Nanomedicine Core	Incubator - Shaker Contact: Cherie Charbonneau	Lab Companion SI-600 Incubated Shaker Bacterial culture shaker with a temperature of ambient to +60C.
Imaging and Molecular Biology and Nanomedicine Core	Luminometer Contact: Cherie Charbonneau	Promega Glomax 20/20 luminometer with printer Ultrasensitive luminescence detection in a single microcentrifuge tube (1.5ml) format.
Imaging and Molecular Biology and Nanomedicine Core	PCR Thermal Cycler Contact: Cherie Charbonneau	Bioer Life ECO thermal cycler This thermal cycler has a 96 well format with a 2C/sec ramp rate.
Imaging and Molecular Biology and Nanomedicine Core	PCR Thermal Cycler Contact: Cherie Charbonneau	Applied Biosystems ProFlex thermal cycler This thermal cycler has a 3x32 well format that allows for 3 separate programs to be run. The ramp rate is 6C/sec.
Imaging and Molecular Biology and Nanomedicine Core	PCR Thermal Cycler Contact: Cherie Charbonneau	Applied Biosystems Veriti thermal cycler This thermal cycler has a 96 well format with 3.9C/sec ramp rate.
Imaging and Molecular Biology and Nanomedicine Core	Imaging System - Gel Imager Contact: Cherie Charbonneau	LI-COR Odyssey Classic Infared Imaging system This near-infared fluorescent detector can be used for quantitative western blots, gel shift assays, coomassie stains, tissue section and small animal imaging.
Imaging and Molecular Biology and Nanomedicine Core	Imaging System - Gel Imager Contact: Cherie Charbonneau	UVP GelCam 310 Bioimaging digital gel documentation system High resolution 2.0 GelCam 310 CCD with manual zoom lens for fluorscent and colorimetric gel imaging. EtBr filter included.
Imaging and Molecular Biology and Nanomedicine Core	PCR Thermal Cycler Contact: Cherie Charbonneau	MJ Opticon 2 real-time PCR system. This 96-well system accepts low-profile tubes or plates. There are two fluorophore channels with emission spectra in the 523-543 nm range and 540-700nm.
Imaging and Molecular Biology and Nanomedicine Core	Incubator Contact: Cherie Charbonneau	(4) NuAire IR water-jacketed CO2 incubators (NU-8500) This incubator provides an optimal in-vitro growth environment for both cell and tissue culture while minimizing dessication through a closed loop HEPA filtration system.
Imaging and Molecular Biology and Nanomedicine Core	Biological Safety Cabinet Contact: Cherie Charbonneau	(4) NuAire Bio Safety Cabinets (Class II, Type A/B3) These biological safety cabinets reduce exposure to airborne biological or particulate chemical agents in low to moderate risk-hazard research and/or drug preparations.
Imaging and Molecular Biology and Nanomedicine Core	Centrifuge Contact: Cherie Charbonneau	Sorvall Legend X1R centrifuge Process samples for diverse laboratory applications with rotors for 1.5ml eppendorf tubes, 15, and 50ml conical tubes. Refrigerated with a max speed of 152000 rpm.
Imaging and Molecular Biology and Nanomedicine Core	Autoclave Contact: Cherie Charbonneau	Amerex HVE-50 top loading autoclave sterilizer This is a 50L, self-contained, portable, top-loading autoclave with auto-exhaust and warming cycles.
Imaging and Molecular Biology and Nanomedicine Core	Microscope Contact: Cherie Charbonneau	Nikon Eclipse TS-100F Inverted Microscope This phase contrast microscope used for tissue culture is also equipped with FITC and TRITC filters to capture fluorescent images in SPOT imaging software.
Imaging and Molecular Biology and Nanomedicine Core	Microscope Contact: Cherie Charbonneau	Nikon Eclipse 90i Upright Research Microscope This microscope is equipped with two cameras (color and monochromatic) and is ideal for brightfield and/or epi-fluorescent images of whole tissues etc with 4x, 10x, 20x and 40x dry objectives. The filter cubes available are DAPI, FITC, and TRITC.
Imaging and Molecular Biology and Nanomedicine Core	Fluorescence Activated Cell Sorter (FACS) Contact: Cherie Charbonneau	Becton Dickinson - Accuri Flow Cytometer This system is equipped with a blue and red laser, two light scatter detectors, and fluorescence detectors with optical filters optimized for FITC, PE, PerCP, and APC. The user does not need to adjust detector voltages and there is a wide dynamic range of digitally collected data (7.2 decades).
Imaging and Molecular Biology and Nanomedicine Core	Bioanalyzer Contact: Cherie Charbonneau	Invitrogen Luminex 200 with xMap technology This is a versatile, efficient standard in multiplexing with the ability to use magnetic or polystyrene beads on up to 100 targets/sample.
Imaging and Molecular Biology and Nanomedicine Core	pH Meter Contact: Cherie Charbonneau	Orion pH meter 920 pH range of -2 to 19.99 and oxygen range of -2 to 19.99ppm. Autocalibration buffers of 4.01, 7, and 10.01.
Imaging and Molecular Biology and Nanomedicine Core	pH meter Contact: Cherie Charbonneau	Hanna Instruments 2209 This pH meter features manual pH calibration and temperature compensation.
Imaging and Molecular Biology and Nanomedicine Core	Microtome Contact: Cherie Charbonneau	Thermo Scientific Shandon Finesse 325 manual microtome With a lightly balanced flywheel it is ideal for routine paraffin sectioning.
Imaging and Molecular Biology and Nanomedicine Core	Sample Preparation - Cutter Contact: Cherie Charbonneau	Buehler-Isomet Cutter The IsoMet Low Speed Cutter is a precision sectioning saw designed for cutting various types of materials with minimal deformation. Its low kerf loss capability and great versatility in holding all types of sample shapes and configurations, gives today's laboratory a precision sectioning tool capable of cutting viturally any material including brittle or ductile metals, composites, cements, laminates, plastics, electronic devices and biomaterials. The Cutter is equipped with a diamond studded carborundum wheel and Buehler Ecomet 4 grinder/polisher with Automet 2 powerhead.
Imaging and Molecular Biology and Nanomedicine Core	Imaging System Contact: Cherie Charbonneau	PerkinElmer FMT 4000 Fluorescence Tomography System. The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. The system comes with four excitation laser channels (635, 680, 750, and 790 nm) and is useful for a range of applications including oncology, inflammation, and cardiovascular disease. It is ideal for researchers who are well-versed in 3D fluorescence tomography and require the widest range of in vivo applications and imaging agents.
Imaging and Molecular Biology and Nanomedicine Core	Imaging System Contact: Cherie Charbonneau	Faxitorn Pre-clinical imaging system Ultra-high resolution x-ray imaging is an important tool in investigating a variety of disease states. From metastatic cancer to arthritis and osteoporosis, small animal models are commonly used. Both in vivo and ex vivo planar imaging is used to screen, track, and evaluate structural changes in these studies. Cabinet x-ray systems allow researchers to take images directly in the vivarium to protect the integrity of the colony. These planar imaging systems are less expensive, subject animals to lower doses, and provide faster results than microCT systems.
Imaging and Molecular Biology and Nanomedicine Core	Incubator Contact: Cherie Charbonneau	GQF 1502 Sportsman egg incubator This is a complete incubator and hatching system with 3 automatically turned racks. It has an accurate digital thermostat with LCD of humidity and temperature.
Imaging and Molecular Biology and Nanomedicine Core	Homogenizer Contact: Cherie Charbonneau	Fisher Scientific, Powergen 125 Tissue Homogenizer Process volumes from 0.03 to 100mL. Variable speed control to 30,000rpm for efficient cell disruption. Disposable plastic generators eliminate sample cross-contamination. Flat-bottom stainless-steel generators process liquid or soft tissues.
Imaging and Molecular Biology and Nanomedicine Core	Microscope Contact: Cherie Charbonneau	Olympus SZ61 Zoom Stereomicroscope Greenough design with two optical paths inclined at an inward angle. Magnification range 0.67X to 4.5X; zoom ratio 6.7:1; FN 22. Working distance of 100mm; observation tube angle 45 degrees; right and left eyepiece tubes interlocked; interpupillary distance adjustment 50-76mm; forward positioned zoom adjustment knobs with zoom magnification graduations. With 0.5x cmount for documentation.
Imaging and Molecular Biology and Nanomedicine Core	Chemical Hood Contact: Cherie Charbonneau	Thermo Scientific Hamilton SafeAire II Chemical hood and ultra-high vacuum system for organic synthesis
Imaging and Molecular Biology and Nanomedicine Core	Evaporator Contact: Cherie Charbonneau	Buchi R-124 Rotavapor Rotary evaporator comes complete with a 45 degree water condenser and a 1L condensing and evaporating flask.
Imaging and Molecular Biology and Nanomedicine Core	Sample Preparation - Circulator Contact: Cherie Charbonneau	VWR Recirculating Chiller, Model 1160A Stable cooling for many common heat removal applications such as rotary evaporators and vacuum systems (-10 to 40C).
Imaging and Molecular Biology and Nanomedicine Core	High Performance Liquid Chromatography (HPLC) Contact: Cherie Charbonneau	Agilent Technologies, 1260 Infinity HPLC system A maximum pressure of 600 bar to utilize smaller particle size columns for higher resolution and faster separations.
Imaging and Molecular Biology and Nanomedicine Core	Disrupter Contact: Cherie Charbonneau	Qsonica 700W sonicator with 5.5" cup horn This sonicator has full amplitude control from 1-100%.
Imaging and Molecular Biology and Nanomedicine Core	Imaging System Contact: Cherie Charbonneau	Xtreme back illuminated 4MP with x-ray for small animal imaging High sensitivity luminescence, fluorescence, radioisotopic, and radiographic imaging for up to 5 mice at a time. Isofluarne and temperature controlled chamber for the mice.
Imaging and Molecular Biology and Nanomedicine Core	PCR Thermal Cycler - Digital Contact: Cherie Charbonneau	RainDrop Digital PCR by RainDance The RainDrop is composed of a Source instrument that can generate 10million droplets/sample and the Sense instrument, which can detect whether the PCR reactions are positive or negative for your fluorophore. Multiplexing is possible for the 8 samples that are run at a time on the microfluidics chip.
Imaging and Molecular Biology and Nanomedicine Core	PCR Thermal Cycler Contact: Cherie Charbonneau	Bio-Rad CFX96 Real-Time PCR system This real-time PCR instrument allows for up to 5-target multiplexing in sample volumes as small as 10ul. It also has a thermal gradient feature in a 96-well format.
Imaging and Molecular Biology and Nanomedicine Core	Spectrophotometer Contact: Cherie Charbonneau	Thermo Scientific NanoDrop 2000c This is a full spectrum, UV-Vis spectrophotometer used to quantify and assess the purity of DNA, RNA, protein, and more at sample volumes as low as 0.5ul.
Imaging and Molecular Biology and Nanomedicine Core	Bioreactor Contact: Cherie Charbonneau	Flexcell FX5000 Tension System This is a computer-regulated bioreactor that uses vacuum pressure to apply either cyclic or static strain to cells cultured on flexible-bottomed culture plates.
Imaging and Molecular Biology and Nanomedicine Core	Sample Preparation - Freeze Dry System Contact: Cherie Charbonneau	Labconco FreeZone Plus 2.5L Cascade Benchtop Lyophilizer This system is for light sample loads with low eutectic points. It can remove up to 1.8L of water in 24hrs and holds 2.5L of ice before defrosting is required.
In Vivo Optical Imaging Core (Legorreta Cancer Center at Brown University)	Training and Technical Assistance	Service Advise investigators with experimental design for in vivo imaging applications, provide access to instrumentation and training. Assist investigators with in vivo mouse, organ or cellular imaging, probe selection, antibody labeling, image analysis and presentation. Provide support for grant submissions.
Infectious Diseases Clinical Research Program - The Miriam Hospital	Research - Infectious Diseases Clinical Research Resources Contact: Karen Tashima	Clinical Trials Support, HIV and HCV The Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel. The unit conducts trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C. Other studies offered through our clinical trials unit include pharmaceutical studies to treat hepatitis C, prevent C. difficile infection, and test new methods of diagnosing HIV infection.
Institute for Immunology and Informatics (iCubed)	Research - Immunology and Informatics Resources	Clinical Research Resources, Immunology and Informatics iCubed’s research focuses on creating new and safer vaccines. We also explore new methods of predicting and treating adverse immune responses. iCubed supports a wide variety of training efforts that provide opportunities to advance women and students in science which include unique technology toolkits and hands-on laboratory experiences.
Joint Engineering Physics Instrument Shop (JEPIS)	Fabrication - Machine Shop	Service that provides machine shop capabilities The Joint Engineering Physics Instrument Shop (JEPIS) is a specialized service center providing assistance in the development of experimental instruments, research projects and instructional classes. The JEPIS services are offered to faculty, students and staff on the Brown University campus, and is also available to outside academic/hospital users. JEPIS offers all of the basic machine shop capabilities, including Wire EDM and Rapid Prototype printing. JEPIS also offers CNC design consultation, hands on training and instruction through non-credit basic machine shop course and an advanced course geared toward Graduate Students. The Student Shop provides students with a strong base for their experimental studies. The JEPIS staff is available to give general advice and assistance to the Brown Students and Staff in the finding of sources for the materials and devices they require for their projects or instructional classes. Access to the facility is on a user fee basis of an hourly fee for labor plus materials.
Leduc Bioimaging Facility	Software - Analysis	Software: Amira 2019 Software for image analysis and 3D visualization
Leduc Bioimaging Facility	Sample Preparation - Critical Point Dryer	Ladd Research Industries Removes liquid from biological specimens for SEM
Leduc Bioimaging Facility	Sample Preparation - Glow Discharge Unit	Emitech K100X Adds a charge to make TEM samples hydrophilic
Leduc Bioimaging Facility	Microscope - Multiphoton	Olympus FV-1000-MPE Multiphoton Laser Scanning Microscope Deep optical sectioning of fluorescently labeled samples with SIM photoactivation
Leduc Bioimaging Facility	Microscope - Fluorescence	Zeiss Axiovert 200M Fluorescence Imaging of samples labeled with fluorescent indicators
Leduc Bioimaging Facility	Microscope - Fluorescence	Zeiss Axiovert 200M Fluorescence Imaging of samples labeled with fluorescent indicators
Leduc Bioimaging Facility	Microscope - Confocal	Olympus FV3000 Confocal Microscope Optical sectioning of samples labeled with fluorescent indicators. Equipped with a resonant scanner for fast optical sectioning
Leduc Bioimaging Facility	Microscope - Confocal	Zeiss LSM 710 Confocal Optical sectioning of samples labeled with fluorescent indicators
Leduc Bioimaging Facility	Microscope - Fluorescence	Zeiss Lumar Stereo Fluorescence Imaging of samples labeled with fluorescent indicators
Leduc Bioimaging Facility	Microscope - Electron	Thermo Apreo VS Scanning Electron Microscope (SEM) for serial block-face imaging Equipped for standard scanning electron microscopy as well as serial-block face imaging. The automated system is capable of imaging large z-stacks at isotropic 10x10x10 nm resolution. The series of images can be processed for 3D reconstruction of cells and tissues, with sufficient resolution to identify small vesicles, organelles and neural connections.
Leduc Bioimaging Facility	Microscope - Electron	Philips 410 Transmission Electron Microscope (TEM) Transmission electron microscopy with Advanced Microscopy Techniques (AMT) Camera Accessory
Leduc Bioimaging Facility	Microtome	Reichert Ultramicrotome Ultrathin sectioning for light microscopy and transmission electron microscopy
Leduc Bioimaging Facility	Microtome Diamond Knife Set	Diatome DKS Used on Reichert microtome to cut ultrathin sections for TEM
Leduc Bioimaging Facility	Sample Preparation - Sputter Coater System	Emitech K550 Covers an EM specimen with a thin layer of conducting material
Leduc Bioimaging Facility	Training and Technical Assistance - Bioimaging	Service Service to provide Bioimaging technical assistance and training
Leduc Bioimaging Facility	Microscope - Fluorescence	Nikon Ti2-E Fluorescence Microscope Motorized fluorescence microscope with Perfect Focus System and software for high-content screening and 2D/3D deconvolution.
Leduc Bioimaging Facility	Microscope - Confocal	Zeiss LSM 800 Confocal Optical sectioning of samples labeled with fluorescent indicators
Leduc Bioimaging Facility	Microtome	Leica EM UC7 Ultramicrotome Biological TEM and SBF prep
Leduc Bioimaging Facility	High-Content Screening System Contact: Samantha Madnick Opera Phenix High-Content Screening System Website	PerkinElmer Opera Phenix High Content Screening System Microscope designed for high-throughput 3D imaging of fluorescent samples in microplates.
Leduc Bioimaging Facility	Microscope - Fluorescence	Nikon Ti2-E Fluorescence Microscope for high-content imaging The Nikon Ti2-E fluorecence microscope is a high-content imaging system, based on an inverted microscope and equipped for imaging standard slides, culture dishes, and microplates (e.g. 96-well plates). The microscope includes 'Perfect Focus' for autofocus applications, a Photometrics Prime 95B sCMOS camera for imaging fluorescence, a 16 megapixel Nikon DS-Ri2 color camera for imaging histology slides, a motorized stage and NIS-Elements High Content (HC) software for multiwell plate acquisition.
Leduc Bioimaging Facility	Microscope - Confocal	Zeiss LSM 880 Confocal Optical sectioning of samples labeled with fluorescent indicators
Leduc Bioimaging Facility	Microscope - Slide Scanner	Olympus VS200 Automated slide scanner for imaging fluorescence and brightfield (e.g. H&E slides).
Lentivirus Construct Core (Legorreta Cancer Center at Brown University)	Lentivirus-mediated Stable Gene Over-expression in Cells	Service
Lentivirus Construct Core (Legorreta Cancer Center at Brown University)	Lentivirus-mediated CRISPR/Cas9 Gene Knock-out in Cells	Service
Lentivirus Construct Core (Legorreta Cancer Center at Brown University)	Site-directed Mutagenesis	Service
Lentivirus Construct Core (Legorreta Cancer Center at Brown University)	Virus Packaging	Service
Lentivirus Construct Core (Legorreta Cancer Center at Brown University)	Design and production - COVID-19 Pseudovirus	Service
Lentivirus Construct Core (Legorreta Cancer Center at Brown University)	Cell entry assays - COVID-19 Pseudovirus	Service
Lentivirus Construct Core (Legorreta Cancer Center at Brown University)	SARS-CoV-2 spike and human ACE2 constructs	Service
Lifespan Biostatistics, Epidemiology, and Research Design (BERD)	Technical Assistance - Biostatistics, Epidemiology, and Research Design Consulting Contact: Jason Machan, PhD	Service The Biostatistics, Epidemiology, and Research Design (BERD) Core at Rhode Island Hospital offers centralized biostatistics consultation services to clinical, basic, and translational researchers. We provide a broad array of resources during all phases of research. During planning, the core can provide high quality project/trial design, including final sculpting of specific aims and hypotheses, measure selection, power analysis, data analysis planning, and grant/proposal preparation. At the beginning of the project, the core can assist in construction of REDCap data collection tools, databases, and data management, including national archiving. We provide help navigating approvals for special technology needs, such as purchasing non-standard equipment and logistics. Throughout the trial, the core can provide decision support, assessing the impact of potential design additions or changes on final statistical inference. It can serve on or help find individuals to serve on data and safety monitoring boards (DSMB). At the conclusion of the trial, the core can assist with implementation of the data analysis plan, either by providing access to contemporary statistical analysis software and coaching, or by conducting analyses for or with investigators. During reporting/publication preparation, the core can assist in write-up, data visualization, and integration of interpretations in the broader context of the project, and help address comments from peer reviewers.
Magnetic Resonance Imaging (MRI) Facility	Imaging System - Magnetic Resonance Imaging (MRI) Scanner	Siemens 3 Tesla Prisma fit Brain structure and function in normal and clinical populations as well as studies of other body systems, non-invasive animal imaging and materials science.
MakerspaceURI	Imaging System - 3D Scanner	EinScan Pro 2X
MakerspaceURI	Tools - Router - computer numerical control (CNC)	Inventables X-Carve
MakerspaceURI	Cutter - Laser	GCC Laserpro Spirit LS
MakerspaceURI	Imaging System - Audio\|Visual - VR Headsets	HTC Vive Pro (3); Oculus Quest 2 (2)
MakerspaceURI	Sewing Machines/ Embroidery	Brother XM2701 Sewing Machine (2), Brother PE-770 Embroidery System
MakerspaceURI	Imaging System - 3D Printer	Makerbot Replicator+ (2); Dremel 3D20 (9); TAZ Workhorse; Formlabs (2)
MakerspaceURI	Computer - Tablets	IPad 7th Gen (4), Microsoft Surface
MakerspaceURI	Imaging System - Camera	Sony Alpha a6400 Mirrorless Digital Camera (with a tripod and accessories)
MakerspaceURI	Computers	DELL high-performance PCs (4), Alienware PC (3)
MakerspaceURI	Vacuum Former	Vaquform DT2
MakerspaceURI	Cutter - Vinyl	GCC Expert Pro Vinyl Cutter, Cameo Silhouette (2)
Mansfield Bio-Incubator (Independent Nonprofit)	Workstation - Laboratory and office spaceMansfield Bio-Incubator 2020 Rates	Mansfield Bio-Incubator Mansfield Bio-Incubator is a non-profit organization whose mission is to facilitate and assist the creation, growth, and success of the next generation of biotech companies. Our incubator assists these companies and nurtures entrepreneurial and economic development in the community by maintaining affordable lab and office space, services, training, mentoring, and a network of professional advisors. Shared and private office and lab space are available, with additional space coming online in 2021. More information on the membership rates can be found here. https://www.bioinc.org/membership-rates-2
Mansfield Bio-Incubator (Independent Nonprofit)	Chemical Hood	Labconco Protector Premier Fume Hood Suitable for providing personal protection needed for general chemistry applications involving fumes and vapors.
Mansfield Bio-Incubator (Independent Nonprofit)	Biological Safety Cabinet	Labconco Purifier Logic Series Biological Safety Cabinet Provide personnel, product and environmental protection from hazardous particulates and agents that require biosafety level 1 or 2 containment.
Mansfield Bio-Incubator (Independent Nonprofit)	Incubators (2)	VWR Symphony CO2 incubator CO2 incubators designed to maintain adequate interior moisture to prevent the drying out of cultures.
Mansfield Bio-Incubator (Independent Nonprofit)	PCR Thermal Cycler	Illumina Eco real-time PCR system The Eco Real-Time PCR System offers life science researchers a full-featured real-time PCR system at an attractive price. Its features include:  Four-color multiplexing  High Resolution Melt (HRM)  Fast PCR cycling: 40-cycle PCR in 40 minutes  User-friendly, MIQE-compliant software.
Mansfield Bio-Incubator (Independent Nonprofit)	Mass Spectrometer	Agilent LC/MSD VL mass spectrometer The Agilent 1100 Series LC/MSD offers you the sensitivity, selectivity, and depth of molecular information inherent in mass spectrometry—in a package that is rugged, reliable, and surprisingly easy to learn, operate, and maintain
Mansfield Bio-Incubator (Independent Nonprofit)	Microplate Reader - Fluorescence	Fluoroskan Ascent Measures sample fluorescence Excitation wavelengths 320-700 nm, emission 360-700 nm
Mansfield Bio-Incubator (Independent Nonprofit)	High Performance Liquid Chromatography (HPLC)	Agilent 1100 HPLC system
Mansfield Bio-Incubator (Independent Nonprofit)	BioBank - Biospecimen Banking - Freezer	NuAire -85C Ultralow Temp Freezer Sample storage
Mansfield Bio-Incubator (Independent Nonprofit)	BioBank - Biospecimen Banking - Freezer	Kenmore -20C Freezer Sample storage
Mansfield Bio-Incubator (Independent Nonprofit)	BioBank - Biospecimen Banking - Refrigerator	4C Glass Door Sample storage
Mansfield Bio-Incubator (Independent Nonprofit)	Luminometer	Digene DML 2000 luminometer The DML 2000 instrument is a luminometer that automates amplified chemiluminescent signal detection and results reporting for Hybrid Capture 2 (HC2) assays,
Marine Science Research Facility	Sensor - Oxygen Sensor	PreSens Water phase analysis
Marine Science Research Facility	Analyzer - Dissolved Gas	Bay Instruments Membrane Inlet Mass Spectrometer- Dissolved Gas Analyzer Mass Spectrometer: Quantifies dissolved gases
Marine Science Research Facility	Analyzer - Multiparameter Water Analyzer	YSI Professional Plus Hand Held Multiparameter Water Meter Measures temperature, salinity, dissolved oxygen (DO), and pH
Marine Science Research Facility	Analyzer - Nutrient	Lachat QuickChem 8500 Flow Injection Nutrient Auto Analyzer Measures dissolved nutrients in water, Ammonia, Phosphate, Nitrite, Nitrate, and Silicate
Marine Science Research Facility	Aquatic Culture - Algae and Live Feed Room Contact: Ed Baker	Various manufacturers K-walls, small rearing tanks for live feed, flowing seawater and freshwater
Marine Science Research Facility	Aquatic Culture - Phytoplankton Culture Wheels Contact: Ed Baker	Various manufacturers Motorized and water driven, clear plexiglass, ambient and experimental temperature control, can accommodate culture bottles of differing sizes (1-3L)
Marine Science Research Facility	Aquatic System - Dechlorination System - Freshwater Contact: Ed Baker	Various manufacturers 2 Freshwater dechlorination tanks
Marine Science Research Facility	Disrupter	Biospec Mini Bead Beater Shakes tubes with beads to disrupt cells, DNA , RNA
Marine Science Research Facility	Disrupter	Branson Digital Ultasonic Liquid Sonifier Disrupts cells
Marine Science Research Facility	Workstation - Environmental Chamber Contact: Ed Baker	EnvironAir Environmental Chamber 100 sq ft Temperature control, Two range 4-24 C, Two range -4-24 C (to simulate polar conditions), On generator back up and emergency monitoring systems. (4 Units)
Marine Science Research Facility	Aquatic System - Flowing Seawater System Contact: Ed Baker	Various manufacturers Raw-Ambient temperature and Filtered- Chilled, Heated, Ambient. UV treated, air supply, emergency monitoring systems
Marine Science Research Facility	Fluorescence Activated Cell Sorter (FACS)	Becton Dickinson (BD) Biosciences Influx Flow Cytometer and Cell Sorter Measures light scatter and fluorescence of cells. Sorts cells based on measured properties.
Marine Science Research Facility	Fluorometer	Satlantic Fluorescence Induction Relaxation Fluorometer (FIRE) Measures variable fluorescence in phytoplankton
Marine Science Research Facility	Fluorometer	Turner Designs 10-AU (Chlorophyll) Field Fluorometer Measures extracted or in vivo chlorophyll fluorescence of samples, Field-portable, can be set up for continuous-flow monitoring or discrete sample analyses
Marine Science Research Facility	Fluorometer	Life Technologies Qubit Fluorometer Quantifies DNA, RNA, and protein
Marine Science Research Facility	Biospecimen Banking - Freezer - Walk-in Contact: Ed Baker	-20 C Walk-In Freezer 185 sq ft Long term storage, On generator back up and emergency monitoring systems
Marine Science Research Facility	Homogenizer	Polytron Homogenizer PT-10-35-GT Breaks down plant and animal tissue for analysis, and performs homogenization, dispersion, mixing, and prepares emulsions
Marine Science Research Facility	Cell Counter	Sizing and counting of particles suspended in liquid samples Beckman Coulter Multisizer 4
Marine Science Research Facility	Imaging System - Camera	Olympus EP50 Microscope Camera w/ HDMI Monitor Captures Microscope video and still images (C-mount)
Marine Science Research Facility	Analyzer - Fluid Particle Counter and Imager	Fluid Imaging Technologies FlowCam Imaging Particle Analysis: counts and records images of particles in liquid samples
Marine Science Research Facility	Incubator	Percival Incubator/Growth Chamber Temperature and light controlled incubator for environmental applications
Marine Science Research Facility	Microplate Reader	Molecular Devices Spectramax M5 Measures Fluorescence Intensity, Absorbance, Time Resolved Fluorescence, Fluorescence Polarization and Luminescence in cuvettes and multiple sized microplates.
Marine Science Research Facility	Microscope	Nikon inverted Microscope Microscopy. Works with Olympus EP50 Camera
Marine Science Research Facility	Microscope	Olympus SZX16 Stereo Microscope Microscopy. Works with Olympus EP50 Camera
Marine Science Research Facility	PCR Thermal Cycler	Eppendorf Master Cycler Pro Replicates DNA
Marine Science Research Facility	PCR Thermal Cycler	Stratagene QPCR Mx3000P Analysis of gene expression, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Quantitative PCR Filters- FAM/Syber Green, Rox, Hex, CY3, CY5
Marine Science Research Facility	Photoperiod controller Contact: Ed Baker	Various manufacturers Wattstopper controller(Blount), Various individual timers
Marine Science Research Facility	Pier Access Contact: Ed Baker	Access to Graduate School of Oceanography pier Access to pier for deployment, collection, testing. Water depths 18-15 feet to intertidal zone
Marine Science Research Facility	Radiometer	Biospherical Instruments Quantum Scalar Laboratory (QSL) Radiometer - PAR Light Meter Measures Photosynthetically Active Radiation (PAR)
Marine Science Research Facility	Incubator - Shaker	Thermo Max-Q Orbital Shaker Table Orbital shaker with 18x24 in platform and variety of clamps
Marine Science Research Facility	Incubator - Shaker	Thermo Max Q Incubated Shaker Heated incubated shaker
Marine Science Research Facility	Spectrometer	Ocean Optics Jaz Spectrometer Optical sensing instrumentation that measures light wavelengths. Its unique features and expandable platform makes it uniquely suited for field applications, remote sensing, process flow and quality assurance.
Marine Science Research Facility	Spectrophotometer	Thermo Scientific NanoDrop 1000 Microvolume UV-Vis spectrophotometer that quantifies DNA, RNA, and protein from small 1-2 microliter sample size
Marine Science Research Facility	Aquatic System - Laminar Flow Tank Contact: Ed Baker	Laminar Flow Tank 1000 gal, Seawater or Freshwater, Multiple speeds with precision control. Experimental chamber visable from 5 sides
Marine Science Research Facility	Aquatic System - Mesocosm Tank Contact: Ed Baker	Various manufacturers 10, 5 ft deep outdoor mesocosms, with available raw ambient seawater flow
Marine Science Research Facility	Vacuum Manifold Contact: Rodrigue Spinette	Vacuum Filter Manifold Allows for filtration of 5 ports simultaneously, 25 and 47 mm filter cups available
Marine Science Research Facility	Worksation - Marine General Wet Lab Contact: Ed Baker	Various manufacturers 3 Buildings, 7,000 sq ft indoor, and nearly unlimited outdoor space, Multiple insulated tank sizes, various sized aquaria, possible to perform simultaneous replicates
Marine Science Research Facility	Workstation - Marine Pathology and Transgenics Laboratory and Systems Contact: Ed Baker	Various manufacturers Ozone treated effluent and separate effluent drain
Marine Science Research Facility	Microscope	Nikon Eclipse Ni epifluorescence microscope Epifluorescence and phase microscopy with digital camera system
Marine Science Research Facility	Gas Chromatograph - Mass Spectrometer (GC - MS) Contact: David Adelman	Agilent Technologies 7890B/5977A GC/MSD Identifies and enumerates chemical constituents of samples
Marine Science Research Facility	Imaging System - Gel Imager	Fluorescence gel imaging system Carestream Molecular Imaging Gel Logic 212 Pro
Marine Science Research Facility	Fluorometer	Turner Designs Trilogy Measures extracted or in vivo chlorophyll fluorescence of samples, Field-portable
Mass Spectrometer Analytical Facility	Mass Spectrometer Contact: Alberto Saal	Thermo Scientific Multi-collector inductively coupled plasma mass spectrometer, ICP-MS, Neptune Plus This is a multi-collector ICP-MS equipped with nine Faraday cups and eight ion counters, which allows us to monitor multiple masses simultaneously providing precise isotope ratio measurement.
Mass Spectrometer Analytical Facility	Mass Spectrometer Contact: Alberto Saal	Thermo Scientific Quadrupole inductively coupled plasma mass spectrometer, ICP-MS, X-series-2 This is a single collector ICP-MS that allows us to measure precise elemental composition at sub-ppb level concentration.
Mass Spectrometer Analytical Facility	Analyzer - Laser Ablation Contact: Alberto Saal	Photon-machines Analyte G2, 193 nm excimer laser ablation This 193 nm wave-length excimer laser allows us to perform in-situ analysis on a solid sample with a beam diameter as small as 3µm. To determine the elemental abundances the laser is coupled with the single collector inductively coupled plasma mass spectrometer ICPMS and to determine the isotope ratios the laser is coupled with multi collector ICPMS.
Mass Spectrometer Analytical Facility	Workstation - Clean lab, metal free Contact: Alberto Saal	Pico Trace Clean Lab This Clean Lab is equipped with Millipore water filtration system that provides greater than 18MΩ Milli-Q water. The working stations in this Clean Lab meet ISO class 4 standard (equivalent to FS class 10) allowing us to perform ultra-low blank chemical analysis.
Mass Spectrometry Facility (Brown Chemistry)	Gas Chromatograph - Mass Spectrometer (GC - MS)	Hewlett-Packard (Agilent) 6890 GC/5973 MSD This system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 450 Da).
Mass Spectrometry Facility (Brown Chemistry)	Liquid Chromatography - Mass Spectrometer (LC - MS)	Agilent 6530 Mass QTOF This system consist of Agilent 1260 infinite HPLC and Agilent 1260 infinite nanoglow LC/chipcube nanoelectrospray MS interface, and 6530 Accurate Mass Q-TOF mass spectrometer. This instrument can detect and identify compounds in amounts smaller than two trillionths of a gram (2 picograms), making the Agilent 6530 a powerful tool for food safety, toxicology and other measurements where minute amounts of compounds must be identified.
Mass Spectrometry Facility (Brown Chemistry)	Mass Spectrometer	Thermo LXQ linear ion trap with Surveyor HPLC system The LXQ has capabilities similar to the conventional 3D ion trap such as LCQ Deca. It is based on linear ion trap technology that has faster cycle time. It is capable of data-dependent LC/MSn analysis.
Mass Spectrometry Facility (Brown Chemistry)	High Performance Liquid Chromatography (HPLC) - Analytical and preparative HPLC	Agilent 1260 Infinity LC The 1260 HPLC is used primarily for analytical and semi-prep scale HPLC separation and purification of components in chemical mixtures. This system consisted a quaternary pump, autosampler, thermostatted column compartment, diode array detector (190 – 950 nm), and fraction collector.
Mass Spectrometry Facility (Brown Chemistry)	Mass Spectrometer	Bruker Autoflex Speed Linear (L) Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometer (MALDI-TOF MS). The Bruker autoflex Speed is a linear time-of-flight (TOF) mass spectrometer equipped with a matrix-assisted laser desorption ionization (MALDI) ion source. This instrument is routinely used for analysis of organic molecules, natural products, and macromolecules, including recombinant proteins, oligonucleotides, polysaccharides and synthetic polymers.
Mass Spectrometry Facility (Brown Chemistry)	Gas Chromatograph - Mass Spectrometer (GC - MS)	Agilent 5977A GC/MSD System This system is suitable for separation of complex mixtures by gas chromatography (GC) and identification by mass spectrometry. It is limited to low molecular weight and volatile molecules (mass range 1050 Da).
Molecular Biology and Imaging Core	Fluorescence Activated Cell Sorter (FACS)	Thermo Scientific Attune NXT Analytical flow cytometer: 4 lasers, 14 colors, with 96 well plate handler capability
Molecular Biology and Imaging Core	Microscope - Spinning disk Contact: Sunil Shaw	Andor CSU-W1 spinning disk confocal system The Spinning disk confocal microscope is a Nikon Ti-E (inverted) with Perfect Focus and motorized stage, with an Andor Zyla 4.2 plus SCMOS camera, an Andor CSU-W1 spinning disk with 405, 488 and 561 nm laser lines, as well as a SpectraX LED widefield light source and controlled by NIS-Elements software. This system is suitable for fast confocal imaging and live cell imaging, with low phototoxicity and long term focus stability. A stage incubator with CO2 and temperature control is available for maintenance of physiological conditions during live cell imaging.
Molecular Biology and Imaging Core	Fluorescence Activated Cell Sorter (FACS)	Becton Dickinson (BD) Biosciences FACSCanto Analytical Flow Cytometer: 2 lasers, 6 colors
Molecular Biology and Imaging Core	Imaging System - Gel Imager	Bio-Rad Chemidoc XRS The ChemiDoc XRS+ system is based on CCD high-resolution, high-sensitivity detection technology and modular options to accommodate a wide range of samples and support multiple detection methods including fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence. The system is controlled by Image Lab software to optimize imager performance for fast, integrated, and automated image capture and analysis of various samples.
Molecular Biology and Imaging Core	Imaging System - Gel Imager	Bio-Rad Molecular Imager FX system Imager with 50 micron resolution and a 5 order of magnitude linear dynamic range for fluorescence and radioisotopic imaging. You can also image and accurately quantitate chemiluminescent samples.
Molecular Biology and Imaging Core	Cell Sorter - Magnetic-Activated Cell Sorter (MACS)	Miltenyi AutoMACS Magnetic cell sorter Automated cell sorter, for separating cell suspensions labeled with magnetic beads
Molecular Biology and Imaging Core	Microplate Reader	Molecular Devices Spectramax Gemini EM Fluorescence Microplate Reader Enables top and bottom reading of microplates over a greater range of fluorescence intensities all without the use of filters.
Molecular Biology and Imaging Core	Microplate Reader	Perkin Elmer TopCount NXT Microplate Scintillation and Luminescence Counter TopCount NXT analyzes two, six, or twelve samples at a time, and counts samples in 24-, 96-, and 384-well microplates, as well as microcentrifuge tubes. It can count gammas, betas, or luminescent samples.
Molecular Biology and Imaging Core	Microscope	Leica MZ FLIII Stereo Fluorescent dissection microscope Dissection microscope with Leica color camera DC300F.
Molecular Biology and Imaging Core	Microscope	Nikon 80i Upright Fluorescence Microscope Upright microscope with color CCD camera Spot Insight 2
Molecular Biology and Imaging Core	Microscope	Nikon TE2000E Inverted fluorescence, A live cell imaging microscope, with cooled CCD camera Roper CoolSnap HQ
Molecular Biology and Imaging Core	Microscope	Zeiss AxioImager M2 Upright Microscope, Upright microscope with color CCD camera AxioCam MRC.
Molecular Biology and Imaging Core	Centrifuge - Ultra	Beckman Coulter Optima XPN-80 Ultracentrifuge SW-32.1Ti. SW-41Ti. TY-70.1Ti, TY70Ti rotors
Molecular Biology and Imaging Core	PCR Thermal Cycler	Applied Biosystems ABI 7500 96-well quantitative PCR
Molecular Biology and Imaging Core	Spectrophotometer	Bio-Rad SmartSpec 90-260 V, UV/visible benchtop spectrophotometer for nucleic acid and protein quantitation, wavelength range 200–800 nm, built-in thermal printer
Molecular Biology and Imaging Core	Spectrophotometer	Thermo Scientific NanoDrop 2000 A full spectral microvolume UV-Vis analysis spectrophotometer for measuring DNA, RNA, and protein.
Molecular Biology and Imaging Core	Suspension Array System	Bio-Rad BioPlex 200 Detection and quantification of multiple analytes (proteins and peptides, or nucleic acids) in a single sample volume.
Molecular Biology and Imaging Core	Cryostat	Frozen tissue sections Thermo Shandon Cryotome E
Molecular Biology and Imaging Core	Microtome	Paraffin embedded tissue sections Thermo Shandon Finesse ME
Molecular Biology and Imaging Core	Histology/Tissue Processing - Paraffin Embedding Workstation	Tissue processing Thermo Shandon Histocenter 2
Molecular Biology and Imaging Core	Centrifuge - Cyto	Thin layer preparation from cell suspensions Thermo Scientific Cytospin 4 Cytocentrifuge
Molecular Biology and Imaging Core	Analyzer - Nanoparticle counter Contact: Sunil Shaw	Malvern Nanosight NS300 Analysis of size distribution and concentration of nanoparticles from 10nm to 2000nm in diameter. A 532nm green laser also allows the detection of red fluorescent particles. A syringe pump allows sample analysis under constant flow, increasing reliability and reproducibility of data.
Molecular Biology and Imaging Core	Imaging System - Gel Imager	Bio-Rad Chemidoc MP The ChemiDoc MP system is based on CCD high-resolution, high-sensitivity detection technology and modular options to accommodate a wide range of samples and support multiple detection methods including fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence. The system is controlled by Image Lab software to optimize imager performance for fast, integrated, and automated image capture and analysis of various samples.
Molecular Biology and Imaging Core	Cell Counter	Nexcelom Cellometer The Auto T4 is a PC-based instrument for one-step 4x bright field image capture and analysis. This state-of-the-art cell counter performs count, size, and Trypan Blue viability analyses that are 10x faster and more accurate than manual counting. This instrument is ideal for cell lines and purified primary cells, including MCF-7 breast cancer cells, PC3 prostate cancer cells, and 1600 other cell types, due to its advanced software that assesses clumpy cells and omits debris
Molecular Biology and Imaging Core	Single Cell Analysis for RNAseq	1Cell Bio InDrop The InDrop enables single cell encapsulation, barcoading of cDNA, preparation of a sequencing librrary, and informatics.
Molecular Pathology Core - Brown	Histology/Tissue Processing - Tissue Sample Processing and Embedding	Service Paraffin Processing and Embedding- automated and manual, Plastic Processing and Embedding, TEM and SEM Processing and Embedding, Frozen Tissue-Embedding in OCT Block, Sample Preparation for Serial Blockface Imaging
Molecular Pathology Core - Brown	Histology/Tissue Processing - Sectioning	Service Paraffin sectioning, plastic sectioning, Frozen/Cryostat prep and sectioning, TEM ultrathin sectioning, Vibratome, Serial and Step sectioning
Molecular Pathology Core - Brown	Paraffin Embedding Workstation	Leica EG1150C Paraffin Embedding Center Paraffin embedding
Molecular Pathology Core - Brown	Microtome	Leica RM2265 Automated Microtome Paraffin and plastic sectioning
Molecular Pathology Core - Brown	Cryostat	Leica CM3050S Cryostat Sectioning of fixed and unfixed frozen samples
Molecular Pathology Core - Brown	Vibratome	Leica VT 1000S Vibratome Sectioning of fixed samples
Molecular Pathology Core - Brown	Biospecimen Banking - Freezer	Revco -80 degree C Freezer Temporary Sample storage
Molecular Pathology Core - Brown	Microscope	Nikon Eclipse 50i light microscope Collaborative analyses of histological slides and digital imaging capability
Molecular Pathology Core - Brown	Histology/Tissue Processing - Staining	Service Hematoxylin and Eosin (H&E), Periodic Acid Schiff (PAS), Masson's Trichrome, Special Stains
Molecular Pathology Core - Brown	Histology/Tissue Processing - Immunolabelling	Service Immunohistochemistry, Immunocytochemistry, Immunofluoresence, Immunogold, TUNEL Assay
Mouse Transgenic and Gene Targeting Facility	Biological Safety Cabinet	NuAire Safety Cabinets Class 2 Type A/B3 Transgenics and gene targeting safety cabinets (2 units)
Mouse Transgenic and Gene Targeting Facility	Centrifuge	Thermo IEC Centra CL3R Refrigerated Centrifuge Transgenics and gene targeting refrigerated centrifuge
Mouse Transgenic and Gene Targeting Facility	Electroporation System	Bio-Rad Gene Pulsar II Transgenics and gene targeting electroporation system
Mouse Transgenic and Gene Targeting Facility	Biospecimen Banking - Freezer	Custom BioGenic Systems Liquid Nitrogen (LN2) Freezer Transgenics and gene targeting liquid nitrogen freezer
Mouse Transgenic and Gene Targeting Facility	Biospecimen Banking - Freezer	Thermo Fisher Scientific -80 C Transgenics and gene targeting -80 C freezer
Mouse Transgenic and Gene Targeting Facility	Biospecimen Banking - Freezer	Frigidaire -20 C Freezer Transgenics and gene targeting freezer
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - ES Cell Gene Targeting System	Service Gene targeting services through transfection and microinjection of murine embryonic stem (ES) cells to produce germline knockout (KO) or knockin (KI) mice.
Mouse Transgenic and Gene Targeting Facility	Incubator	NuAire CO2 water jacketed Incubators Transgenics and gene targeting incubators (3 units)
Mouse Transgenic and Gene Targeting Facility	Spectrophotometer	ThermoFisher Scientific NanoDrop Lite Measures nucleic acid and protein concentration
Mouse Transgenic and Gene Targeting Facility	Cell Manipulator - Microinjection system	Eppendorf FemtoJet Microinjection System Transgenics and gene targeting pronuclear injection system
Mouse Transgenic and Gene Targeting Facility	Micromanipulator	Eppendorf Transferman NK 2 Micromanipulators Transgenics and gene targeting micromanipulators (2 units)
Mouse Transgenic and Gene Targeting Facility	Microscope	Nikon Eclipse TE200 Inverted Microscope Transgenics and gene targeting microinjection microscope
Mouse Transgenic and Gene Targeting Facility	Microscope	Nikon Eclipse TS100 (cell culture scope) Transgenics and gene targeting cell culture scope
Mouse Transgenic and Gene Targeting Facility	Microscope	Nikon SMZ1500 Zoom Stereomicroscopes Transgenics and gene targeting dissecting microscopes (2 units)
Mouse Transgenic and Gene Targeting Facility	Microscope	Nikon SMZ800 Zoom Stereomicroscopes Transgenics and gene targeting surgical microscope
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - CRISPR/Cas9 Design and Reagent Preparation	Service Service to provide consultation, design a CRISPR model, synthesize sgRNAs and prepare microinjection mix
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - CRISPR/Cas9 Donor Construction/Preparation	Service Service to construct a donor DNA for a CRISPR model.Knock-In (KI, >80bp), Knock-Out (KO), Conditional Knock-Out (cKO - two steps), Point Mutation (PM)
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Transgenesis by Random Integrations	Service Service to provide custom services related to microinjection, ES cell culture, mouse surgery, or mouse reproduction. The core facility will provide services and/or training related to our capabilities that are not specifically covered by our service list. These services are available for an hourly fee. Examples include: production of MEFs (murine embryonic fibroblasts), polar body biopsy, reproductive surgery, blastomere injection, frozen embryo shipment, training
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Mouse Line Recovery from Cryopreservation	Service Service to thaw and implant previously cryopreserved mouse embryos From frozen embryos or frozen sperm.
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Cryopreserved Mouse Embryo Storage	Service Service to store cryopreserved mouse embryos in liquid nitrogen (LN2)
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Derivation of Mouse Embryonic Stem (ES) cell lines	Service Service to produce embryonic stem (ES) cells from an existing mouse line key words: murine embryonic stem cells
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Chimeric Mouse Production	Service Service to produce chimeric mice for analysis through microinjection of murine embryonic stem (ES) cells into blastocyst stage embryos.
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Mouse Colony Expansion	Service Service to use superovulation and surgical implantation to produce large cohorts of age matched mice for experimentation or to quickly expand a mouse colony
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Mouse Embryo Cryopreservation	Service Service to cryopreserve valuable mouse lines for storage or shipment to other investigators. Heterozygous embryos or Homozygous embryos
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Mouse In vitro Fertilization (IVF)	Service Service to perform in vitro fertilization of mouse embryos using fresh or frozen sperm.
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Rederivation of Mouse Lines	Service Service to rederive mouse lines obtained from a source other than a Brown University approved vendor. Rederived mouse lines may be housed in any campus mouse facility.
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Embryo Microinjection/Electroporation	Service Service to perform pronuclear microinjection of 0.5 dpc mouse embryos to produce transgenic or CRISPR founders on an FVB/N or C57/BL6 background. Custom backgrounds also available.
Mouse Transgenic and Gene Targeting Facility	Electroporation System	ThermoFisher Scientific Neon Transfection System Nucleic acid and protein electroporation
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - CRISPR/Cas9 Genotyping	Service Service to genotype founders and G1 progeny from a CRISPR project
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - CRISPR/Cas9 Germline Transmission	Service Service to subclone and sequence a PCR amplicon from founders of a CRISPR project
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Germline Transmission	Service Service to breed chimera from mouse ES cell injection or founders from a CRISPR project with WT mice for germline transmission
Mouse Transgenic and Gene Targeting Facility	Transgenics and Gene Targeting - Sperm Cryopreservation	Service Service to cryopreserve sperm from males provided by investigators
Mouse Transgenic and Gene Targeting Facility	Biospecimen Banking - Freezer	SP Scientific, Bio-cool IV40A Embryo cryopreservation at a controlled slow rate
Mouse Transgenic and Gene Targeting Facility	Microinjection system	Prime Tech, Piezo Drive PMM4G Intracytoplasmic sperm injection
Nanofabrication Central Facility (NCF)	Deposition System - Thin Film Deposition	Angstrom - Multi-Target Sputtering System This system accommodates four 3-inch sputtering sources and a variety of PVD processes (RF and DC). The temperature of the substrate can be increased up to 800˚C.
Nanofabrication Central Facility (NCF)	Chemical Hood	Wet chemistry workbenches equipped with fume hoods for lithography The Microelectronics Facility has a number of wet chemistry workbenches equipped with fume hoods for chemical processing (cleaning, wet etching, electroplating, anodization, etc) employed in the fabrication of semiconductor and nanomaterials devices. These hoods also house spinners for applying photoresist for lithography and other polymers.
Nanofabrication Central Facility (NCF)	Lithography - Mask Aligner	Karl Suss MJB3 UV300 Mask Aligner for Lithography The Karl Suss MJB3 UV300 3-inch mask aligner is designed for high-resolution photolithography, with a 350 W mercury lamp and Suss diffraction-reducing exposure optics. The primary exposure wavelengths of 365 or 403 nm lead to roughly 1 µm minimum feature size. For smaller feature sizes, electron-beam lithography is available in the Electron Microscope Facility.
Nanofabrication Central Facility (NCF)	Lithography - Maskless Aligner	Heidleberg MLA 150 Maskless Aligner MLA150 Maskless Aligner is a high-speed, direct-write, optical lithography system to fabricate nano- and micro-patterned materials and surfaces at low-cost and over large areas. The instrument comprises two laser illumination modules, optical systems to steer the laser beams and control exposure, integrated cameras for high-accuracy alignment to pre-existing structures, automated translation stage, real-time pneumatic autofocus, and a class 10 climate controlled chamber to achieve photo-lithographically defined structures with feature size ≤1μm.
Nanofabrication Central Facility (NCF)	Lithography - Flexible Mylar-Mask	Newport-Oriel flexible Mylar-Mask Lithography System Newport-Oriel flexible Mylar-Mask Lithography System is designed for printing from flexible Mylar masks onto substrates as large as 4” x 4” square or 5” diameter. It is capable of printing 5-micron features with placement and alignment to approximately 2 microns with appropriate alignment marks.
Nanofabrication Central Facility (NCF)	Evaporator - Thin Film Deposition	Electron Beam Evaporator This system deposits thin films of inorganic materials, usually metals, from a four-pocket electron-beam source inside a high vacuum (cryopumped) chamber. Deposition rates of up to 0.1 micron/minute are possible for some materials. This system can easily accomodate relatively large, 3-D objects and has substrate heating to 300 C for flat substrates. Restrictions on what materials may be evaporated are somewhat less stringent than for our other evaporators.
Nanofabrication Central Facility (NCF)	Lithography - Imprinter	NIL Technology Nano Imprinter The Nano Imprinter system offers thermal and UV nanoimprint and imprinting in vacuum if needed. The system transfers the patterns, usually nanohole or nanopillar arrays, from a silicon stamp to a nanoimprint-polymer-coated substrate by applying heat and pressure.
Nanofabrication Central Facility (NCF)	Evaporator - Thin Film Deposition	Angstrom Organic Evaporator The Angstrom Resitive-heated Evaporator is a thermal evaporator coupled with a nitrogen glove box. It is for depositing thin organic and inorganic films when either the deposition material or the substrate is adversely affected by moisture or oxygen. Samples and/or evaporants are loaded from a nitrogen glove box maintained at under 10 ppm of oxygen and under 1 ppm of water vapor.
Nanofabrication Central Facility (NCF)	Deposition System - Thin Film Deposition	Cambridge NanoTech Atomic Layer Deposition System The Cambridge NanoTech Fiji F200 series Atomic Layer Deposition System is a modular medium to high-vacuum ALD system that accommodates a wide range of deposition modes. This tool is currently configured with precursors for metallic and oxide layers of Hafnium, Aluminum, and Tungsten.
Nanofabrication Central Facility (NCF)	Deposition System - Thin Film Deposition	Plasmatherm Model 790, Fluorine Chemistry Reactive Ion Etching Plasma Enhanced Chemical Vapor Deposition System (RIE PECVD) The PlasmaTherm Model 790 RIE-PECVD system has a computer-controlled single-wafer turbopumped chamber that provides reactive ion etching (RIE) and plasma-enhanced chemical vapor deposition (PECVD) capabilities. RIE is accomplished using fluorine-chemistry gases (CF4, CBrF3, CHF3, SF6, etc.) with up to 500 W RF power. PECVD capability provides low-temperature (up to 350 C) SiO2 and Si3N4 deposition from silane chemistry.
Nanofabrication Central Facility (NCF)	Profilometer - Characterization	DekTak3 Profilometer The DekTak3 is a computer-controlled surface profile measuring system, which accurately measures step heights from below 50 A to over 50 µm by moving a diamond-tipped stylus over the surface. Equipped with video camera and surface profile analysis software.
Nanofabrication Central Facility (NCF)	Analytical Prober	Karl Suss 200mm Precision Manual Analytical Prober 200mm Precision Manual Analytical Prober. The PM8 provides the stability and resolution required for precise probe positioning. Manual submicron semiconductor failure analysis and in-process testing probe station. Submicron precision and stability with a fine-glide chuck stage and 8 in. x 8 in. X-Y movement. As fast as a motorized stage but with the simplicity and resolution of a manual system. Vacuum Chuck: 8 in. dia. Mitutoyo high magnification microscope with two long working distance objectives. Microscope lifts for easier access to the probes and device under test. The station is fitted with six Wentworth micromanipulators having tungsten needle probes with 3 micron tips.
Nanofabrication Central Facility (NCF)	Deposition System - Thin Film Deposition	Lesker Lab 18 thin film deposition system The Lab-18 thin film deposition system is a combined electron-beam evaporator and RF sputtering Physical Vapor Deposition (PVD) system that makes high quality, research-grade metallic, semiconducting, and dielectric thin films. The Lab 18 includes a four-pocket electron beam evaporator as well as two 2” magnetron sputter sources. Two mass flow regulated gas lines provide for control of chamber pressure and gas composition for reactive sputtering.
Nanofabrication Central Facility (NCF)	Plasma Etching System	Inductively Coupled Plasma RIE System The SPTS LPX is an inductively-coupled plasma (ICP) reactive-ion etcher (RIE). It can etch high-aspect ratio structures in a wide range of materials, including silicon, silicon dioxide, and silicon nitride. This system is configured with a range of gases for reactive- and physical-ion etching, including SF6, C4F8, CF4, O2, and Ar. The LPX-ICP system is equipped with a single-wafer load-lock transfer arm for 100mm wafers; smaller wafers and small pieces may be processed on the system using a carrier wafer.
Nanofabrication Central Facility (NCF)	Characterization - Thin Film Deposition	JA Woollam, M-2000 Ellipsometer Variable Angle Research Grade The JA Woollam, M-2000 Variable Angle Research Grade ellipsometer measures angle- and wavelength-dependent reflectivity and transmissivity data over a wide spectral range (from ultraviolet to near-infrared) that is analyzed to directly to determine optical properties of single- and multi-layer films (e.g., their thickness and complex wavelength-dependent refractive index), which provide insight into their underlying chemical, electronic, and mechanical properties.
Nanofabrication Central Facility (NCF)	Furnace	Wet and Dry Oxididation Quartz tube furnace for thermal oxide growth on silicon by a chemical reaction between the silicon and either dry oxygen or water vapor at atmospheric pressure. The typical temperature range for the oxidation of silicon for wafer fabrication 750˚C to 1100˚C. The tubes accommodate multiple 2 inch wafers.
NanoTools Facility	X-Ray Diffraction System, 2 Dimensional	Bruker, D8, XPS This Bruker D8 Discover X-ray Diffraction System can be configured with a point and line source x-rays. A Vantec 500 2D area detector or a LinxEye (0D, 1D)detector can be used for the analysis. The system is suitable for texture, stress, and micro-x-ray diffraction as well as for orientation and epitaxy studies. The instrument has in-situ capabilities for studies at low/high temperature and under vacuum to study properties as a function of time, temperature, gas environment or vacuum. A capillary spinner stage is also available for investigations of air sensible materials with the sample prepared in a capillary glass.
NanoTools Facility	X-Ray Diffration System, High-Resolution	Bruker, D8, XPS This Bruker D8 Discover X-ray Diffraction System includes a line source configuration system with a LinxEye (0D, 1D) detector and a Scintillator detector. The system is suitable to determine thickness, crystallographic structure and strain in epitaxially thin films as well as high resolution analysis of bulk materials. X-ray reflectometry (XRR), high resolution XRD, grazing incidence diffraction (GI-XRD), in-plane GID (IGID) and reciprocal space mapping (RSM) are some techniques that can be performed with this configuration. High resolution is obtained using parallel beam optics: Goebel mirror, monochromators, soller slits and analyzer crystals.
NanoTools Facility	Microscope - Atomic Force	Asylum, MFP-3D, AFM The Asylum MFP-3D Origin atomic force microscope (AFM) is a multi-mode instrument. It is equipped with a closed loop operation in all three axes with high precision, resolution and low noise operation. The closed loop Z scanner eliminates hysteresis. The AFM provides a 90 µm X and Y range (< 0.5nm noise) and 15 µm Z range (Z sensor, 0.25 nm noise) and detector noise <15 pm. It also includes Inverted optical lever design that eliminates interference artifacts and a low-coherence infrared (860 nm) super-luminescent diode (SLD) light source (class 1M). Applications include dual AC resonance tracking (DART), electric force microscopy (EFM), force mapping mode, lateral force microscopy (LFM), magnetic force microscopy (MFM), kelvin probe force microscopy (KPFM), piezo-response force microscopy (PFM), and conductive AFM (C-AFM) with ORCA.
NanoTools Facility	Microscope - Confocal Raman	Witec, Alpha 300 M+, CRM The Witec Alpha 300 Confocal Raman Microscope is equipt with different scan modes for local Raman spectra, mapping distribution of phases within a sample and with 3D image generation and depth profile of samples. The depth profiling and 3D imaging capabilities of the Alpha 300 provide the ability to analyze the interior of transparent samples without microtome sectioning or freeze etching. Multi-wavelength coupler for selection of 532 nm or 633 nm wavelength laser sources and a Ray Shield coupler for measurements of Raman spectra at low wave numbers. Fast Raman imaging with integration time in the milliseconds order per spectrum. A heating stage for in-situ measurements in the temperature range 25°C to 1400°C with a thermal stability of ± 0.3°C.
NanoTools Facility	Spectrometer - Electron Paramagnetic Resonance (EPR)	Bruker, EMX+, EPR The Bruker EMX Electron Paramagnetic Resonance (EPR) Spectrometer is equipt for the Technique for the direct detection of paramagnetic species. The EMX EPR has a digital resolution of 24 bit center field, a field sweep up to 256,000 points, high-sensitivity resonator with irradiation window, dual channel, simultaneous detection of 1st and 2nd harmonic, and sensitivity S/N up to 2000:1. The system has a helium temperature control system for low temperature measurements in the temperature range 3.8 K (~-269 °C) to 300 K (~27°C). Applications span a wide range of areas an include kinetics of radical reactions, oxidation and reduction process, polymerization reactions, degradation of compounds by light, organometallic compounds and catalysis, free radicals, and antioxidants and radical scavengers.
NMR Facility	Nuclear Magnetic Resonance (NMR) Spectrometer	Bruker 600 Avance III HD Ascend z-BBFO probe for all nuclei (most sensitive for all nuclei)
NMR Facility	Nuclear Magnetic Resonance (NMR) Spectrometer	Bruker 400 Avance III Ultra-Shield z-BBFO probe (2nd most sensitive for 1H and broadband nuclei) - (HR-MAS probe)
NMR Facility	Nuclear Magnetic Resonance (NMR) Spectrometer	Bruker 400 Avance Ultra-Shield z-BBO (3rd best sensitivity for broadband nuclei)
Organic Synthesis Core (Legorreta Cancer Center at Brown University)	Training and Technical Assistance	Service Assist investigators with experimental plans for drug synthesis for lead optimization. Facilitate organic synthesis efforts through interactions with the Department of Chemistry, Industry or other collaborations. Provide support for grant submissions.
Organoids Core (Legorreta Cancer Center at Brown University)	Training and Technical Assistance	Service Advise and assist investigators with the production of organoids to facilitate cancer biology, drug efficacy and toxicity evaluation of therapeutics towards tumor versus normal organoids that express different cancer gene mutants. Provide support for the growth and maintenance of organoid and spheroid cultures including passaging. Maintain a collection of established organoids that can be provided to investigators for research. Develop gene knockout and overexpression matched patient-derived organoids. Assist investigators with planning of drug screens working with the drug discovery capability. Provide support for grant submissions.
PC - Albertus Magnus Hall Labs	Environmental Chamber Contact: Maia Bailey	Percival Scientific 1 unit
PC - Albertus Magnus Hall Labs	Environmental Chamber Contact: Maia Bailey	Percival Scientific, AR-22L Growth Chamber For Arabidopsis
PC - Albertus Magnus Hall Labs	Imaging System - Camera Contact: Pat Ewanchuk	Fastec HiSpec1, Low-Light High-Speed Camera Innovative Low-Light High-Speed Camera. Monochrome with 2GB Memory, C-Mount, includes ImageBLITZ Auto Trigger, Burst Trigger Mode, Multi- Sequence Record Mode (1280 x 1024 at 506fps) 2 Units
PC - Albertus Magnus Hall Labs	Microscope - Electron Contact: Joe DeGiorgis	Philips EM-300 Transmission Electron Microscope (TEM) Transmission electron microscopy
PC - Albertus Magnus Hall Labs	Sample Preparation - Laboratory - Prep Lab Contact: Joe DeGiorgis	Electron Microscopy Prep Lab Laboratory space for preparing samples for electron microscopy
PC - Albertus Magnus Hall Labs	Microscope - Electron Contact: Joe DeGiorgis	Amray-1000 Scanning Electron Microscope (SEM) Scanning Electron Microscope equipped with EDEX for elemental analysis and a digital imaging system, a Zeiss Axiophot equipped for bright field, dark field, DIC and fluorescence microscopy with a digital imaging system
PC - Albertus Magnus Hall Labs	Microtome Contact: Joe DeGiorgis	Porter-Blum MT-2B Ultramicrotome Porter-Blum MT-2B UltraMicrotomes, 2 Units
PC - Albertus Magnus Hall Labs	Aquatic System Contact: Pat Ewanchuk	Aquatic Habitats Glass Tank System and Life Support Controller Glass tank system and life support controller with low water level protection (18-10 gallon tanks)
PC - Albertus Magnus Hall Labs	Imaging System - Visualization- Camera lucida Contact: James Waters	Leica Drawing tube Drawing tube, for MZ and M-series, the object and the drawing surface are visible at the same time, suitable for drawing for left and right handed persons, work is possible in the daylight. Documents and scales can be mirrored-in and photographed along with the object.
PC - Albertus Magnus Hall Labs	Analyzer - Respiratory physiology Contact: James Waters	LI-COR Biosciences - Li-7000 CO2/H2O The LI-7000 is a high performance, dual cell, differential gas analyzer. It uses a dichroic beam splitter and two separate detectors to measure infrared absorption by CO2 and H2O in the same gas stream. The LI-7000 is ideally suited for applications that demand high speed, high precision measurements in absolute and/or differential modes, including plant and insect gas exchange using chamber-based methods, atmospheric-surface flux eddy covariance and Bowen ratio techniques, vertical profiling, and general atmospheric monitoring.
PC - Hickey Hall Labs	DNA Sequencer Contact: Elisabeth Arevalo	ABI Prism 3100 Genetic Analyzer Used for DNA sequencing and fragment analysis. The ABI PRISM 3100 Genetic Analyzer is an automated capillary electrophoresis system that can separate, detect, and analyze up to 16 capillaries of fluorescently labeled DNA fragments in one run.
PC - Hickey Hall Labs	PCR Thermal Cycler Contact: Charles Toth	Stratagene Mx3000p Real-time PCR Thermal Cycler This instrument is available for gene expression analysis, microarray data validation, SNP genotyping, pathogen detection, DNA methylation analysis, and chromatin immuno-precipitation studies. Agilent's qPCR software, MxPro, provides users with an intuitive interface, quick experiment design, powerful data analysis and easy report generation.
PC - Hickey Hall Labs	Fluorescence Activated Cell Sorter (FACS) Contact: Charles Toth	Flow Cytometer- Accuri C6 The BD Accuri C6 is a personal flow cytometer that is easy to use, simple to maintain, and affordable.
PC - Hickey Hall Labs	Cold Room Contact: Charles Toth	Walk-In Cold Room
PC - Hickey Hall Labs	Analyzer - Cell Metabolism Contact: Marla Tipping	Seahorse Biosciencies, XFe Extracellular Flux Analyzers, XFe96 Platform for metabolic assays that simultaneously measures the two major energy producing pathways of the cell - mitochondrial respiration and glycolysis - in a microplate, in real-time.
PC - Hickey Hall Labs	Laboratory - Tissue Culture Contact: Charles Toth	Tissue Culture Laboratory Space and instrumentation for tissue culture preparation
PC - Hickey Hall Labs	Imaging System - Gel Imager Contact: Yinsheng Wan	LI-COR Odyssey IR (Infrared) Imaging System Instrumentation for quantitating western blots.
PC - Hickey Hall Labs	Fluorescence Activated Cell Sorter (FACS) Contact: Nicanor Austriaco	Cellometer Vision Image Cytometry The Vision CBA System combines the simplicity of image cytometry with the power of flow analysis software to offer user-friendly cell-based assays
PC - Hickey Hall Labs	Spectrophotometer Contact: Charles Toth	Thermo Scientific NanoDrop UV/VIS
PC - Sowa Hall Labs	Microscope Contact: Joe DeGiorgis	Zeiss LMS 700 Flexible Confocal Microscope Performs fluorescence measurements, creates optical sections of samples and combines them into 3D image stacks.
Pharmaceutical Development Institute	current Good Manufacturing Practice (cGMP) Facility	Service Rapid expansion in the markets for biologics and small molecule pharmaceutical products has created a critical demand for skilled professionals (from equipment operators to advanced technical and quality assurance personnel) and additional infrastructure to support drug development and manufacturing. The current Good Manufacturing Practice (cGMP) Facility at the University of Rhode Island (URI) offers a state-of-the-art training, development and manufacturing facility for GMP production of solid oral dosage forms.
Pharmaceutical Development Institute	GMP manufacturing	Clinical Research Service, GMP manufacturing Assisting academic, government and industry partners with the manufacture of solid dose forms for veterinary and human use
Pharmaceutical Development Institute	GMP analytical testing	Clinical Research Service, GMP analytical Providing pharmaceutical testing services including turn-key stability studies
Pharmaceutical Development Institute	Training Center	Clinical Research Service, GMP education Providing GMP industrial experience in drug manufacturing and analytical testing for students in various related undergraduate, graduate and adult education programs, as well as industry-specific training in collaboration with pharmaceutical and biotechnology firms.
Plant Environmental Center	Greenhouse Contact: Nicholas Vasques	Plant environmental center with seven separate, computer controlled rooms where conditions like lighting, temperature, and humidity can be fine tuned; an additional 17 controlled plant growth environments provided by growth chambers (15) and walk-in growth rooms (2) A plant environmental center with a suite of supporting facilities, including a classroom, a headhouse for potting and other prep work, and growth chambers for plants.
Program for Environmental influences on Child Health Outcomes (ECHO) (Lifespan - Hasbro Children's Hospital)	Program for Environmental influences on Child Health Outcomes (ECHO)	Clinical Research Resources, Environmental Influences on Child Health The ECHO program investigates how exposure to a range of environmental factors in early development — from conception through early childhood — influences the health of children and adolescents.
Proteomics Core - Rhode Island Hospital	High Performance Liquid Chromatography (HPLC)	Agilent 1290 Infinity II Modular UHPLC system with automated multisampler and quaternary pump for analyte separations up to 600 bar.
Proteomics Core - Rhode Island Hospital	Bioinformatics Analysis - MASCOT	Software: Matrix Science MASCOT Search Engine Software for MS data analysis through statistical evaluation of matches between observed and projected peptide fragments.
Proteomics Core - Rhode Island Hospital	Bioinformatics Analysis - ProteoIQ	Software: NuSep ProteoIQ Mass Spec Data Analysis Software for post-analysis of MASCOT results. Protein and peptide probabilities generated and protein relative quantitation is performed by spectral counting. Normalized and with standard deviations.
Proteomics Core - Rhode Island Hospital	Imaging System - Gel Imager	Bio-Rad Molecular Imager VersaDoc Quantitative digital imaging system for single or multi-color images. Includes multiplexed samples (1-D or 2-D gels), chemiluminescent and chemifluorescent blots, and microplates.
Proteomics Core - Rhode Island Hospital	High Performance Liquid Chromatography (HPLC)	Thermo Scientific nLC 1200 High-performance LC for nanoflow resolution of complex analyte mixtures at up to 1200 bar.
Proteomics Core - Rhode Island Hospital	Liquid Chromatography - Mass Spectrometer (LC - MS)	Thermo Scientific Q Exactive Plus Mass Spectrometer LC-MS/MS system combines high-performance quadrupole with high resolution, accurate-mass (HR/AM) Orbitrap for total proteome characterization. Max resolving power= 140,000; max scan speed= 12Hz, Intra-scan dynamic range > 5000:, Quadrupole mass filter.
Proteomics Core - Rhode Island Hospital	Spectrophotometer	Thermo Scientific NanoDrop 2000 Measures DNA, RNA, and protein concentrations, and purity (A260/A280 ratio). Conc. range= 2 ng/microliter-15,000 ng/microliter; Min Sample size = 0.5 microliter.
Proteomics Core - Rhode Island Hospital	Technical Assistance - Mass Spectrometry	Service Service to provide Imaging Mass Spectrometry Data Analysis.
Proteomics Core - Rhode Island Hospital	Technical Assistance - Protein Determination	Service Service to provide Protein Determination (BCA assay).
Proteomics Core - Rhode Island Hospital	Technical Assistance - Protein Extraction	Service Service to provide ReadyPrep Protein Extraction Kit (Total Protein and Sequential Extraction).
Proteomics Core - Rhode Island Hospital	Technical Assistance - Protein In-Gel Digestion	Service Service to provide In-gel digestion LC/MS analysis and protein database search.
Proteomics Core - Rhode Island Hospital	Technical Assistance - Protein In-Solution Digestion	Service Service to provide In-solution digestion LC/MS analysis and protein database search.
Proteomics Core - Rhode Island Hospital	Technical Assistance - Protein Quantification	Service Service to provide Data interpretation and protein quantification.
Proteomics Core - Rhode Island Hospital	Technical Assistance - Protein Sample Clean-up	Service Service to provide ReadyPrep 2D Cleanup Kit.
Proteomics Core - Rhode Island Hospital	Mass Spectrometer	Thermo Scientific TSQ Quantiva Triple-quadrupole MS for identification and absolute quantification of biomarkers, target proteins/peptides with known post-translational modifications in selected mass ranges.
Proteomics Core - Rhode Island Hospital	Microplate Reader	GloMax Discover - Multimode Detection System Multi-mode detection instrument offering flexible use of filters and includes: high-performance, luminescence, fluorescence, UV-Visible absorbance, BRET and FRET, two-color filtered luminescence and kinetic measurement capabilities
Proteomics Core - Rhode Island Hospital	Cell Counter	Thermo Scientific Countess II Automated Cell Counter Automated image analysis of cell suspensions providing rapid measurement of total cell counts, viability and average cell size.
Proteomics Facility - Brown	Analyzer - Calorimeter	Microcal Isothermal Titration 200 (ITC) Characterization of molecular interactions of small molecules, proteins, antibodies, nucleic acids, lipids and other biomolecules.
Proteomics Facility - Brown	Analyzer - Calorimeter	Microcal VP Differential Scanning (DSC) Measurement of heat changes that occur in biomolecules during controlled increase or decrease in temperature.
Proteomics Facility - Brown	Fluorometer - Spectrofluorometer	Horiba Jobin Yvon FluoroMax-4 Fluorescence detection. A heated cell allows temperature studies.
Proteomics Facility - Brown	Spectrometer	JASCO J-815 Circular Dichroism (CD) Spectrometer Protein folding studies, Protein conformational studies, DNA/RNA interactions, Enzyme kinetics, Purity testing of optically active substances, quantitative analysis of pharmaceuticals, natural products chemistry, biochemistry and macromolecules, rapid scanning (time resolved) experiments. Peltier device for temperature studies.
Proteomics Facility - Brown	Spectrophotometer	Thermo Scientific NanoDrop 8000 A full spectral microvolume (microliter) UV-Vis analysis spectrophotometer for measuring DNA, RNA, and protein of 8 samples simultaneously.
Proteomics Facility - Brown	Technical Assistance	Service Service to provide Proteomics Technal Assistance
Proteomics Facility - Brown	Mass Spectrometer	Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer is a bench-top ESI LC-MS/MS system that combines quadrupole precursor ion selection with high-resolution, accurate-mass (HRAM) Orbitrap detection.
Research Integrity and Compliance-Multi-institutions	Export Controls - Brown Contact: Jules Blyth Brown Export Control Compliance Webpage	Research Compliance, Export Controls Export Controls regulate the shipment or transfer, by whatever means, of controlled items, software, technology, or services out of the U.S. and also restricts the release of certain information to foreign nationals here in the U.S.
Research Integrity and Compliance-Multi-institutions	Biosafety - Lifespan - Rhode Island Hospital and The Miriam Hospital Contact: Jacqueline Poore	Research Compliance, Biosafety The Biohazards and Laboratory Safety Committee reviews and approves the use of potentially hazardous agents in the laboratory setting.
Research Integrity and Compliance-Multi-institutions	IRB - Care New England - Kent Hospital Contact: Donna Coppola	Human Subjects Protection
Research Integrity and Compliance-Multi-institutions	IRB - Care New England - Women and Infants Hospital Contact: Amber Latronica Women & Infants Institutional Review Board Webpage	Human Subjects Protection Women & Infants Institutional Review Board (IRB) is a committee established to review and approve research involving human subjects. The purpose of the IRB is to protect the rights and welfare of human research subjects and to ensure that all human subject research be conducted in accordance with federal, state, institutional, and ethical guidelines.
Research Integrity and Compliance-Multi-institutions	IRB - Lifespan - Rhode Island Hospital and The Miriam Hospital Contact: Candy Frater	Human Subjects Protection The Institutional Review Board (IRB) is a committee made up of physicians, scientists and community members who ensure that research involving human research subjects is well planned and ethical. All research that involves human subjects or their identifiable data must be reviewed by the IRB.
Research Integrity and Compliance-Multi-institutions	IRB - Care New England - Butler Hospital Contact: Cheryl Cordeiro	Human Subjects Protection
Research Integrity and Compliance-Multi-institutions	IRB - Brown Contact: Sheila Vandal HRPP/IRB Home Page	Human Subjects Protection The IRB is a diverse body of Brown faculty researchers, physicians, staff and unaffiliated community members appointed by Brown’s Vice President for Research and charged with reviewing human subject research protocols to uphold two broad standards To ensure that participants are not placed at undue risk; and To ensure that participants give informed consent to their participation free of coercion or undue influence To this end, projects that meet the regulatory definition of human subject research must be reviewed and approved by the IRB prior to initiation.
Research Integrity and Compliance-Multi-institutions	IRB - VA Providence Healthcare System Contact: Val Micucci	Human Subjects Protection
Research Integrity and Compliance-Multi-institutions	IRB - University of Rhode Island Contact: Mary Riedford Human Subjects Protection - URI Webpage	Human Subjects Protection The University of Rhode Island Institutional Review Board (IRB) reviews research projects which involve human subjects to ensure that two broad standards are upheld: first, that subjects are not placed at undue risk; second, that they give uncoerced, informed consent to their participation.
Research Integrity and Compliance-Multi-institutions	IACUC - Brown University Contact: IACUC@brown.edu Brown IACUC Webpage	Animal Subjects Protection The ARPP is the administrative office dedicated to facilitating the submission, review and approval of IACUC protocols, supporting the various functions of the IACUC, and providing individual assistance to researchers whenever needed.
Research Integrity and Compliance-Multi-institutions	IACUC - Lifespan - Rhode Island Hospital Contact: Jacqueline Poore	Animal Subjects Protection The Animal Welfare Committee (IACUC) is a committee made up of scientists and community members who ensure that research involving animal subjects is well planned and ethical.
Research Integrity and Compliance-Multi-institutions	IACUC - Care New England - Women and Infants Contact: Jacqueline Poore	Animal Subjects Protection
Research Integrity and Compliance-Multi-institutions	IACUC - VA Providence Healthcare System Contact: Tiffany Galligan Providence VA Medical Center IACUC Webpage	Animal Subjects Protection
Research Integrity and Compliance-Multi-institutions	IACUC - University of Rhode Island Contact: Gwen Currier IACUC - URI Webpage	Animal Subjects Protection The URI Institutional Animal Care and Use Committee (IACUC) is responsible for overseeing the provisions for the care and well -being of animals used for research and educational purposes at the University and serves the public by ensuring compliance with all legal and ethical standards regarding the use of vertebrate animals in research and teaching at URI.
Research Integrity and Compliance-Multi-institutions	Biosafety - Brown Contact: Devorah Weiner Institutional Biosafety Committee (IBC) Webpage	Research Compliance, Biosafety The Institutional Biosafety Committee (IBC) evaluates and provides oversight of the use of biohazardous agents to ensure compliance with appropriate regulations and guidelines and to safeguard the health and safety of Brown University personnel, the community, and the environment.
Research Integrity and Compliance-Multi-institutions	Biosafety - University of Rhode Island Contact: Gwen Currier URI Biosafety Committee Webpage	Research Compliance, Biosafety The Institutional Biosafety Committee (IBC) reviews and approves Biological Research protocols.
Research Integrity and Compliance-Multi-institutions	Export Controls - University of Rhode Island Contact: Carol Connolly URI Export Controls Webpage	Research Compliance, Export Controls The Export Controls office ensures that all personnel, including employees, visiting scientists, postdoctoral fellows, students, and other persons retained by or working at or for URI conduct their affairs in accordance with U.S. laws and regulations, including compliance with U.S. export control laws and regulations applicable to its operations.
Rhode Island Consortium for Nanoscience and Nanotechnology	Sample Preparation - Sputter Coater System Contact: Irene Andreu	Cressington 7002-8 sputter coater with film thickness monitor Coat non-conducting samples with gold for use on the SEM, rotating/tilting stage for coating of large specimens.
Rhode Island Consortium for Nanoscience and Nanotechnology	X-Ray Diffraction System Contact: Irene Andreu	Rigaku Ultima IV multipurpose X-ray diffraction (XRD) system micro-crystalline diffraction, thin-film diffraction, small angle scattering, and in-plane scattering.
Rhode Island Consortium for Nanoscience and Nanotechnology	Microscope - Transmission Electron Microscope Contact: Irene Andreu TEM	JEOL JEM-2100 LaB6 Transmission Electron Microscope (TEM) Transmission electron microscope JEOL JEM 2100 with sub nanometer resolution, cryoTEM (Gatan) and energy dispersive X-ray spectroscopy (Oxford Instruments)
Rhode Island Consortium for Nanoscience and Nanotechnology	Microscope - Field Emission-Scanning Electron Microscope (FE-SEM) Contact: Irene Andreu SIGMA VP FE-SEM	Zeiss Gemini Sigma VP Field Emission-Scanning Electron Microscope (FE-SEM) Field emission scanning electron microscope Zeiss Gemini Sigma VP, with cryoSEM (Gatan), energy dispersive X-ray spectroscopy (Oxford Instruments), variable pressure mode, backscattering detector, in lens detector and secondary electron detector
Rhode Island Consortium for Nanoscience and Nanotechnology	Microscope - High Content Screening System	Perkin Elmer - Opera Phenix High Content Screening System: Automated confocal fluorescence microscope designed for high-throughput 3D imaging of fluorescent samples in microplates, live-cell imaging, drug screening, spheroid imaging
Rhode Island Consortium for Nanoscience and Nanotechnology	Sample preparation - Plunge freezer Contact: Irene Andreu Vitrobot Mark IV	FEI Vitrobot Mark 2 Plunge Freezer for cryoTEM Automatic plunge freezer for cryoTEM sample preparation
Rhode Island Consortium for Nanoscience and Nanotechnology	Microtome Contact: Irene Andreu	Sorvall MT2-B ultramicrotome Preparation of biological tissue, cross sections and embedded samples for TEM.
Rhode Island Consortium for Nanoscience and Nanotechnology	Microscope - Confocal Raman Spectroscopy Contact: Irene Andreu	WITec alpha 300R Confocal imaging and chemical analysis by Raman spectroscopy up to 100x magnification, 3D chemical imaging, large area imaging, principal component analysis of chemical composition, upright and inverted mode, automated XY stage, 785 and 532 nm excitation lasers
Rhode Island Consortium for Nanoscience and Nanotechnology	Microscope - Fourier Transform Infrared Spectroscopy	Shimadzu AIM-9000 with Shimadzu IRTracer100 FTIR microscope and spectrometer, ATR, liquid and gas cell.
Rhode Island Consortium for Nanoscience and Nanotechnology	Sample Preparation - Critical Point Drier	Tousimis Sandri-PVT-3B Critical point dryer (CPD) Maintain structural integrity for soft tissue use of the SEM.
Rhode Island Consortium for Nanoscience and Nanotechnology	Sample Preparation - Automated pipettor	Opentrons OT-2 Automated sample preparation platform for staining well plates
Rhode Island Consortium for Nanoscience and Nanotechnology	Microscope - X-ray Contact: Irene Andreu	Zeiss Xradia Versa 610 with in situ tensile, compression and temperature stage X-ray microscopy and tomography of samples up to 10 cm in diameter with resolution up to 500 nm
Rhode Island Consortium for Nanoscience and Nanotechnology	Spectrometer - Energy Dispersive X-Ray Fluorescence Contact: Irene Andreu	Shimadzu EDX-8100 Energy dispersive X-ray fluorescence of powders, solids and liquids. Ambient pressure, vacuum and He atmosphere
Rhode Island Consortium for Nanoscience and Nanotechnology	Microscope - Scanning Transmission Electron Contact: Irene Andreu	JEOL F200 Scanning transmission electron microscope with cryogenic capabilities, direct electron camera (Gatan K3), Energy dispersive X-ray spectroscopy (JEOL), electron energy loss spectroscopy (Gatan). Sub nanometer resolution, 80 and 200 kV operation, TEM, STEM and diffraction
Rhode Island Consortium for Nanoscience and Nanotechnology	Microscope - Atomic Force Contact: Irene Andreu	Shimadzu SPM-9700 Scanning probe microscope for atomic force microscopy, magnetic force microscopy, liquid cell analysis, Kelvin force microscopy, I/V curves, nanomechanical measurements
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Nuclear Magnetic Resonance (NMR) Spectrometer	Bruker Avance III 300 with BBO probe Optimized for small molecule NMR
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Analyzer - Protein Quality	Tycho NT.6 The Tycho NT.6 verifies protein quality by looking at the structural integrity (or foldedness) of a protein. Changes in the intrinsic fluorescence of the sample are measured as a thermal ramp is applied. Changes in the fluorescence signal indicate transitions in the folding state of the protein. The Tycho can be used to study the stability of protein samples in different buffers or at different pH values. The measurement is completed in three minutes and uses a capillary tube to hold the sample.
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Characterization - Surface Plasmon Resonance	Biacore T200 SPR The Biacore T200 is a surface plasmon resonance instrument which can be used to characterize molecular interactions between biomolecules ranging in size from ions to viruses. The Biacore software provides a range of tools for kinetic analyses. These analyses can be performed using a multicycle approach (many samples against one ligand or when different ligands are immobilized), or alternatively, using fast, single cycle kinetics.
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Analyzer - Live Cell	Roche xCELLigence Real-Time Cell Analysis System Label free live cell analyzer
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Biological Safety Cabinet	NuAire, Laminar Flow Hood Cell culture facility
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Cell Counter	Nexcellom Cellometer Vision Cell Counter Automated cell counter
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Centrifuge	Beckman Avante High Speed Centrifuge High speed centrifuge
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Centrifuge	Thermo MultiFuge Centrifuge table-top Centrifuge
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Centrifuge - Ultra	Beckman Coulter Optima Beckman Optima L-100 XP ultracentrifuge Ultra centrifuge
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Centrifuge - Ultra	Sorvall Micro Ultra Centrifuge Ultra centrifuge
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Fluorescence Activated Cell Sorter (FACS)	Becton Dickinson (BD) Biosciences FACS Verse Flow cytometer Fluorescence-activated cell sorting
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Electrophoresis System - Gel Electrophoresis	Bio-Rad 2D Gel System Two Dimensional (2D) Gel Electrophoresis
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Liquid Chromatography	GE AKTA Fast Protein Liquid Chromatograph (FPLC) FPLC
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Chromatography	Teledyne-ISCO CombiFlash System Flash Chromatography
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Imaging System - Gel Imager	LI-COR Odyssey IR (Infrared) Imaging System IR gel imager
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Liquid Chromatography - Mass Spectrometer (LC - MS)	AB SCIEX TripleTOF 4600 and Shimadzu Prominence UFLC sytem ESI-TOF MS
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Mass Spectrometer	Shimadzu Axima MALDI-TOF MS/MS MALDI MS
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Mass Spectrometer	Thermo iCAPQ-a ICP-MS Elemental Analyzer
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Microplate Reader	Molecular Devices SpectraMax M2 Fluorescence/UV/VIS
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Microplate Reader - Luminometer	Promega GlowMax System Chemiluminescence
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Microscope	Nikon Eclipse E600 Upright Microscope Microscope
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Microscope	Nikon Eclipse Ti2 inverted confocal microscope Confocal Microscope
Rhode Island INBRE Centralized Research Core Facility (CRCF)	PCR Thermal Cycler	Applied Biosystems/Life Technologies ABI Vii7- qPCR Real Time-PCR
Rhode Island INBRE Centralized Research Core Facility (CRCF)	PCR Thermal Cycler	Eppendorf Mastercycler PCR PCR
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Spectropolarimeter	Jasco J-1100 Circular Dichroism (CD) Spectropolarimeter CD
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Spectrometer	Thermo Nicolet 380 Fourier Transformed Infrared Spectrometer (FT-IR) FT-IR
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Chromatography	Metrohm Ion Chromatography 940 Vario Ion Chromatography
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Spectrophotometer	Thermo Scientific NanoDrop UV/VIS
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Water Purification System - Deionized (DI)	Millipore Milli-Q Water System DI Water System
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Western Blotting System	Bio-Rad Turbo Trans Blot system Western Blotting
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Synthesizer, DNA/RNA	MerMade-4 Oligonucleotide synthesizer DNA/RNA Synthesizer
Rhode Island INBRE Centralized Research Core Facility (CRCF)	High Performance Liquid Chromatography (HPLC)	Shimadzu Nexera-i HPLC system High Performance Liquid Chromatography
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Microscope	EVOS FL Auto Cell Imaging System Cell-based imaging applications—including live-cell imaging, image tiling, and Z-stacking
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Spectrometer	Jasco Digital Polarimeter P2000 Polarimeter
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Imager - Biomolecular	Azure Sapphire Biomolecular Imager The Azure Sapphire Biomolecular Imager is a laser scanning system has four lasers (488, 520, 658 and 784 nm) giving a wide range of excitation. The instrument supports long and short wavelength Near IR fluorescence, red/green/blue imaging, and chemiluminescent imaging. Multiple detectors are used depending on the excitation wavelength and application for maximum sensitivity. It can accommodate gels up to 25cm by 25 cm.
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Incubator	Heraeus Heracell Double Stacked Incubator The Heraeus Heracell Double Stacked Incubator has Copper Chambers, which protects samples while optimizing cell growth with fast recovery characteristics.
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Nuclear Magnetic Resonance (NMR) Spectrometer	Varian 500 MHz NMR spectrometer Optimized for small molecule NMR
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Mass Spectrometer	ABSciex Qtrap 4500 Triple Quadrapole LC/MS Has Shimadzu HPLC system attached
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Microplate Reader	Molecular Devices ID3 Microplate Reader Uv/vis, Chemilumenesence, fluorescence
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Spectrophotometer	Genesys 50 UV/VIS UV/Vis
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Imager and Microplate Reader	BioTek Cytation 5 Imager fluorescence imaging
Rhode Island INBRE Centralized Research Core Facility (CRCF)	Analyzer - Metabolism Analysis	Agilent Seahorse XFe96 Analyzer 96 well plate metabolism analysis
Rhode Island INBRE Molecular Informatics Core (MIC)	Bioinformatics Analysis Contact: Christopher Hemme Bioinformatics and Data Science at the MIC	Service - Bioinformatics We provide bioinformatics consultation and services to the Rhode Island INBRE community and to the general scientific community of Rhode Island. In addition to traditional bioinformatic services, our Core is expanding to 3D/VR/AR visualization services in conjunction with the URI 3D Visualization Laboratory. We are currently developing 3D/VR visualization apps for a variety of platforms including smartphones, Vive/SteamVR, and others. We also have access to the 3D printer at the URI 3D Visualization Core for printing of marcomolecules at a reasonable price.
Rhode Island INBRE Molecular Informatics Core (MIC)	Bioanalyzer Contact: Janet Atoyan	Agilent Bioanalyzer 2100 Provides fast and automated separation, sizing and quantification of DNA, RNA and proteins by miniaturized Lab-on-a-Chip electrophoresis
Rhode Island INBRE Molecular Informatics Core (MIC)	Disrupter Contact: Janet Atoyan	Covaris S220 High Performance Ultrasonicator Automated acoustic disruption and homogenization of cells and tissue samples using focused ultrasonic energy at 500 KHz. Performs DNA Shearing
Rhode Island INBRE Molecular Informatics Core (MIC)	DNA Sequencer Contact: Janet Atoyan	Illumina MiSeq DNA NextGen Sequencing Performs clonal amplification, genomic DNA sequencing, and data analysis with base calling, alignment, variant calling, and reporting.
Rhode Island INBRE Molecular Informatics Core (MIC)	DNA Sequencer Contact: Janet Atoyan	Applied Biosystems 3500xl Genetic Analyzer DNA Sanger Sequencing & Fragment Analysis: Fluorescence-based instruments utilizing capillary electrophoresis for DNA sequencing and fragment analysis.
Rhode Island INBRE Molecular Informatics Core (MIC)	Fluorometer Contact: Janet Atoyan	Invitrogen Qubit Fluorometer that uses fluorescent dyes bound to specific molecules to quantify DNA, RNA and proteins
Rhode Island INBRE Molecular Informatics Core (MIC)	Sample Preparation - Library Preparation System Contact: Janet Atoyan	IntegenX Apollo 324 System NextGen Sequencing (NGS) Library Preparation System Automated liquid handling instrument dedicated to the preparation of sample libraries for Next Generation Sequencing
Rhode Island INBRE Molecular Informatics Core (MIC)	PCR Thermal Cycler Contact: Janet Atoyan	Roche LC480 qPCR Systems Quantitative PCR (qPCR) instrument. Used for highly accurate qualitative and quantitative detection of nucleic acids and gene expression.
Rhode Island Nuclear Science Center	Reactor, Research and Test Contact: Cameron Goodwin	2 Mega-Watt, light water cooled, pool type reactor Neutron and gamma irradiation and experimental set-up, as well as analysis
RIC - Fogarty Life Sciences Labs	Sample Preparation - Knifemaker Contact: Breea Govenar	LKB 7800 Knifemaker Slide/Sample Preparation
RIC - Fogarty Life Sciences Labs	Microtome Contact: Breea Govenar	Leica RM2165 Motorized Rotary Microtome Slide/Sample Preparation
RIC - Fogarty Life Sciences Labs	Microtome Contact: Breea Govenar	TBS Microtome plus Cryostat Slide/Sample Preparation
RIC - Fogarty Life Sciences Labs	Microscope Contact: Breea Govenar	American Optical Series 10 Fluorescence Microstart Microscopy course
RIC - Fogarty Life Sciences Labs	Microscope Contact: Breea Govenar	Nikon E600 Epifluorescence with DIC/Phase and digital camera Research
RIC - Fogarty Life Sciences Labs	Microscope Contact: Breea Govenar	Olympus CKS41 Inverted Microscope Tissue culture general use
RIC - Fogarty Life Sciences Labs	Microscope Contact: Breea Govenar	Olympus Compound Light Microscope General use
RIC - Fogarty Life Sciences Labs	Microscope Contact: Breea Govenar	Olympus FluoView 1000 Laser Scanning Confocal Microscope Research and Microscopy course
RIC - Fogarty Life Sciences Labs	Microscope Contact: Breea Govenar	Olympus Inverted Epifluorescence Microscope with digital camera Tissue culture/Research
RIC - Fogarty Life Sciences Labs	Microscope Contact: Breea Govenar	Zeiss SteREO discovery V8 Microscope with Digital Camera Research
RIC - Fogarty Life Sciences Labs	Aquatic System - Wet Lab / Aquarium room Contact: Breea Govenar	Aquaria and related equipment Research
RIC - Fogarty Life Sciences Labs	Autoclave Contact: Breea Govenar	Autoclave Microbiology/Research
RIC - Fogarty Life Sciences Labs	Biological Safety Cabinet Contact: Breea Govenar	Labconco class II Biological Safety Cabinet Used for tissue culture
RIC - Fogarty Life Sciences Labs	Biological Safety Cabinet Contact: Breea Govenar	Sterile laminar flow hood Microbiology prep
RIC - Fogarty Life Sciences Labs	Centrifuge Contact: Breea Govenar	Eppendorf 5810R Refrigerated Centrifuge Used for tissue culture
RIC - Fogarty Life Sciences Labs	Centrifuge Contact: Breea Govenar	Sorvall Discovery M120SE Mini Ultracentrifuge Research/Cell fractionation
RIC - Fogarty Life Sciences Labs	Centrifuge Contact: Breea Govenar	Sorvall Superspeed RC2 Centrifuge General use
RIC - Fogarty Life Sciences Labs	Centrifuge Contact: Breea Govenar	Sorvall Superspeed RC5 Plus Centrifuge Research
RIC - Fogarty Life Sciences Labs	Centrifuge Contact: Breea Govenar	Thermo IEC Centra CL3R Refrigerated Centrifuge Genetics and Cell & Molec courses
RIC - Fogarty Life Sciences Labs	Cold Room Contact: Breea Govenar	Walk-In Cold Room Large cold room for experimentation and storage
RIC - Fogarty Life Sciences Labs	Dishwasher Contact: Breea Govenar	Dishwasher Microbiology/Research
RIC - Fogarty Life Sciences Labs	Disrupter Contact: Breea Govenar	French Pressure Cell Press Research
RIC - Fogarty Life Sciences Labs	Disrupter Contact: Breea Govenar	Polytron Tissue Grinder Slide/Sample Preparation
RIC - Fogarty Life Sciences Labs	Disrupter Contact: Breea Govenar	Sonicator General use and research
RIC - Fogarty Life Sciences Labs	Disrupter Contact: Breea Govenar	Sonicator with cup Research and graduate courses
RIC - Fogarty Life Sciences Labs	Electroporation System Contact: Breea Govenar	Bio-Rad Micropulser Electroporator Research
RIC - Fogarty Life Sciences Labs	Sample Preparation - Freeze Dry System Contact: Breea Govenar	ATMO VAC 5009 freeze dryer Slide/Sample Preparation
RIC - Fogarty Life Sciences Labs	Biospecimen Banking - Freezer Contact: Breea Govenar	Thermolyne Liquid Nitrogen cryogenic storage system Cell storage
RIC - Fogarty Life Sciences Labs	Biospecimen Banking - Freezer Contact: Breea Govenar	Ultralow Freezer Used for freezing biological samples, 6 units
RIC - Fogarty Life Sciences Labs	Imaging System - Gel Imager Contact: Breea Govenar	InGenius Syngene Gel Documentation System Research
RIC - Fogarty Life Sciences Labs	Ice Machine Contact: Breea Govenar	Ice Machine General use
RIC - Fogarty Life Sciences Labs	Imaging System - Dark Room Contact: Breea Govenar	Imaging System - Dark Room Gel imaging and analysis
RIC - Fogarty Life Sciences Labs	Incubator Contact: Breea Govenar	Non CO2 Incubator Used for tissue culture
RIC - Fogarty Life Sciences Labs	Incubator Contact: Breea Govenar	Thermo CO2 Incubators Used for tissue culture, 2 units
RIC - Fogarty Life Sciences Labs	Incubator Contact: Breea Govenar	Refrigerated Incubator Used for tissue culture
RIC - Fogarty Life Sciences Labs	Laboratory - Tissue Culture Contact: Breea Govenar	Tissue Culture Room A room outfitted with tissue culture instrumentation
RIC - Fogarty Life Sciences Labs	Microplate Reader Contact: Breea Govenar	Lenovo Automated Plate Reader Research
RIC - Fogarty Life Sciences Labs	Microplate Reader Contact: Breea Govenar	Thermo Labsystems Multiskan MMCC/340 plate reader Research
RIC - Fogarty Life Sciences Labs	Sample Preparation - Oven Contact: Breea Govenar	Drying Oven General use
RIC - Fogarty Life Sciences Labs	PCR Thermal Cycler Contact: Breea Govenar	Bio-Rad IQS Real time PCR thermocycler Research
RIC - Fogarty Life Sciences Labs	PCR Thermal Cycler Contact: Breea Govenar	Eppendorf Gradient Mastercycler PCR instrumentation, 2 units
RIC - Fogarty Life Sciences Labs	Incubator - Shaker Contact: Breea Govenar	Incubator/Shakers Multiple units
RIC - Fogarty Life Sciences Labs	Spectrophotometer Contact: Breea Govenar	BioRad SmartSpec Plus Research
RIC - Fogarty Life Sciences Labs	Spectrophotometer Contact: Breea Govenar	Eppendorf Biophotometer Gectrophotometerseral use
RIC - Fogarty Life Sciences Labs	Spectrophotometer Contact: Breea Govenar	Spectronic 21 D UV/VIS Research
RIC - Fogarty Life Sciences Labs	Spectrophotometer Contact: Breea Govenar	Therm Spectronic Genesys UV/VIS Scanning Research, 6 units
RIC - Fogarty Life Sciences Labs	Spectrophotometer Contact: Breea Govenar	Thermo Scientific NanoDrop ND-1000 UV/VIS, 2 units
RIC - Fogarty Life Sciences Labs	Water Purification System Contact: Breea Govenar	Barnstead Still Water Purifier General use for teaching labs
RIC - Fogarty Life Sciences Labs	Water Purification System Contact: Breea Govenar	Millipore DirectQ (X2) Tissue culture
RIC - Fogarty Life Sciences Labs	Water Purification System Contact: Breea Govenar	Millipore NanoPure Diamond 2nd floor research use
RIC - Fogarty Life Sciences Labs	Imaging System - X-ray Film Contact: Breea Govenar	X-ray film processor Blot imaging
RISD Media Resources	Imaging System - Audio\|Visual	Kodak zi 10 Video Camera (8 units) Portable HD pocket camcorder, batteries, adaptor cables, cases, accessories
RISD Media Resources	Imaging System - Audio\|Visual	H4N ZOOM Audio Recorder (5 Units) High performance portable digital audio recorder, batteries, adaptor cables, cases, accessories
RISD Media Resources	Imaging System - Audio\|Visual	ZOOM Q3 Video Camera (7 Units) Portable palm camcorder, batteries, adaptor cables, cases, accessories
RISD Media Resources	Imaging System - Audio\|Visual	EPS-SonyPMWEX1R-01 (2 Units) High performance HD CMOS solid state video camera, batteries, portable hard drive, adaptor cables, cases, studio lighting equipment, accessories
RISD Nature Lab	Aquatic System	Marine Ecological Habitats Closed-System Aquarium 560 L closed-system recirculating marine holding tanks with temperature control (2 units)
RISD Nature Lab	Microscope	Phenom G2Pro Scanning Electron Microscope (SEM) Desktop Scanning Electron Microscope with ProSuite tiling and remote access software
RISD Nature Lab	Microscope	Olympus SZX16 Stereomicroscope Light microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software
RISD Nature Lab	Microscope	Olympus IX51 Inverted Fluorescent/Brightfield Microscope Fluorescence/brightfield microscope with 12.5 MP Jenoptik progressive scan camera, computer workstation, graphics and imaging software
RISD Nature Lab	Microscope	Olympus CH30 Upright Light Microscope Upright light microscope with 5 MP Jenoptik digital camera, Canon Vixia HFS20 HD video camera, computer workstation, graphics and imaging software (2 units)
RISD Nature Lab	Microscope	Olympus SZ40 Stereomicroscope Light microscope with 5 MP Jenoptik digital camera, computer workstation, graphics and imaging software
RISD Nature Lab	Microscope	Olympus SZ30 Stereomicroscope Light microscope with LED illuminator (24 units)
RISD Nature Lab	GPS Unit	Trimble Geo 7x Subfoot GPS Survey-grade high resolution handheld GPS unit with sub-foot accuracy
RISD Nature Lab	GPS Unit	Garmin eTrex 30 (10 units) Mapping grade gps unit for student use
RISD Nature Lab	Imaging System - Videocamera - High Speed	Edgertronic - monochrome High speed videocamera for capturing slow motion footage. Capable of Resolutions up to 1280x1024, frame rates at lower resolution up to nearly 18,000 fps
RISD Nature Lab	Imaging System - Videocamera - High Speed	Edgertronic - color High speed videocamera for capturing slow motion footage. Capable of Resolutions up to 1280x1024, frame rates at lower resolution up to nearly 18,000 fps
RISD Nature Lab	Imaging System - Videocamera - High Speed	Phantom Miro M120 Digital high speed video camera, resolution up to 1920x1080 at 800fps
RISD Nature Lab	Imaging System - 3D Scanner	Artec Spider High resolution 3D scanner designed specifically for CAD users
RISD Nature Lab	Imaging System - 3D Scanner	Structure Sensor Scanners (3) for use with iPad Air, capable of 3D scanning objects and entire rooms
RISD Nature Lab	Workstation, Computer Geographic Information System (GIS)	EPC workstations (3) Computer workstations outfitted with ArcGIS, auto cad and the full adobe creative suite
Roger Williams Medical Center Resources	Flow Cytometry CoreFlow Cytometry Core Webpage	Flow Cytometry and Cell Sorting The Flow Cytometry Core facility is dedicated to advancing research projects requiring cell sorting and/or analysis of cell populations by flow cytometry. The core offers training on and access to shared use instrumentation for analytical flow cytometry, services for fluorescence activated cell sorting (FACS) as well as technical consultation and support on experimental design, execution, and data analysis.
Roger Williams Medical Center Resources	Imaging CoreImaging Core Webpage	Zeiss LSM 700 confocal, Zeiss Axioplan 2 optical, Zeiss Axiovert 200M optical, IVIS Model 100 The Imaging Core facility provides technical and logistical access for fixed and live cell fluorescence imaging via visual and digital fluorescent microscopes. This core also offers the ability to visualize fluorescent and bioluminescent markers in live animals via an IVIS imager.
Roger Williams Medical Center Resources	Molecular CoreMolecular Core Webpage	Applied Biosystem PRISM 7000 Sequence Detection System, Bio-Rad ChemiDoc Molecular Imager, Bio-Rad CFX96 Touch Real-Time PCR Detection System The molecular core offers the capability of performing PCR analysis, quantitative real-time PCR analysis, and digital gel documentation.
Roger Williams Medical Center Resources	Cell Immunotherapy and Gene Therapy (CITGT) Good Manufacturing Practice (GMP) Facility Contact: Steven C. Katz, MD, FACS (GMP) Facility Webpage	Services and Equipment The Cell Immunotherapy and Gene Therapy GMP facility supports the manufacture of investigational new drug (IND) products for principal investigators under FDA rules and regulations.
Roger Williams Medical Center Resources	Tissue Bank CoreTissue Bank Core Webpage	Biospecimen Banking - Tissue Banking and Specimen access The Tissue Repository Core (TRC) is designed to facilitate translational cancer research by procuring and storing diseased and normal control tissues, with the associated clinical data, for RWMC investigators and outside clients.
Roger Williams Medical Center Resources	Animal Services CoreAnimal Services Core Webpage	Husbandry, Surgical Procedures and Injections The Animal Care Facility is fully maintained, certified, and is supervised by a certified veterinarian, and our Office of Research Administration.
RWU Lab Spaces	Fluorescence Activated Cell Sorter (FACS) Contact: Marcie Marston	Millipore Guava easyCyte Flow Cytometer Cell sorting and analysis
RWU Lab Spaces	Gas Chromatograph - Mass Spectrometer (GC - MS) Contact: Nancy Breen	Agilent 5890 Gas Chromatograph - Mass Spectrometer (GC - MS) wth Mass Selective Detetor (MSD) GC MS for teaching and research
RWU Lab Spaces	High Performance Liquid Chromatography (HPLC) Contact: Nancy Breen	Waters 2695 High Performance Liquid Chromatograph-MS / ZQ Micromass Mass Spectrometer LC - MS for teaching and research
RWU Lab Spaces	Gas Chromatograph Contact: Nancy Breen	Agilent 7890 Gas Chromatography with DB-23 column GC for fatty acid analysis
Salve Regina Biology and Biomedical Sciences	Fluorescence Activated Cell Sorter (FACS)	Millipore Guava EasyCyte 8 Flow Cytometer Single blue (488 nm), dual blue and red (642 nm), or triple blue, red, and violet (405 nm) excitation lasers provide up to 12 simultaneous detection parameters, including 10 fluorescent colors plus forward and side scatter for size and granularity determination. The guava easyCyte family also meets your sample throughput needs by offering both single sample and multi-sample processing.
Scientific Illustration and Visual Design	Design - Illustration, Graphic Design, and Data Displays	Service BioMedical Communications offers medical and scientific illustration, graphic design, and data displays for use in web, digital, and print media to faculty across the Division of Biology and Medicine.
Sexually Transmitted Disease Clinic	Research - Infectious Diseases Clinical Research	The Miriam Hospital clinical trials unit offers the newest treatments for HIV and hepatitis C (HCV) infections. The experienced research staff consists of physicians, nurses, a data manager, a regulatory assistant and laboratory personnel. We conduct trials offered through the AIDS Clinical Trials Group (ACTG) network, funded by the National Institutes of Health, in association with the Partners/Harvard AIDS Clinical Trials Unit. The priority of ACTG studies is to evaluate new strategies for treating HIV infection and preventing HIV complications, and to evaluate new treatments for hepatitis C.
Single Cell Technologies Core (Legorreta Cancer Center at Brown University)	Training and Technical Assistance	Service Advise investigators with experimental design for single cell analysis including implementation of technical plans as well as analysis of results. Advise on single cell genomics, RNA-seq, ChIP-seq and bioinformatic analysis. Provide support for grant submissions.
Structural Biology Facility	Nuclear Magnetic Resonance (NMR) Spectrometer	Bruker 500 Avance II An NMR spectrometer optimized for studying proteins in solution. This spectrometer is most useful for tracking binding interactions, measuring dynamic properties of proteins, and assigning protein resonances. Capable of using 5 mm and 3 mm tubes. Also suitable for proton NMR of small molecules and natural products.
Structural Biology Facility	Nuclear Magnetic Resonance (NMR) Spectrometer	Bruker 850 MHz Avance III HD, with TCI cryoprobe An NMR spectrometer optimized for studying proteins in solution. This spectrometer is ideal for determining protein structures and measuring protein dynamics. Its extreme sensitivity allows studies on otherwise intractable samples. Capable of using 5 mm, 3 mm, and shaped NMR tubes. Also suitable for proton NMR of small molecules and natural products
Structural Biology Facility	X-Ray Diffraction System	Rigaku ACTOR robot and Saturn 944 HG CCD An instrument useful for obtaining X-ray diffraction patterns of proteins and other biomacromolecules under cryogenic or room-temperature conditions. Rapid screening and sorting of up to 80 candidate crystals is possible.
Structural Biology Facility	Nuclear Magnetic Resonance (NMR) Spectrometer	Bruker AVANCE III HD 600 MHz High Performance Digital NMR Spectrometer Bruker NEO 600 MHz NMR spectrometer for high resolution solution-state protein NMR experiments 4 RF channels, triple-resonance (1H-13C-15N) inverse cryoprobe with cooled 1H, 13C and 15N preamplifiers.
Translational Oncology Core (Legorreta Cancer Center at Brown University)	Training and Technical Assistance	Service Advise investigators on study design leading to translational clinical protocols. For prioritized studies, provide assistance with clinical protocol preparation as well as NIH, Industry or Foundation grant submissions to secure funding for the research.
URI Sources, Transport, Exposure & Effects of PFAS (STEEP)	Mass Spectrometer Contact: Simon Vojta Mass Spectrometer Available to Researchers	SCIEX X500R QTOF PLATFORM coupled to an EXION LC AC SYSTEM A tandem (MS/MS) mass spectrometer combining a quadrupole and a time-of-flight analyzer allows collecting high-resolution MS and MRM spectra. The instrument is suitable for both quantitative analysis as well as non-targeted approach and operates under SCIEX OS software. The collected data are evaluated using an independent processing station (SCIEX Alpha Workstation 2020) equipped with SCIEX OS-Q software
X-ray Reconstruction of Moving Morphology Facility (XROMM)	Imaging System - Computed Tomography (CT) Scanner	Animage Fidex Veterinary Veterinary CT Scanner designed for animals in the size range from rats to dogs. In vivo scanning of anesthetized animals is possible.
X-ray Reconstruction of Moving Morphology Facility (XROMM)	Imaging System - Videoradiography RoomXROMM	Imaging Systems and Services Custom designed biplanar videoradiography system for XROMM studies of human and animal subjects.
X-ray Reconstruction of Moving Morphology Facility (XROMM)	Imaging system X-Ray FluoroscopesXROMM	Radiological Imaging Mobile C-Arm X-ray Two retrofitted with 30-cm image intensifiers and high-speed video cameras for measuring accurate 3D skeletal kinematics of small to medium-sized animals.
X-ray Reconstruction of Moving Morphology Facility (XROMM)	Imaging System - MicroComputed Tomography (uCT) Scanner	Bruker BioSpin SkyScan 1276 in vivo microCT scanner for small animals (mouse to rat size)

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